Amycolatopsis acidicola

General Information

Amycolatopsis acidicola is a fascinating microorganism belonging to the genus Amycolatopsis, which is known for its diverse metabolic capabilities and production of bioactive compounds. One of the most intriguing aspects of A. acidicola is its ability to thrive in highly acidic environments, which is reflected in its name. This acidophilic nature makes it a subject of interest for researchers studying extremophiles and their adaptations to harsh conditions. A. acidicola is particularly notable for its potential in biotechnological applications. The genus Amycolatopsis is renowned for producing a variety of secondary metabolites, including antibiotics, enzymes, and other industrially relevant compounds. The ability of A. acidicola to produce these metabolites in acidic conditions opens up new avenues for industrial processes that require or generate acidic by-products. Moreover, the study of A. acidicola can provide insights into the mechanisms of acid tolerance and survival, which can be applied to improve the robustness of industrial microbial strains. This organism's unique adaptations to low pH environments can also contribute to our understanding of microbial ecology and evolution in extreme habitats. In summary, Amycolatopsis acidicola is a valuable microorganism for scientific research due to its acidophilic nature, potential for biotechnological applications, and the insights it offers into microbial survival in extreme conditions.

Amycolatopsis acidicola is a fascinating actinobacterium that has garnered attention due to its unique ecological niche and potential biotechnological applications. This organism is primarily isolated from acidic environments, such as those found in certain soils and sediments, which makes it particularly interesting for studies on microbial adaptation to extreme conditions. Its ability to thrive in low pH environments suggests that it possesses specialized metabolic pathways and cellular mechanisms that allow it to maintain homeostasis in such challenging habitats. One of the most notable features of A. acidicola is its capacity to produce a variety of secondary metabolites, including antibiotics and other bioactive compounds. This characteristic positions it as a valuable candidate for drug discovery and development, especially in the search for novel antimicrobial agents. The potential for discovering new compounds that can combat antibiotic-resistant bacteria is a significant area of research interest surrounding this organism. Furthermore, A. acidicola contributes to our understanding of microbial diversity and ecology in acidic ecosystems. Its interactions with other microorganisms and its role in nutrient cycling can provide insights into the functioning of these unique environments. Studying this organism can enhance our knowledge of microbial resilience and adaptation, which is crucial in the context of environmental changes and bioremediation efforts. In summary, Amycolatopsis acidicola stands out not only for its ecological significance but also for its potential contributions to biotechnology and medicine, making it a subject of ongoing research and interest in the microbiological community.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Pseudonocardiales

Family: Pseudonocardiaceae

Genus: Amycolatopsis

Species: Amycolatopsis acidicola

NCBI ID

2596893

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/007/713/735/GCF_007713735.2_ASM771373v2

File for sequence-based predictions:
GCF_007713735.2_ASM771373v2_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The actinobacterium Amycolatopsis acidicola has garnered attention due to its potential role in human health and disease. This organism is primarily known for its ability to produce various bioactive compounds, which may have implications in therapeutics and antimicrobial applications. While not traditionally classified as a human pathogen, its presence in certain environments raises questions about its pathogenicity and potential associations with infections in immunocompromised individuals. One of the notable aspects of Amycolatopsis acidicola is its production of secondary metabolites, which can exhibit antimicrobial properties. This characteristic positions it as a candidate for the development of new antibiotics, especially in the context of rising antimicrobial resistance among more common pathogens. Furthermore, the organism's ability to thrive in acidic environments suggests it may have unique metabolic pathways that could be harnessed for biotechnological applications, including the development of probiotics or other health-promoting products. Research into the immune evasion strategies of Amycolatopsis acidicola is still in its infancy, but understanding how it interacts with the human immune system could provide insights into its potential role in disease or health. Overall, while Amycolatopsis acidicola is not widely recognized as a significant human pathogen, its biochemical properties and environmental adaptability warrant further investigation into its clinical implications.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Amycolatopsis acidicola is a species of actinobacteria that thrives in acidic environments, particularly in soils and sediments that are rich in organic matter. This microorganism is commonly found in tropical and subtropical regions, where the soil pH can be significantly lower than neutral, often ranging from 4.0 to 5.5. Its ability to adapt to such extreme pH conditions allows it to occupy a unique ecological niche that few other microorganisms can exploit. In these acidic habitats, A. acidicola plays a crucial role in the decomposition of organic materials, contributing to nutrient cycling and soil health. It is known for its ability to degrade complex organic compounds, which helps in the breakdown of plant litter and other organic debris. This process not only enriches the soil but also supports the growth of other organisms by making nutrients more available. Furthermore, A. acidicola has been observed to engage in symbiotic relationships with various plants, aiding in their nutrient uptake in nutrient-poor soils. This interaction highlights its importance in plant-soil ecosystems, where it can enhance plant growth and resilience in challenging environmental conditions. Overall, Amycolatopsis acidicola exemplifies the intricate connections within acidic biomes, showcasing its adaptability and essential contributions to ecosystem functioning.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Amycolatopsis acidicola has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is utilized for its ability to produce a range of bioactive compounds, including antibiotics and enzymes. This organism is particularly effective in fermentation processes, where it can convert substrates into valuable metabolites, making it a candidate for pharmaceutical development. In the realm of waste management, Amycolatopsis acidicola has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic materials. This property is essential for the treatment of industrial waste, where the microorganism can help in the detoxification and reduction of harmful pollutants. Furthermore, its enzymatic activity is leveraged in biofuel production, where it can assist in the conversion of biomass into fermentable sugars, which are then transformed into biofuels through fermentation. This process not only contributes to sustainable energy solutions but also aids in reducing reliance on fossil fuels. Overall, Amycolatopsis acidicola stands out as a versatile microorganism with applications spanning pharmaceutical development, biotechnology, waste management, and biofuel production, showcasing its importance in modern industrial processes.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	google/gemini-flash-1.5	mistralai/mistral-7b-instruct	google/gemini-pro	perplexity/llama-3-sonar-small-32k-chat	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	google/gemma-7b-it	google/gemma-7b-it	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerotolerant ✗	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	false	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	false	false	true	false	false	true	true	false	false	false	false	false	false	false	false	false	false	false	true	true	true	true	false	false	false	false
Host association	N/A	false	false	false	false	false	true	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Hemolysis	N/A	N/A	N/A	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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