Staphylococcus caledonicus

General Information

Staphylococcus caledonicus is a relatively lesser-known member of the Staphylococcus genus, which includes several species of significant medical and industrial importance. One of the most intriguing aspects of S. caledonicus is its potential role in the environment and its interactions with other microorganisms. This species has been isolated from various environmental sources, suggesting it may play a role in natural microbial communities. Its ability to adapt to different environmental conditions makes it a subject of interest for studies on microbial ecology and environmental microbiology. From a research perspective, S. caledonicus is valuable due to its genetic makeup, which can provide insights into the evolutionary pathways of the Staphylococcus genus. Comparative genomic studies involving S. caledonicus can help identify unique genes and metabolic pathways that differentiate it from other, more pathogenic Staphylococcus species, such as S. aureus. Moreover, understanding the metabolic capabilities of S. caledonicus could lead to the discovery of novel enzymes or bioactive compounds with potential applications in biotechnology and medicine. For instance, enzymes that can degrade environmental pollutants or novel antimicrobial compounds that could be used to combat antibiotic-resistant bacteria. In summary, Staphylococcus caledonicus is an interesting organism due to its environmental adaptability, genetic uniqueness, and potential applications in various scientific fields. Its study not only enhances our understanding of microbial diversity but also opens up new avenues for biotechnological innovation.

Staphylococcus caledonicus is a relatively lesser-known species within the Staphylococcus genus, which is renowned for its diverse range of pathogenic and non-pathogenic members. This organism was first isolated from human clinical samples, highlighting its potential relevance in medical microbiology. What makes S. caledonicus particularly interesting is its unique genetic makeup and its potential role in human health. One of the notable characteristics of S. caledonicus is its ability to produce certain enzymes that may contribute to its survival in various environments, including the human body. This enzymatic activity can influence its interactions with host tissues and the immune system, making it a subject of interest for researchers studying host-pathogen dynamics. Furthermore, S. caledonicus has been identified in specific geographical regions, which raises questions about its ecological niche and evolutionary adaptations. Understanding the distribution and genetic diversity of this species can provide insights into the evolution of staphylococci and their adaptation to different environments. From a research perspective, S. caledonicus serves as a valuable model for studying the mechanisms of antibiotic resistance, as it may share genetic traits with more well-known resistant strains like Staphylococcus aureus. Investigating its resistance patterns could lead to a better understanding of how staphylococci evolve and adapt to antibiotic pressures, which is crucial in the context of rising antibiotic resistance globally. In summary, Staphylococcus caledonicus is a fascinating organism that offers a window into the complexities of microbial life, host interactions, and the ongoing challenges posed by antibiotic resistance. Its unique characteristics and potential implications for human health make it a significant subject for further research.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Bacilli

Order: Bacillales

Family: Staphylococcaceae

Genus: Staphylococcus

Species: Staphylococcus caledonicus

NCBI ID

2741333

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/016/238/465/GCA_016238465.1_ASM1623846v1

File for sequence-based predictions:
GCA_016238465.1_ASM1623846v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Staphylococcus caledonicus is a coagulase-negative staphylococcus (CoNS) that has been identified in various clinical settings, particularly in association with infections in immunocompromised patients. While it is generally considered a part of the normal skin flora, its role as a potential pathogen has gained attention due to its ability to cause nosocomial infections and its association with biofilm formation on medical devices, which can lead to persistent infections that are difficult to treat. Clinical relevance includes its potential to cause bacteremia, endocarditis, and wound infections, particularly in patients with underlying health conditions or those undergoing invasive procedures. The organism's pathogenicity is partly attributed to its ability to evade the immune response, utilizing various strategies such as the production of extracellular polysaccharide and protein A, which can inhibit opsonization and phagocytosis. Moreover, S. caledonicus has shown antimicrobial resistance, particularly to methicillin, which complicates treatment options. This resistance is often linked to the acquisition of mecA gene, making it a concern in healthcare settings where antibiotic stewardship is critical. In terms of medical applications, while S. caledonicus is not typically used as a probiotic or therapeutic agent, understanding its behavior and resistance mechanisms is essential for developing effective treatment protocols and infection control measures in clinical environments. Continued surveillance and research are necessary to fully elucidate its role in human health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Staphylococcus caledonicus is a species of bacteria that is primarily associated with marine environments and coastal ecosystems. This microorganism has been isolated from various habitats, particularly in areas where saltwater is prevalent, indicating its adaptation to high salinity conditions. It thrives in intertidal zones and rock pools, where it can be found on the surfaces of rocks and other substrates exposed to seawater. In these environments, Staphylococcus caledonicus plays a crucial role in nutrient cycling, contributing to the breakdown of organic matter and influencing the microbial community structure. Its presence can affect the availability of nutrients for other organisms, thereby impacting the overall health of the ecosystem. Additionally, this bacterium may engage in symbiotic relationships with other marine organisms, potentially aiding in their survival by providing essential nutrients or enhancing their resistance to environmental stressors. The ability of Staphylococcus caledonicus to withstand varying salinity levels demonstrates its remarkable environmental adaptation, allowing it to thrive in fluctuating conditions typical of coastal habitats. Overall, the ecological niche of Staphylococcus caledonicus is characterized by its association with marine habitats, its role in nutrient cycling, and its interactions with other organisms in the ecosystem.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Staphylococcus caledonicus has shown potential in various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This organism is known for its ability to produce certain enzymes that can be harnessed in biocatalysis, which is crucial for the synthesis of various chemical compounds. For instance, the enzymatic activity of Staphylococcus caledonicus can be utilized in the production of bioactive compounds that have therapeutic properties, making it a candidate for drug development. In the realm of waste management, Staphylococcus caledonicus has been studied for its role in biodegradation processes. This microorganism can contribute to the breakdown of organic waste materials, thereby aiding in the treatment of wastewater and reducing environmental pollution. Its metabolic pathways can be leveraged to enhance the efficiency of bioremediation efforts, particularly in environments contaminated with organic pollutants. Moreover, there is potential for Staphylococcus caledonicus in the production of biofuels. Through fermentation processes, this microorganism can convert biomass into bioethanol, providing a sustainable alternative to fossil fuels. The efficiency of its fermentation pathways can be optimized to increase yield and reduce production costs, making it a valuable asset in the renewable energy sector. Overall, Staphylococcus caledonicus presents a multifaceted opportunity for innovation across various industries, particularly in biotechnology, waste management, and biofuel production, through its unique enzymatic capabilities and metabolic processes.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	meta-llama/llama-3-8b-instruct:nitro	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	anthropic/claude-3-haiku:beta	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	google/gemini-pro	anthropic/claude-3.5-sonnet	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	mistralai/mistral-7b-instruct	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerotolerant ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Biosafety level	N/A	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2
Health association	N/A	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	beta	beta	gamma	gamma	alpha	alpha	alpha	gamma	gamma	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	bacillus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus	coccus

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