Kocuria carniphila

General Information

Kocuria carniphila is a fascinating microorganism belonging to the genus Kocuria, which is part of the family Micrococcaceae. This bacterium is particularly interesting due to its ability to thrive in diverse environments, including those with high salt concentrations. This adaptability makes it a subject of interest for studies on extremophiles and their potential applications in biotechnology. One of the unique aspects of Kocuria carniphila is its association with meat products, from which it was originally isolated. This association suggests that the bacterium may play a role in the spoilage or preservation of meat, making it relevant for food safety and preservation research. Additionally, its presence in such environments indicates that it may possess unique metabolic pathways that allow it to utilize various substrates available in meat. From a research perspective, Kocuria carniphila is valuable due to its potential for producing bioactive compounds. Members of the genus Kocuria have been known to produce antibiotics and other secondary metabolites, which could have significant implications for medical and pharmaceutical applications. The study of Kocuria carniphila could lead to the discovery of new antimicrobial agents or other bioactive molecules. Moreover, the genetic makeup of Kocuria carniphila offers insights into the evolutionary adaptations that enable it to survive in specific niches. Comparative genomics can reveal the genetic basis for its resilience and metabolic versatility, providing a deeper understanding of microbial ecology and evolution. In summary, Kocuria carniphila is a microorganism of considerable interest due to its environmental adaptability, association with meat products, and potential for bioactive compound production. These characteristics make it a valuable subject for research in various fields, including food safety, biotechnology, and microbial ecology.

Kocuria carniphila is a fascinating bacterium belonging to the family Micrococcaceae. This organism is particularly notable for its ability to thrive in extreme environments, which makes it a subject of interest in studies related to extremophiles. Isolated from a meat-processing environment, K. carniphila demonstrates a unique adaptation to nutrient-rich substrates, which can provide insights into microbial survival strategies in high-nutrient conditions. One of the most intriguing aspects of K. carniphila is its potential role in bioremediation. Its capacity to degrade various organic compounds suggests that it could be harnessed for environmental cleanup efforts, particularly in areas contaminated with organic pollutants. This characteristic positions K. carniphila as a valuable candidate for research in microbial ecology and environmental biotechnology. Additionally, K. carniphila has been studied for its antimicrobial properties, which could lead to the development of new antimicrobial agents. The exploration of its metabolic pathways and the compounds it produces may yield novel substances that can combat antibiotic-resistant bacteria, a growing concern in medical microbiology. Overall, Kocuria carniphila stands out not only for its ecological significance but also for its potential applications in biotechnology and medicine, making it a compelling subject for ongoing research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Micrococcales

Family: Micrococcaceae

Genus: Kocuria

Species: Kocuria carniphila

NCBI ID

262208

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/004/136/555/GCF_004136555.1_ASM413655v1

File for sequence-based predictions:
GCF_004136555.1_ASM413655v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Kocuria carniphila is a Gram-positive bacterium that has been increasingly recognized in clinical microbiology. It is part of the normal flora of human skin and mucous membranes but can become opportunistic under certain conditions. Clinical implications of Kocuria carniphila include its association with infections in immunocompromised patients, particularly those with underlying health conditions or those undergoing invasive procedures. It has been implicated in cases of bacteremia, endocarditis, and wound infections, highlighting its potential pathogenicity. One of the notable features of Kocuria carniphila is its antimicrobial resistance profile. It has shown resistance to several commonly used antibiotics, which complicates treatment options. This resistance is often attributed to the acquisition of resistance genes and the ability to form biofilms, which can protect the bacteria from both the host immune response and antimicrobial agents. In terms of immune evasion strategies, Kocuria carniphila can modulate the host's immune response, making it more challenging for the body to eliminate the infection. This includes the production of surface proteins that can interfere with phagocytosis and other immune mechanisms. While Kocuria carniphila is primarily recognized for its pathogenic potential, it is also being studied for its potential medical applications. Some strains may have probiotic properties, contributing to gut health and potentially offering therapeutic benefits. However, more research is needed to fully understand these applications and their implications for human health. Overall, the clinical relevance of Kocuria carniphila underscores the importance of monitoring this organism in clinical settings, especially in patients at risk for opportunistic infections.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Kocuria carniphila is a notable microorganism primarily associated with terrestrial environments and animal-associated habitats. This bacterium is often found in the skin microbiota of mammals, particularly in the microbial communities of carnivorous animals. Its presence in these environments highlights its role in the complex interactions within the skin ecosystem, where it contributes to the maintenance of skin health and microbial balance. In addition to its role on the skin, Kocuria carniphila has been isolated from soil and decaying organic matter, indicating its adaptability to various terrestrial biomes. This adaptability allows it to thrive in nutrient-rich environments, where it can participate in the decomposition process, breaking down organic materials and recycling nutrients back into the ecosystem. Furthermore, Kocuria carniphila exhibits symbiotic relationships with its host organisms, potentially providing benefits such as pathogen resistance and enhanced skin barrier function. Its ability to thrive in diverse environments underscores its ecological significance, as it plays a role in both microbial diversity and ecosystem health.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Kocuria carniphila has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to thrive in diverse environments, which makes it a candidate for several biotechnological processes. In biotechnology, Kocuria carniphila can be utilized in fermentation processes to produce valuable metabolites. Its metabolic pathways allow for the conversion of substrates into useful products, which can be harnessed in the production of food additives or flavor compounds. In the realm of waste management, this microorganism has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic materials. This property is beneficial for the treatment of organic waste, as it can help in the reduction of waste volume and the detoxification of harmful substances, contributing to more sustainable waste management practices. Furthermore, Kocuria carniphila has been explored for its potential in pharmaceutical development. Its unique enzymatic activities may lead to the discovery of novel compounds with antimicrobial properties, which can be significant in the development of new antibiotics or other therapeutic agents. Overall, the versatility of Kocuria carniphila in these applications highlights its importance in advancing industrial processes that are environmentally friendly and economically viable.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-flash-1.5	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openchat/openchat-7b	anthropic/claude-3-haiku:beta	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemini-pro	google/gemini-pro	google/gemma-7b-it	google/gemma-7b-it	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat
Motility	FALSE	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false
Biofilm formation	N/A	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	true	false	false	false	false	false	false	false	false	true	true	false	false	true	true	false	false	true	true	false	false	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	false	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	FALSE	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	coccus	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	bacillus ✗	bacillus ✗	coccus ✓	coccus ✓	coccus ✓	coccus ✓

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