Actinomadura litoris

General Information

Actinomadura litoris is a fascinating microorganism belonging to the genus Actinomadura. This genus is known for its complex life cycle and the production of a wide array of secondary metabolites, many of which have significant pharmaceutical applications. One of the most intriguing aspects of A. litoris is its ability to produce novel antibiotics and bioactive compounds. These compounds have shown potential in combating multi-drug resistant pathogens, making A. litoris a valuable subject of study in the field of medical microbiology and drug discovery. Actinomadura litoris was originally isolated from a marine environment, which adds to its uniqueness. Marine-derived actinomycetes are less explored compared to their terrestrial counterparts, and they often produce unique metabolites due to the distinct conditions of their habitat. The marine origin of A. litoris suggests that it may possess unique enzymatic pathways and metabolic capabilities that are not found in terrestrial actinomycetes. Another interesting feature of A. litoris is its potential role in bioremediation. The ability of this microorganism to degrade complex organic compounds makes it a candidate for cleaning up polluted environments, particularly those contaminated with hydrocarbons and other persistent organic pollutants. This environmental application further underscores the importance of studying A. litoris. In summary, Actinomadura litoris is a microorganism of significant interest due to its antibiotic production, unique marine-derived metabolites, and potential applications in bioremediation. Its study not only contributes to our understanding of microbial diversity and ecology but also holds promise for practical applications in medicine and environmental science.

Actinomadura litoris is a fascinating species of actinobacteria that was first isolated from marine sediment. This organism is particularly interesting due to its unique habitat, thriving in coastal environments, which sets it apart from many other actinobacteria typically found in soil or freshwater. The ability of A. litoris to adapt to saline conditions highlights its potential for biotechnological applications in marine biotechnology and bioremediation processes. One of the most notable characteristics of Actinomadura litoris is its production of bioactive compounds. This species has been shown to synthesize various secondary metabolites, including antibiotics and antifungal agents, which are of great interest in pharmaceutical research. The discovery of novel compounds from marine actinobacteria like A. litoris could lead to the development of new drugs, especially in the face of rising antibiotic resistance. Furthermore, A. litoris contributes to our understanding of marine microbial ecology. Its interactions with other microorganisms and its role in nutrient cycling within marine sediments provide valuable insights into the dynamics of coastal ecosystems. The study of Actinomadura litoris not only enhances our knowledge of microbial diversity but also underscores the importance of marine environments as reservoirs of novel microbial species with potential applications in various fields, including medicine and environmental science.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Streptosporangiales

Family: Thermomonosporaceae

Genus: Actinomadura

Species: Actinomadura litoris

NCBI ID

2678616

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/009/733/595/GCF_009733595.1_ASM973359v1

File for sequence-based predictions:
GCF_009733595.1_ASM973359v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Actinomadura litoris is a member of the Actinobacteria phylum and is primarily known for its role in the environment, particularly in marine ecosystems. However, its clinical implications are becoming increasingly relevant. Actinomadura litoris has been associated with cutaneous infections in humans, particularly in immunocompromised individuals. These infections can manifest as soft tissue infections or wound infections, often requiring medical intervention. One of the notable aspects of Actinomadura litoris is its potential for antimicrobial resistance. Strains of this organism have shown resistance to multiple classes of antibiotics, which complicates treatment options for infections. This resistance is particularly concerning in the context of rising global antibiotic resistance trends, making it essential for healthcare providers to be aware of its potential as a pathogen. In terms of immune evasion, Actinomadura litoris may employ various strategies to survive within the host, including the production of biofilms, which can protect it from both the host's immune response and antibiotic treatment. While research on Actinomadura litoris is still emerging, its identification in clinical settings underscores the need for ongoing surveillance and further studies to understand its pathogenic mechanisms and potential therapeutic targets. Overall, the clinical relevance of Actinomadura litoris highlights the importance of recognizing environmental microorganisms as potential human pathogens.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Actinomadura litoris is a filamentous bacterium commonly found in marine environments, particularly in coastal sediments and intertidal zones. This organism thrives in saline conditions, often associated with decaying organic matter and nutrient-rich substrates. Its ability to degrade complex organic compounds makes it a vital player in the nutrient cycling processes within these ecosystems. In these marine biomes, A. litoris exhibits notable interactions with its surroundings, including symbiotic relationships with other microorganisms. It can form associations with fungi and other bacteria, contributing to the overall health and stability of the microbial community. This bacterium is also known for its role in the degradation of pollutants, thus aiding in bioremediation efforts in contaminated coastal areas. Furthermore, A. litoris demonstrates remarkable environmental adaptation capabilities, allowing it to survive in varying salinity levels and fluctuating temperatures typical of intertidal habitats. Its presence in these ecosystems underscores its importance in maintaining ecological balance and promoting biodiversity within marine biomes.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Actinomadura litoris has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where Actinomadura litoris is recognized for its ability to produce a range of bioactive compounds, including antibiotics and enzymes. This capability is particularly valuable in the development of new pharmaceuticals, as the organism can be harnessed for fermentation processes to yield these compounds efficiently. In the realm of waste management, Actinomadura litoris has demonstrated effectiveness in biodegradation processes. It can break down complex organic materials, making it useful in the treatment of wastewater and the remediation of contaminated environments. This biodegradative ability is crucial for reducing environmental pollutants and enhancing the sustainability of waste management practices. Additionally, Actinomadura litoris has potential applications in biofuel production. Its metabolic pathways can be utilized to convert biomass into biofuels through fermentation, contributing to renewable energy solutions. The organism's enzymatic activity can facilitate the breakdown of lignocellulosic materials, which are abundant in agricultural waste, into fermentable sugars that can be further processed into biofuels. Overall, Actinomadura litoris stands out as a versatile microorganism with promising applications in pharmaceutical development, waste management, and biofuel production, showcasing its importance in advancing industrial biotechnology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/palm-2-chat-bison-32k	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	google/gemini-pro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	false	true	true	true	false	true	false	true	true	true	true	false	false	true	true	true	true	false	false	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	true	true	true	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	true	true	false	false
Host association	N/A	false	true	false	false	true	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Hemolysis	N/A	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

Back to Search