Nocardia barduliensis

General Information

Nocardia barduliensis is a fascinating microorganism belonging to the genus Nocardia, which is known for its complex life cycle and ability to degrade a wide range of organic compounds. One of the most noteworthy characteristics of Nocardia barduliensis is its role in bioremediation. This species has shown a remarkable ability to break down pollutants, including hydrocarbons and other toxic substances, making it a valuable asset in environmental cleanup efforts. Another unique feature of Nocardia barduliensis is its production of secondary metabolites. These compounds have potential applications in pharmaceuticals, including antibiotics and anticancer agents. The metabolic versatility of this organism is of great interest to researchers looking to discover new bioactive compounds. From a genetic perspective, Nocardia barduliensis possesses a large and complex genome, which provides insights into its adaptability and survival mechanisms in various environments. This genetic complexity also makes it a model organism for studying gene regulation and expression in actinomycetes. In summary, Nocardia barduliensis is a microorganism of significant interest due to its bioremediation capabilities, production of valuable secondary metabolites, and genetic complexity. These characteristics make it a valuable subject for research in environmental science, biotechnology, and pharmaceuticals.

Nocardia barduliensis is a species of the genus Nocardia, which is known for its unique filamentous structure and its ability to thrive in diverse environments. This organism is particularly interesting due to its opportunistic pathogenicity, which can lead to infections in immunocompromised individuals. The species was first described in 2016 and has since been recognized for its resistance to multiple antibiotics, making it a subject of interest in medical research, especially in the context of developing new therapeutic strategies against resistant pathogens. One of the most notable characteristics of N. barduliensis is its ability to degrade a variety of organic compounds, which positions it as a potential candidate for bioremediation applications. This capability allows it to break down pollutants in contaminated environments, contributing to ecological restoration efforts. Furthermore, the organism's metabolic versatility is a focal point for researchers studying microbial ecology and the role of actinobacteria in nutrient cycling. In addition to its environmental significance, N. barduliensis has been studied for its secondary metabolite production, which may include bioactive compounds with potential pharmaceutical applications. The exploration of these metabolites could lead to the discovery of new drugs or therapeutic agents, highlighting the organism's value in the field of natural product chemistry. Overall, Nocardia barduliensis stands out not only for its clinical implications but also for its ecological and biotechnological potential, making it a fascinating subject for ongoing research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Nocardiaceae

Genus: Nocardia

Species: Nocardia barduliensis

NCBI ID

2736643

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/013/315/795/GCA_013315795.1_ASM1331579v1

File for sequence-based predictions:
GCA_013315795.1_ASM1331579v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Nocardia barduliensis is a member of the genus Nocardia, which is known for its role in human health and disease. It is primarily associated with pulmonary infections and can lead to nocardiosis, a serious condition that often affects immunocompromised individuals. The clinical implications of N. barduliensis include its potential to cause cutaneous infections, central nervous system infections, and systemic disease, particularly in patients with weakened immune systems, such as those with HIV/AIDS or those undergoing immunosuppressive therapy. One of the notable features of N. barduliensis is its pathogenicity, which is attributed to its ability to evade the immune response through various mechanisms, including the production of mycolic acids that help it resist phagocytosis by immune cells. This ability to survive and replicate within macrophages is a key factor in its virulence. In terms of antimicrobial resistance, N. barduliensis has shown resistance to several common antibiotics, which complicates treatment options. It is often resistant to beta-lactams and may require the use of alternative antibiotics such as sulfonamides or tetracyclines for effective management of infections. While N. barduliensis is not commonly associated with outbreaks, its presence in clinical settings highlights the importance of recognizing and diagnosing nocardiosis, especially in at-risk populations. Understanding the clinical implications of N. barduliensis is crucial for effective treatment and management of infections caused by this organism.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Nocardia barduliensis is a species of actinobacteria that is primarily associated with soil environments and decaying organic matter. This microorganism thrives in aerobic conditions, often found in nutrient-rich substrates where it plays a crucial role in the decomposition process. Its presence is particularly noted in temperate and tropical biomes, where it contributes to nutrient cycling and soil health. In these soil habitats, Nocardia barduliensis engages in symbiotic relationships with various plants, aiding in the breakdown of complex organic materials and enhancing nutrient availability. This interaction is vital for the growth of certain plant species, particularly in nutrient-poor soils, where the bacterium helps to mobilize essential nutrients such as nitrogen and phosphorus. Additionally, Nocardia barduliensis is known for its ability to degrade a variety of organic pollutants, making it an important player in bioremediation processes. This capability allows it to thrive in contaminated environments, where it can help restore ecological balance by breaking down harmful substances. Overall, Nocardia barduliensis exemplifies the intricate relationships within soil ecosystems, highlighting its role in both nutrient cycling and environmental remediation.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Nocardia barduliensis has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This actinobacterium is known for its ability to degrade complex organic compounds, making it a valuable player in biodegradation processes. Its enzymatic activity allows it to break down pollutants, which can be harnessed for effective waste treatment in contaminated environments, such as soil and water. In the realm of biotechnology, Nocardia barduliensis can be utilized in the production of specific enzymes that are crucial for various industrial processes. These enzymes can facilitate fermentation processes, enhancing the efficiency of biofuel production by converting biomass into fermentable sugars. This capability positions the organism as a potential candidate for sustainable energy solutions. Moreover, the unique metabolic pathways of Nocardia barduliensis may lead to the discovery of novel compounds with pharmaceutical properties, contributing to the development of new drugs. Its role in the production of bioactive metabolites can be explored further in the context of pharmaceutical development, where it may provide leads for antibiotic or anticancer agents. Overall, Nocardia barduliensis presents a multifaceted opportunity for innovation across several industries, particularly in enhancing environmental sustainability and advancing health-related research.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro-1.5	google/gemini-flash-1.5	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	google/gemini-pro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biosafety level	N/A	biosafety level 2	biosafety level 2	biosafety level 3	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 3	biosafety level 3
Health association	N/A	true	true	true	true	true	true	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓
Hemolysis	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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