Pandoraea captiosa

General Information

Pandoraea captiosa is a fascinating microorganism belonging to the genus Pandoraea. This genus is known for its diverse metabolic capabilities and environmental adaptability. One of the most intriguing aspects of P. captiosa is its potential role in bioremediation. The species has shown the ability to degrade various environmental pollutants, making it a valuable candidate for cleaning up contaminated sites. Additionally, P. captiosa has been isolated from clinical settings, indicating its relevance in medical microbiology. Its presence in such environments suggests that it may have unique interactions with human hosts, which could be important for understanding opportunistic infections, especially in immunocompromised individuals. From a research perspective, the genetic makeup of P. captiosa is of significant interest. The organism's genome reveals a wealth of genes involved in antibiotic resistance and metabolic versatility. This genetic information can provide insights into how bacteria adapt to different environments and develop resistance to antimicrobial agents. In summary, Pandoraea captiosa stands out due to its bioremediation potential, clinical relevance, and genetic adaptability, making it a valuable subject for ongoing scientific research and environmental applications.

Pandoraea captiosa is a fascinating bacterium that belongs to the genus Pandoraea, which is known for its unique ecological niches and potential biotechnological applications. This organism was first isolated from a patient with cystic fibrosis, highlighting its association with human health, particularly in immunocompromised individuals. What makes P. captiosa particularly interesting is its ability to thrive in diverse environments, including soil and water, which suggests a remarkable adaptability. One of the most notable characteristics of P. captiosa is its metabolic versatility. It has been shown to utilize a variety of carbon sources, which makes it a candidate for bioremediation efforts, especially in the degradation of complex organic compounds. This metabolic flexibility not only contributes to its survival in various habitats but also positions it as a valuable organism for environmental biotechnology. Additionally, Pandoraea species, including P. captiosa, have been studied for their potential in producing bioactive compounds. These compounds may have pharmaceutical applications, making this organism a subject of interest in drug discovery and development. The ability to produce unique secondary metabolites could lead to the identification of novel antibiotics or other therapeutic agents, which is crucial in the face of rising antibiotic resistance. Furthermore, research into P. captiosa contributes to our understanding of microbial diversity and the role of environmental bacteria in human health. Its presence in clinical settings raises questions about its pathogenic potential and interactions with the human microbiome, making it a significant organism for further study in both clinical and environmental microbiology. Overall, Pandoraea captiosa exemplifies the intersection of environmental science and medical research, underscoring the importance of studying diverse microbial life.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Betaproteobacteria

Order: Burkholderiales

Family: Burkholderiaceae

Genus: Pandoraea

Species: Pandoraea captiosa

NCBI ID

2508302

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/902/459/775/GCA_902459775.1_LMG_31118

File for sequence-based predictions:
GCA_902459775.1_LMG_31118_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Pandoraea captiosa is a Gram-negative bacterium that has been increasingly recognized in clinical settings, particularly in patients with cystic fibrosis (CF). It is known to be part of the complex microbial community found in the lungs of CF patients, where it can contribute to chronic lung infections and inflammation. The presence of Pandoraea captiosa in respiratory samples has been associated with disease exacerbations and may complicate the management of CF due to its potential for antimicrobial resistance. Pathogenicity: Pandoraea captiosa exhibits pathogenic characteristics, including the ability to form biofilms, which enhances its survival in hostile environments such as the lungs of CF patients. This biofilm formation is a significant factor in its virulence, making it difficult to eradicate with standard antibiotic therapies. Antimicrobial Resistance: There are documented cases of multidrug resistance in Pandoraea captiosa, which poses a challenge for treatment. The organism has shown resistance to several classes of antibiotics, including beta-lactams and aminoglycosides, complicating therapeutic options for infected patients. Immune Evasion Strategies: Pandoraea captiosa may employ various strategies to evade the host immune response, including the production of virulence factors that inhibit phagocytosis and modulate inflammatory responses. This ability to evade the immune system can lead to persistent infections, particularly in immunocompromised individuals. Medical Applications: While Pandoraea captiosa is primarily associated with negative clinical outcomes, understanding its role in the microbiome of CF patients may lead to potential therapeutic strategies, such as the development of targeted probiotics or bacteriophage therapies aimed at restoring a healthy microbial balance in the lungs. In summary, Pandoraea captiosa is clinically significant due to its association with chronic infections in CF patients, its potential for antimicrobial resistance, and its role in complicating the management of respiratory diseases. Further research is needed to fully elucidate its pathogenic mechanisms and potential therapeutic avenues.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Pandoraea captiosa is a bacterium that is primarily associated with soil environments and aquatic habitats. This microorganism is often found in freshwater ecosystems, where it plays a significant role in the degradation of organic matter. Its ability to thrive in nutrient-rich environments makes it an important player in the cycling of nutrients within these biomes. In soil ecosystems, Pandoraea captiosa contributes to the breakdown of complex organic compounds, facilitating nutrient availability for plants and other organisms. This process is crucial for maintaining soil health and fertility. The bacterium exhibits symbiotic relationships with various plant species, enhancing their growth by improving nutrient uptake. Additionally, Pandoraea captiosa has been isolated from clinical environments, particularly in association with human infections, which highlights its adaptability to different ecological niches. In these contexts, it may interact with other microorganisms, influencing microbial community dynamics and potentially impacting human health. Overall, Pandoraea captiosa demonstrates a remarkable ability to adapt to diverse biomes, contributing to both ecological balance and human health through its various interactions within these environments.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Pandoraea captiosa has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where Pandoraea captiosa is utilized for its unique metabolic capabilities. This organism is known for its ability to degrade complex organic compounds, making it valuable in biodegradation processes, particularly in the treatment of contaminated environments. Its enzymatic activity allows it to break down pollutants, contributing to effective waste management strategies. In the realm of biofuel production, Pandoraea captiosa can be involved in fermentation processes that convert biomass into biofuels. The organism's metabolic pathways can be harnessed to optimize the conversion of organic materials into ethanol or other biofuels, thus supporting sustainable energy initiatives. Additionally, Pandoraea captiosa has potential applications in pharmaceutical development. Its ability to produce various secondary metabolites can be explored for the development of new drugs or therapeutic agents. The organism's unique biochemical properties may lead to the discovery of novel compounds with medicinal value. Overall, Pandoraea captiosa represents a versatile microorganism with promising applications across multiple industries, particularly in waste management, biofuel production, and pharmaceutical development, through its involvement in fermentation, biodegradation, and enzyme production processes.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-pro-1.5	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openchat/openchat-7b	mistralai/mistral-7b-instruct	google/gemini-pro	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat
Motility	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	aerobic ✓	N/A	N/A	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	true	true	true	false	true	true	false	false	true	true	true	false	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	false	false	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Host association	N/A	true	true	true	false	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	gamma	beta	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

Back to Search