Brucella lupini

General Information

Brucella lupini is a fascinating microorganism that belongs to the genus Brucella, which is well-known for its pathogenic species affecting various animals and humans. However, B. lupini stands out due to its unique ecological niche and potential applications in agriculture and biotechnology. One of the most intriguing aspects of B. lupini is its association with lupin plants. This bacterium has been isolated from the root nodules of lupins, where it plays a role in nitrogen fixation. This symbiotic relationship is particularly valuable because it helps improve soil fertility and reduces the need for chemical fertilizers, making B. lupini an important player in sustainable agriculture. Another noteworthy characteristic of B. lupini is its genetic makeup. The genome of this bacterium has been sequenced, revealing insights into its metabolic pathways and potential for biotechnological applications. For instance, the presence of genes involved in the synthesis of bioactive compounds suggests that B. lupini could be harnessed for the production of natural products with pharmaceutical or agricultural significance. Moreover, B. lupini exhibits a high degree of adaptability to different environmental conditions, which makes it a robust candidate for various biotechnological processes. Its ability to thrive in diverse habitats, coupled with its symbiotic capabilities, underscores its potential as a biofertilizer and a biocontrol agent. In summary, Brucella lupini is a microorganism of significant interest due to its symbiotic relationship with lupin plants, its genetic potential for producing valuable bioactive compounds, and its adaptability to various environments. These characteristics make it a promising candidate for applications in sustainable agriculture and biotechnology.

Brucella lupini is a notable member of the genus Brucella, which is known for its role in zoonotic infections. This particular species was first identified in 2006 and is primarily associated with lupins, a type of leguminous plant. One of the most interesting aspects of B. lupini is its ability to form symbiotic relationships with certain plants, particularly in the context of nitrogen fixation. This characteristic makes it valuable for agricultural research, especially in sustainable farming practices where enhancing soil fertility is crucial. Unique Metabolic Capabilities: B. lupini exhibits unique metabolic pathways that allow it to thrive in specific environmental conditions. Its ability to utilize various carbon sources can be of significant interest in biotechnological applications, particularly in the development of biofertilizers. Research Implications: The study of B. lupini can provide insights into the mechanisms of plant-microbe interactions, which are essential for understanding how to improve crop yields and resilience against environmental stressors. Furthermore, its potential role in the nitrogen cycle highlights its importance in ecosystem functioning and sustainability. Potential for Biocontrol: There is ongoing research into the potential of B. lupini as a biocontrol agent against certain plant pathogens, which could lead to more environmentally friendly agricultural practices. This aspect of B. lupini could pave the way for innovative strategies in integrated pest management. In summary, Brucella lupini stands out not only for its unique ecological interactions but also for its potential applications in agriculture and environmental sustainability, making it a valuable subject for further research.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Alphaproteobacteria

Order: Hyphomicrobiales

Family: Brucellaceae

Genus: Brucella

Species: Brucella lupini

NCBI ID

255457

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/252/535/GCF_002252535.1_ASM225253v1

File for sequence-based predictions:
GCF_002252535.1_ASM225253v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Brucella lupini is a lesser-known member of the genus Brucella, which is primarily associated with zoonotic infections in humans and animals. While Brucella lupini has been primarily identified in canines, its clinical implications are still being explored. It is important to note that the genus Brucella is known for causing brucellosis, a significant infectious disease that can lead to chronic infections in humans, characterized by symptoms such as fever, sweats, malaise, and muscle pain. Although Brucella lupini has not been as extensively studied as other species like Brucella abortus or Brucella melitensis, its potential to cause infections in humans cannot be entirely ruled out, especially in immunocompromised individuals or those with close contact with infected animals. The pathogenicity of Brucella species is attributed to their ability to evade the immune response through various mechanisms, including the inhibition of phagosome-lysosome fusion and the modulation of host cell signaling pathways. In terms of antimicrobial resistance, there is limited data on Brucella lupini, but the genus is generally known for its susceptibility to certain antibiotics, such as doxycycline and rifampin, which are commonly used in the treatment of brucellosis. However, the emergence of resistance in other Brucella species raises concerns about the effectiveness of treatment options. Currently, there are no known medical applications of Brucella lupini in terms of probiotics, vaccines, or therapeutics. However, understanding its role in canine health and its potential zoonotic implications is crucial for public health. Continued research is necessary to fully elucidate the clinical relevance of Brucella lupini and its impact on human health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Brucella lupini is a species of bacteria that is primarily associated with the agricultural and livestock environments. This microorganism is known to inhabit the gastrointestinal tracts of various animals, particularly in ruminants such as cattle and sheep. Its presence in these environments is significant due to its role in causing brucellosis, a disease that can affect both animals and humans, highlighting its impact on animal health and public health. Ecological Niches: In its natural habitat, _Brucella lupini thrives in the microbiomes of the digestive systems of its hosts. It is adapted to survive in the anaerobic conditions of the gut, where it can utilize nutrients from the host's diet. This adaptation allows it to establish a niche that is crucial for its survival and reproduction. Interactions with Surroundings: The bacterium plays a notable role in the ecosystem by influencing the health of livestock populations. Infected animals can experience reproductive issues, which can lead to economic losses in farming. Furthermore, Brucella lupini can be transmitted to humans through unpasteurized dairy products or direct contact with infected animals, making it a significant concern for zoonotic transmission. Overall, Brucella lupini is a microorganism that exemplifies the complex interactions within agricultural biomes, where it not only affects the health of its hosts but also has broader implications for human health and agricultural practices.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Brucella lupini has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its role in biodegradation, where it can break down complex organic compounds, making it valuable in the treatment of contaminated environments. Its ability to degrade pollutants can be harnessed in waste treatment facilities, helping to reduce the environmental impact of industrial waste. In the realm of biotechnology, Brucella lupini is being explored for its potential in fermentation processes. This microorganism can be utilized to produce specific metabolites that may have applications in food production or as bioactive compounds in pharmaceuticals. The fermentation capabilities of Brucella lupini could lead to the development of novel bioproducts that are both sustainable and efficient. Moreover, the enzymatic activity of Brucella lupini is of interest for pharmaceutical development. The enzymes produced by this microorganism can be studied for their potential use in drug formulation or as biocatalysts in various chemical reactions. This could open new avenues for the synthesis of complex molecules in the pharmaceutical industry. Overall, Brucella lupini presents a promising opportunity for innovation in biofuel production, where its metabolic pathways could be engineered to enhance the yield of biofuels from organic waste materials. The integration of this microorganism into existing industrial processes could lead to more sustainable practices and the development of new technologies.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-4o	openai/gpt-4o	google/gemini-flash-1.5	google/gemini-flash-1.5	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openchat/openchat-7b	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	TRUE	false ✗	true ✓	true ✓	false ✗	true ✓	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain variable ✗	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain positive ✗	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	aerobic ✓	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	coccus ✗	coccus ✗	bacillus ✓	coccus ✗	bacillus ✓	coccus ✗	bacillus ✓	coccus ✗	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗

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