Nocardia gipuzkoensis

General Information

Nocardia gipuzkoensis is a fascinating microorganism belonging to the genus Nocardia, which is known for its complex life cycle and ability to degrade a wide range of organic compounds. One of the most intriguing aspects of Nocardia gipuzkoensis is its role in bioremediation. This species has shown potential in breaking down pollutants, making it valuable for environmental cleanup efforts. Nocardia gipuzkoensis is also notable for its production of secondary metabolites, which can have antibiotic properties. This makes it a subject of interest in pharmaceutical research, as these compounds could lead to the development of new antibiotics or other therapeutic agents. Additionally, the organism's unique cell wall structure, which contains mycolic acids, contributes to its resilience and ability to survive in harsh environments. This characteristic is not only interesting from a microbiological perspective but also has implications for understanding pathogenicity and developing treatments for infections caused by Nocardia species. In summary, Nocardia gipuzkoensis is a microorganism of significant interest due to its bioremediation capabilities, production of potentially valuable secondary metabolites, and unique structural features that contribute to its survival and pathogenicity.

Nocardia gipuzkoensis is a notable species within the genus Nocardia, which is known for its filamentous, aerobic actinobacteria. This organism is particularly interesting due to its environmental versatility and its ability to thrive in various habitats, including soil and decaying organic matter. Its unique metabolic capabilities allow it to degrade complex organic compounds, making it valuable in bioremediation efforts, where it can help in the breakdown of pollutants and contaminants in the environment. One of the most significant aspects of Nocardia gipuzkoensis is its pathogenic potential. While many species in the Nocardia genus are opportunistic pathogens, N. gipuzkoensis has been associated with infections in immunocompromised individuals. This highlights the importance of understanding its virulence factors and mechanisms of infection, which can contribute to the broader field of medical microbiology and the development of therapeutic strategies. Additionally, the organism's genetic diversity and adaptability make it a subject of interest for researchers studying microbial evolution and ecology. Its ability to survive in harsh conditions and its interactions with other microorganisms in the environment can provide insights into microbial community dynamics and resilience. In summary, Nocardia gipuzkoensis stands out due to its dual role as both a potential bioremediation agent and an opportunistic pathogen, making it a valuable organism for research in both environmental and clinical microbiology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Nocardiaceae

Genus: Nocardia

Species: Nocardia gipuzkoensis

NCBI ID

2749991

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/021/183/645/GCA_021183645.1_ASM2118364v1

File for sequence-based predictions:
GCA_021183645.1_ASM2118364v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Nocardia gipuzkoensis is a member of the genus Nocardia, which is known for its role in human health and disease. It is primarily associated with pulmonary infections and can lead to nocardiosis, a serious condition that often affects immunocompromised individuals. The clinical implications of N. gipuzkoensis include its potential to cause cutaneous infections, central nervous system infections, and systemic disease, particularly in patients with weakened immune systems, such as those with HIV/AIDS or undergoing immunosuppressive therapy. One of the notable features of N. gipuzkoensis is its ability to evade the immune response through various mechanisms, including the production of mycolic acids that help it resist phagocytosis by immune cells. This pathogenicity is a significant concern in clinical settings, as it can lead to delayed diagnosis and treatment. In terms of antimicrobial resistance, N. gipuzkoensis has shown resistance to multiple antibiotics, which complicates treatment options. The organism is typically sensitive to sulfonamides, but resistance patterns can vary, necessitating susceptibility testing for effective management of infections. While N. gipuzkoensis is primarily recognized for its pathogenic potential, there is ongoing research into its role in the human microbiome and its potential applications in biotechnology. However, its clinical relevance remains predominantly associated with its pathogenicity and the challenges it poses in treating nocardiosis.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Nocardia gipuzkoensis is a species of actinobacteria that is primarily associated with soil environments and decaying organic matter. This microorganism thrives in aerobic conditions, often found in nutrient-rich substrates where it plays a crucial role in the decomposition of organic materials. Its presence is particularly noted in temperate and subtropical regions, where it contributes to the cycling of nutrients within the ecosystem. In terms of ecological interactions, Nocardia gipuzkoensis is known for its ability to degrade complex organic compounds, which aids in the breakdown of pollutants and enhances soil fertility. This organism can also form symbiotic relationships with plants, promoting plant health by improving nutrient availability in the soil. Furthermore, Nocardia gipuzkoensis exhibits notable environmental adaptations, allowing it to survive in various conditions, including those with limited moisture. Its resilience and metabolic versatility make it an important player in soil microbiomes, where it interacts with other microorganisms, contributing to the overall biodiversity and stability of the ecosystem. Overall, Nocardia gipuzkoensis exemplifies the intricate relationships within terrestrial biomes, highlighting its significance in ecological processes.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Nocardia gipuzkoensis has shown significant potential in various industrial applications, particularly in the fields of biotechnology and waste management. This actinobacterium is known for its ability to degrade a wide range of organic pollutants, making it a valuable asset in biodegradation processes. For instance, it has been utilized in the treatment of wastewater containing complex organic compounds, effectively breaking them down and reducing environmental impact. In the realm of biofuel production, Nocardia gipuzkoensis can contribute to the conversion of biomass into biofuels through its metabolic pathways that facilitate the breakdown of lipids and other organic materials. This process can enhance the efficiency of fermentation techniques used in biofuel generation. Moreover, the organism has been studied for its potential in pharmaceutical development, particularly in the production of bioactive compounds. Its unique enzymatic activities can lead to the synthesis of novel antibiotics and other therapeutic agents, showcasing its importance in the pharmaceutical industry. Overall, Nocardia gipuzkoensis exemplifies a versatile microorganism with applications spanning from waste treatment to enzyme production, highlighting its role in promoting sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	aerobic	N/A	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	false	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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