Janthinobacterium violaceinigrum

General Information

Janthinobacterium violaceinigrum is a fascinating microorganism primarily known for its production of the pigment violacein, which gives the bacterium its characteristic violet color. This pigment is not just visually striking but also possesses a range of biological activities, including antibacterial, antiviral, and antifungal properties. These properties make J. violaceinigrum a subject of significant interest in medical and pharmaceutical research, particularly in the development of new antimicrobial agents. Another intriguing aspect of J. violaceinigrum is its potential role in bioremediation. The bacterium has been studied for its ability to degrade various environmental pollutants, including aromatic compounds. This makes it a valuable candidate for cleaning up contaminated environments, contributing to ecological sustainability. Moreover, J. violaceinigrum has been found in diverse habitats, ranging from soil to aquatic environments, indicating its adaptability and resilience. This wide distribution also suggests that the bacterium could play a role in various ecological processes, such as nutrient cycling and the maintenance of microbial community dynamics. In summary, Janthinobacterium violaceinigrum is not only notable for its striking violet pigment but also for its broad-spectrum antimicrobial properties and potential applications in bioremediation. These characteristics make it a valuable organism for both scientific research and practical applications in environmental and medical fields.

Janthinobacterium violaceinigrum is a fascinating bacterium known for its striking violet pigmentation, which is attributed to the production of the pigment violacein. This pigment not only gives the organism its distinctive color but also exhibits antimicrobial properties, making it a subject of interest in the field of natural product research. The ability of J. violaceinigrum to produce violacein has led to investigations into its potential applications in developing new antibiotics, particularly against resistant strains of bacteria. This organism is typically found in soil and aquatic environments, where it plays a role in the degradation of organic matter. Its ecological significance is underscored by its ability to thrive in diverse habitats, contributing to nutrient cycling and soil health. The metabolic versatility of J. violaceinigrum allows it to utilize various carbon sources, which is a valuable trait for biotechnological applications. Moreover, J. violaceinigrum has garnered attention for its potential in bioremediation efforts, particularly in environments contaminated with pollutants. Its capacity to degrade certain toxic compounds positions it as a candidate for environmental cleanup strategies. In addition to its ecological and biotechnological relevance, the study of J. violaceinigrum contributes to our understanding of microbial diversity and the evolutionary adaptations that allow bacteria to thrive in various niches. The unique characteristics of this organism make it a valuable model for research in microbiology, ecology, and biotechnology.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Betaproteobacteria

Order: Burkholderiales

Family: Oxalobacteraceae

Genus: Janthinobacterium

Species: Janthinobacterium violaceinigrum

NCBI ID

2654252

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/009/208/555/GCF_009208555.1_ASM920855v1

File for sequence-based predictions:
GCF_009208555.1_ASM920855v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Janthinobacterium violaceinigrum is a Gram-negative, non-fermentative rod that has garnered attention for its potential clinical implications. It is primarily known for its production of the pigment violacein, which has demonstrated antimicrobial properties against a variety of pathogens, including bacteria and fungi. This characteristic positions J. violaceinigrum as a potential candidate for the development of novel therapeutics aimed at combating infections caused by resistant organisms. In terms of pathogenicity, J. violaceinigrum has been isolated from various environments, including soil and aquatic systems, and has been associated with opportunistic infections, particularly in immunocompromised patients. Its role in human health is still under investigation, but it has been implicated in cases of wound infections and sepsis, highlighting the need for further research into its pathogenic mechanisms and clinical significance. One of the notable features of J. violaceinigrum is its ability to evade the immune response through the production of biofilms, which can protect it from phagocytosis and antibiotic treatment. This biofilm formation is a critical factor in its survival and persistence in clinical settings, particularly in patients with indwelling devices or compromised immune systems. Moreover, the organism's potential for antimicrobial resistance is an area of concern, as it may harbor resistance genes that could complicate treatment options. Understanding the genetic basis of its resistance mechanisms is essential for developing effective strategies to manage infections caused by this organism. In summary, while Janthinobacterium violaceinigrum is not yet widely recognized as a significant human pathogen, its unique properties and associations with infections in vulnerable populations warrant further investigation into its clinical relevance and potential applications in medicine.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Janthinobacterium violaceinigrum is a bacterium commonly found in various freshwater environments, particularly in soil and sediment associated with aquatic ecosystems. This microorganism thrives in nutrient-rich habitats, often in areas with high organic matter content, such as decaying plant material and decomposing organic matter in wetlands and streams. Its presence is frequently noted in biofilms that develop on surfaces submerged in water, where it plays a crucial role in nutrient cycling and organic matter decomposition. In terms of ecological interactions, Janthinobacterium violaceinigrum is known for its ability to produce violet pigments, which can have antimicrobial properties, thus influencing the microbial community structure in its habitat. This bacterium can engage in symbiotic relationships with other microorganisms, contributing to the overall health and stability of the ecosystem. Its metabolic activities can enhance nutrient availability for plants and other organisms, making it an important player in ecosystem functioning. Additionally, Janthinobacterium violaceinigrum exhibits remarkable environmental adaptability, allowing it to survive in varying conditions, including fluctuations in temperature and nutrient levels. This adaptability is essential for its persistence in dynamic environments, such as riverbanks and ponds, where it can respond to changes in water chemistry and organic input. Overall, Janthinobacterium violaceinigrum is a significant component of its ecological niche, contributing to the health and sustainability of freshwater biomes.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Janthinobacterium violaceinigrum has shown significant potential in various industrial applications due to its unique metabolic capabilities and biochemical properties. One of the most notable areas is in biotechnology, where J. violaceinigrum is recognized for its ability to produce the pigment violacein, which has demonstrated antimicrobial and anticancer properties. This pigment can be harnessed in the development of new pharmaceuticals, particularly in the creation of novel drugs that target resistant bacterial strains and cancer cells. In the realm of waste management, J. violaceinigrum has been studied for its capacity to degrade environmental pollutants. Its enzymatic activity allows it to break down complex organic compounds, making it a candidate for bioremediation processes aimed at cleaning contaminated soils and water bodies. This application is particularly relevant in the treatment of industrial effluents and the detoxification of hazardous waste. Furthermore, the organism's role in biofuel production is gaining attention. Through fermentation processes, J. violaceinigrum can convert organic substrates into biofuels, contributing to sustainable energy solutions. Its metabolic pathways can be optimized to enhance the yield of bioethanol or biogas, making it a valuable asset in the renewable energy sector. Overall, Janthinobacterium violaceinigrum exemplifies the intersection of microbiology and industrial innovation, with its applications spanning pharmaceutical development, waste treatment, and biofuel production, showcasing its versatility and importance in modern biotechnology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	perplexity/llama-3-sonar-small-32k-chat	meta-llama/llama-3-70b-instruct:nitro	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	true	false	true	false	false	false	false	true	true	false	false	false	false	false	false	true	true	false	false	true	true	true	true	false	false
Biofilm formation	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	true	true	false	false	true	false	true	false	false	true	true	false	false	true	true	false	false	true	true	true	true	false	false	true	true	false	false
Host association	FALSE	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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