Nocardia aurantia

General Information

Nocardia aurantia is a fascinating microorganism belonging to the genus Nocardia, which is known for its complex life cycle and diverse metabolic capabilities. One of the most intriguing aspects of Nocardia aurantia is its ability to degrade a wide range of organic compounds, making it a valuable organism in the field of bioremediation. This species can break down pollutants such as hydrocarbons, which are common environmental contaminants, thus playing a crucial role in cleaning up oil spills and other hazardous waste sites. Another unique feature of Nocardia aurantia is its production of secondary metabolites, including antibiotics and enzymes. These compounds have significant pharmaceutical and industrial applications. For instance, the antibiotics produced by Nocardia aurantia can be used to combat various bacterial infections, while its enzymes are utilized in processes such as the synthesis of fine chemicals and the degradation of complex polymers. From a research perspective, Nocardia aurantia is also valuable due to its complex cell wall structure, which contains mycolic acids. This characteristic is shared with other members of the Nocardia genus and is of particular interest because it contributes to the organism's resistance to desiccation and chemical damage. Studying these cell wall components can provide insights into developing new antimicrobial strategies and understanding the mechanisms of pathogenicity in related species. In summary, Nocardia aurantia is a microorganism of significant interest due to its bioremediation potential, production of valuable secondary metabolites, and unique cell wall structure. These attributes make it a subject of ongoing research in environmental science, pharmaceuticals, and microbiology.

Nocardia aurantia is a fascinating actinobacterium known for its unique ecological niche and metabolic capabilities. This microorganism is primarily found in soil and decaying organic matter, contributing significantly to the degradation of complex organic compounds. Its ability to break down various hydrocarbons makes it an important player in bioremediation processes, particularly in environments contaminated with petroleum products. This characteristic not only highlights its ecological importance but also positions it as a valuable organism for environmental biotechnology. One of the most interesting aspects of Nocardia aurantia is its production of secondary metabolites, which can have antimicrobial properties. This has drawn attention from researchers looking to discover new antibiotics or other bioactive compounds that could be used in medicine. The potential for discovering novel therapeutic agents from this organism underscores its significance in pharmaceutical research. Additionally, Nocardia aurantia exhibits a unique filamentous growth form, which is characteristic of many members of the genus Nocardia. This morphology not only aids in its survival in harsh environments but also plays a role in its interactions with other microorganisms in the soil ecosystem. Understanding these interactions can provide insights into microbial ecology and the dynamics of soil health. Overall, Nocardia aurantia stands out due to its ecological role, potential for biotechnological applications, and its contributions to our understanding of microbial diversity and interactions in natural environments.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Nocardiaceae

Genus: Nocardia

Species: Nocardia aurantia

NCBI ID

2585199

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/009/604/425/GCF_009604425.1_ASM960442v1

File for sequence-based predictions:
GCF_009604425.1_ASM960442v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Nocardia aurantia is a member of the genus Nocardia, which is known for its role in human health and disease. It is primarily associated with opportunistic infections, particularly in immunocompromised individuals. N. aurantia can cause pulmonary infections, cutaneous infections, and central nervous system infections, often leading to significant morbidity in affected patients. The pathogenicity of N. aurantia is attributed to its ability to evade the immune response, utilizing various strategies such as the production of mycolic acids that enhance its survival within macrophages. In terms of antimicrobial resistance, N. aurantia has shown resistance to multiple antibiotics, complicating treatment options. This resistance is often due to the inherent characteristics of the Nocardia species, including the presence of a complex cell wall structure that can impede the action of certain antimicrobial agents. While N. aurantia is not commonly associated with outbreaks, its role in nosocomial infections and its potential to cause severe disease in vulnerable populations underscore its clinical relevance. There is ongoing research into the development of effective therapeutic strategies, including the potential use of specific antibiotics and the role of combination therapy in managing infections caused by this organism. Additionally, understanding the interactions of N. aurantia with the human microbiome may provide insights into its pathogenic mechanisms and potential therapeutic applications.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Nocardia aurantia is a species of actinobacteria commonly found in a variety of terrestrial environments and is particularly associated with soil ecosystems. This microorganism thrives in nutrient-rich soils, often in areas with high organic matter content, such as decaying plant material and compost. Its ability to degrade complex organic compounds allows it to play a significant role in the nutrient cycling process, contributing to soil fertility and health. In addition to its presence in soil, Nocardia aurantia can also be found in aquatic environments, particularly in freshwater systems where organic matter is abundant. Here, it participates in the breakdown of organic pollutants, showcasing its potential in bioremediation efforts. Notably, Nocardia aurantia exhibits a symbiotic relationship with various plants, aiding in the biodegradation of harmful substances in the rhizosphere. This interaction not only benefits the plant by improving soil quality but also enhances the bacterium's survival and proliferation in competitive environments. Furthermore, Nocardia aurantia is known for its resilience to harsh conditions, including drought and high salinity, which allows it to adapt to a range of habitats and maintain its ecological functions even under stress. Its presence in these diverse biomes underscores its importance in maintaining ecological balance and promoting environmental health.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Nocardia aurantia has shown significant potential in various industrial applications. One of the primary areas of interest is in biotechnology, where Nocardia aurantia is utilized for its ability to degrade complex organic compounds. This capability makes it a valuable organism in waste management, particularly in the treatment of industrial effluents and contaminated soils. The organism's enzymatic activity allows it to break down pollutants, contributing to the bioremediation of hazardous waste sites. In the realm of biofuel production, Nocardia aurantia can be involved in the fermentation processes that convert organic materials into biofuels. Its metabolic pathways can be harnessed to enhance the efficiency of converting biomass into usable energy sources, such as biodiesel. Furthermore, Nocardia aurantia has potential applications in pharmaceutical development. Its unique metabolic products may lead to the discovery of novel compounds with antimicrobial properties, which can be further explored for therapeutic uses. The organism's ability to produce secondary metabolites is of particular interest in the search for new drugs. Overall, Nocardia aurantia demonstrates a multifaceted role in biotechnology, waste treatment, biofuel production, and pharmaceutical development, making it a significant microorganism in various industrial sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain variable ✗	gram stain negative ✗	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	false	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	N/A	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	false ✗	false ✗	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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