Bartonella refiksaydamii

General Information

Bartonella refiksaydamii is a fascinating microorganism belonging to the genus Bartonella, which is known for its complex interactions with mammalian hosts. One of the most intriguing aspects of B. refiksaydamii is its ability to establish chronic infections in its hosts, often leading to persistent bacteremia. This characteristic makes it a valuable subject for studying host-pathogen interactions and the mechanisms of chronic infection. Another unique feature of B. refiksaydamii is its potential role in zoonotic diseases. Members of the Bartonella genus are often transmitted through vectors such as fleas, lice, and ticks, and can infect a wide range of mammalian hosts, including humans. This makes B. refiksaydamii particularly interesting for research into vector-borne diseases and the epidemiology of zoonotic infections. From a genetic perspective, B. refiksaydamii possesses a relatively small genome, which is typical of Bartonella species. This compact genome encodes a variety of virulence factors, including type IV secretion systems, which are crucial for the bacterium's ability to invade and survive within host cells. The study of these virulence factors can provide insights into bacterial pathogenesis and potential targets for therapeutic intervention. In addition, B. refiksaydamii has been observed to exhibit a high degree of genetic diversity, which may contribute to its adaptability and persistence in different hosts and environments. This genetic variability is a key area of interest for researchers looking to understand the evolutionary dynamics of pathogenic bacteria. Overall, Bartonella refiksaydamii is a microorganism of significant interest due to its chronic infection capabilities, zoonotic potential, compact yet complex genome, and genetic diversity. These characteristics make it a valuable model for studying bacterial pathogenesis, host-pathogen interactions, and the development of new therapeutic strategies.

Bartonella refiksaydamii is a recently identified species within the genus Bartonella, which is known for its role in various zoonotic diseases. This organism is particularly interesting due to its potential association with vector-borne diseases, as many members of the Bartonella genus are transmitted by arthropods, such as fleas and ticks. The unique ecological niche it occupies may provide insights into the evolutionary adaptations of bacteria that thrive in complex host environments. One of the most notable aspects of B. refiksaydamii is its genetic diversity, which can lead to variations in pathogenicity and host specificity. This diversity makes it a valuable subject for research into host-pathogen interactions and the mechanisms by which these bacteria evade the immune response of their hosts. Understanding these interactions can have significant implications for developing treatments and preventive measures against diseases caused by Bartonella species. Furthermore, the study of B. refiksaydamii may contribute to the broader understanding of bacterial evolution and the dynamics of microbial communities in various ecosystems. Its discovery highlights the importance of exploring less-studied microorganisms, which can reveal new insights into microbial ecology and the potential for undiscovered pathogenic mechanisms. Overall, Bartonella refiksaydamii represents a fascinating area of study for microbiologists and epidemiologists alike, with implications for both human and animal health.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Alphaproteobacteria

Order: Hyphomicrobiales

Family: Bartonellaceae

Genus: Bartonella

Species: Bartonella refiksaydamii

NCBI ID

2654951

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/902/652/675/GCA_902652675.1_B191

File for sequence-based predictions:
GCA_902652675.1_B191_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Bartonella refiksaydamii is a member of the genus Bartonella, which is known for its association with various infections in humans. While specific clinical implications of B. refiksaydamii are still being studied, it is closely related to other species within the genus that have well-documented roles in human health and disease. Bartonella species are often implicated in conditions such as Bartonellosis, which can manifest as fever, lymphadenopathy, and endocarditis. The pathogenicity of B. refiksaydamii may involve similar mechanisms of immune evasion, including the ability to survive within red blood cells and evade the host's immune response. Furthermore, some Bartonella species exhibit antimicrobial resistance, complicating treatment options for infections. The potential for B. refiksaydamii to contribute to zoonotic transmission from animal reservoirs to humans is also a concern, as it may be transmitted through vectors such as fleas or ticks. In terms of medical applications, while B. refiksaydamii itself may not yet have established therapeutic uses, the study of Bartonella species has led to the exploration of probiotics and vaccines targeting related pathogens. Continued research into B. refiksaydamii is essential to fully understand its clinical relevance, particularly in the context of emerging infectious diseases and the evolving landscape of antimicrobial resistance.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Bartonella refiksaydamii has garnered attention for its potential applications in various industrial sectors, particularly in biotechnology and pharmaceutical development. This organism is known for its unique metabolic pathways, which can be harnessed for the production of bioactive compounds. For instance, it may be involved in the fermentation processes that yield valuable metabolites, such as antimicrobial agents, which can be utilized in drug formulation. In the realm of waste management, Bartonella refiksaydamii has shown promise in biodegradation processes, where it can help in the breakdown of complex organic materials, thus contributing to the treatment of wastewater and the reduction of environmental pollutants. Its enzymatic activity may facilitate the degradation of specific contaminants, making it a candidate for bioremediation efforts. Moreover, the organism's role in biofuel production is an area of interest, as its metabolic capabilities could be explored for the conversion of biomass into biofuels through fermentation processes. This could lead to more sustainable energy solutions by utilizing waste materials as feedstock. Overall, while research on Bartonella refiksaydamii is still emerging, its potential applications in biotechnology, waste management, and biofuel production highlight its significance in addressing contemporary industrial challenges.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 11

LLM predicted phenotypes: 2

Phenotype	High-quality annotation	google/gemini-flash-1.5	mistralai/mistral-7b-instruct	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro	google/gemini-pro	openai/gpt-4o	openai/gpt-4o	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	aerotolerant ✗	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	alpha ✗	alpha ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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