Nocardia kruczakiae

General Information

Nocardia kruczakiae is a fascinating microorganism belonging to the genus Nocardia, which is known for its complex life cycle and ability to degrade a wide range of organic compounds. One of the most intriguing aspects of Nocardia kruczakiae is its role in bioremediation. This organism has been studied for its potential to break down pollutants, including hydrocarbons and other toxic substances, making it valuable for environmental cleanup efforts. Nocardia kruczakiae is also notable for its unique cell wall structure, which contains mycolic acids. These long-chain fatty acids contribute to the organism's resistance to desiccation and chemical damage, allowing it to survive in harsh environments. This resilience makes Nocardia kruczakiae an interesting subject for research into microbial survival mechanisms. In addition to its environmental applications, Nocardia kruczakiae has been studied for its antibiotic production capabilities. Members of the Nocardia genus are known to produce a variety of secondary metabolites with antimicrobial properties, and Nocardia kruczakiae is no exception. This makes it a potential source of new antibiotics, which is particularly important in the face of rising antibiotic resistance. Overall, Nocardia kruczakiae is a microorganism of significant interest due to its bioremediation potential, unique cell wall composition, and antibiotic production. These characteristics make it a valuable subject for ongoing research in environmental science, microbiology, and pharmaceutical development.

Nocardia kruczakiae is a fascinating actinobacterial species that has garnered attention due to its unique ecological niche and potential implications in human health. This microorganism is part of the genus Nocardia, which is known for its ability to thrive in diverse environments, particularly in soil and decaying organic matter. One of the most interesting aspects of N. kruczakiae is its ability to degrade complex organic compounds, making it a valuable player in bioremediation processes. This characteristic allows it to contribute to the breakdown of pollutants, thus playing a role in environmental sustainability. From a research perspective, N. kruczakiae is noteworthy for its secondary metabolite production, which may include bioactive compounds with potential pharmaceutical applications. The exploration of these metabolites could lead to the discovery of new antibiotics or other therapeutic agents, given the increasing concern over antibiotic resistance. Additionally, N. kruczakiae has been studied for its pathogenic potential, particularly in immunocompromised individuals. Understanding its virulence factors and mechanisms of infection can provide insights into the broader category of nocardiosis, a disease caused by various Nocardia species. This aspect makes N. kruczakiae a significant subject of study in medical microbiology, as researchers aim to develop better diagnostic and treatment strategies for infections caused by this organism. In summary, Nocardia kruczakiae stands out due to its ecological role in organic matter degradation, potential for producing valuable bioactive compounds, and its relevance in understanding human disease, making it a compelling subject for ongoing research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Nocardiaceae

Genus: Nocardia

Species: Nocardia kruczakiae

NCBI ID

261477

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/031/457/585/GCA_031457585.1_ASM3145758v1

File for sequence-based predictions:
GCA_031457585.1_ASM3145758v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Nocardia kruczakiae is a member of the genus Nocardia, which is known for its role in human health and disease. This bacterium is primarily associated with pulmonary infections, particularly in immunocompromised individuals. It can cause nocardiosis, a serious infection that may present as pneumonia, brain abscesses, or skin lesions. The pathogenicity of N. kruczakiae is attributed to its ability to evade the immune response through various mechanisms, including the production of mycolic acids that protect it from phagocytosis by immune cells. In terms of antimicrobial resistance, N. kruczakiae has shown resistance to multiple antibiotics, which complicates treatment options. This resistance is often due to the intrinsic properties of the organism, including the presence of efflux pumps and the ability to form biofilms, which can protect it from the effects of antimicrobial agents. While N. kruczakiae is not commonly associated with outbreaks, its role in opportunistic infections highlights the importance of monitoring and understanding its clinical implications, especially in patients with weakened immune systems. There is ongoing research into the potential use of Nocardia species in therapeutics, particularly in the development of novel treatments that could leverage their unique metabolic pathways. However, the clinical relevance of N. kruczakiae remains primarily focused on its pathogenic potential and the challenges it poses in clinical settings.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Nocardia kruczakiae is a species of actinobacteria commonly found in various terrestrial environments and is particularly associated with soil ecosystems. This microorganism thrives in nutrient-rich soils, often in areas with high organic matter content, such as decaying plant material and compost. Its presence is indicative of a healthy soil biome, where it plays a crucial role in the decomposition process and nutrient cycling. In these soil habitats, Nocardia kruczakiae contributes to the breakdown of complex organic compounds, facilitating the release of essential nutrients back into the ecosystem. This process not only supports plant growth but also enhances soil fertility. Additionally, Nocardia kruczakiae exhibits notable interactions with other microorganisms, often engaging in symbiotic relationships with fungi and plants. These interactions can enhance the plant's ability to absorb nutrients, particularly in nutrient-poor soils, showcasing the organism's role in mutualistic associations. Furthermore, this species is known for its ability to adapt to various environmental conditions, including drought and high salinity, which allows it to thrive in diverse habitats. Its resilience and functional capabilities make Nocardia kruczakiae an important player in maintaining the ecological balance within its associated biomes.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Nocardia kruczakiae has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it valuable in biodegradation processes. For instance, Nocardia kruczakiae can be utilized in the treatment of wastewater, where it helps in the breakdown of pollutants, thus contributing to more efficient waste treatment systems. In the realm of biofuel production, Nocardia kruczakiae may play a role in the conversion of organic waste into usable energy sources. Its enzymatic activity can facilitate the breakdown of lignocellulosic materials, which are abundant in agricultural waste, into simpler sugars that can be fermented into biofuels. Moreover, the organism's metabolic pathways are of interest in pharmaceutical development. Certain strains of Nocardia have been studied for their ability to produce bioactive compounds, which could lead to the discovery of new antibiotics or other therapeutic agents. The potential for fermentation processes involving Nocardia kruczakiae could also be explored to enhance the production of these valuable compounds. Overall, Nocardia kruczakiae demonstrates significant promise in environmental biotechnology, particularly in biodegradation and waste management, while also holding potential for advancements in biofuel and pharmaceutical industries.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/gemma-7b-it	google/gemma-7b-it	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	FALSE	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	N/A	gram stain negative ✗	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain variable ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	false	false	false	false
Host association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	false ✗	false ✗	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓
Hemolysis	N/A	N/A	N/A	gamma	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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