Limosilactobacillus fastidiosus

General Information

Limosilactobacillus fastidiosus is a fascinating microorganism that belongs to the lactic acid bacteria group. One of the key characteristics of this species is its ability to produce lactic acid through the fermentation of carbohydrates, which makes it valuable in various industrial and food applications. This bacterium is particularly interesting due to its fastidious growth requirements, which means it requires specific nutrients and environmental conditions to thrive. This trait makes L. fastidiosus an excellent model organism for studying nutrient uptake and metabolic pathways in lactic acid bacteria. Another unique aspect of Limosilactobacillus fastidiosus is its potential use in probiotic formulations. Its ability to survive in the gastrointestinal tract and contribute to the balance of gut microbiota highlights its importance in health and nutrition research. Moreover, L. fastidiosus has been studied for its role in biopreservation. The lactic acid and other antimicrobial compounds it produces can inhibit the growth of spoilage organisms and pathogens, thereby extending the shelf life of perishable products. In summary, Limosilactobacillus fastidiosus is a microorganism of significant interest due to its stringent growth requirements, potential probiotic benefits, and applications in food preservation. Its unique characteristics make it a valuable subject for ongoing research in microbiology and biotechnology.

Limosilactobacillus fastidiosus is a fascinating species of lactic acid bacteria that has garnered attention for its unique metabolic capabilities and ecological significance. This organism is primarily known for its role in the fermentation of various food products, particularly in the production of dairy and plant-based fermented foods. Its ability to thrive in environments with low nutrient availability makes it particularly interesting for researchers studying microbial ecology and fermentation processes. One of the standout features of L. fastidiosus is its specialized fermentation pathways, which allow it to utilize a variety of carbohydrates that are often not accessible to other lactic acid bacteria. This characteristic not only enhances its survival in competitive environments but also contributes to the diversity of flavors and textures in fermented foods. The metabolic versatility of this species is a valuable asset in the food industry, where it can be harnessed to develop novel fermentation products. Additionally, Limosilactobacillus fastidiosus has been studied for its potential health benefits. Some strains are believed to possess probiotic properties, which may contribute to gut health and overall well-being. This aspect opens up avenues for research into its application in functional foods and dietary supplements. Furthermore, the organism's genome has been sequenced, providing insights into its genetic makeup and the specific genes responsible for its unique metabolic traits. This genomic information is crucial for biotechnological applications, as it allows for the potential engineering of strains with enhanced properties for industrial fermentation processes. The ongoing research into L. fastidiosus not only highlights its importance in food science but also its potential contributions to health and nutrition.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Bacilli

Order: Lactobacillales

Family: Lactobacillaceae

Genus: Limosilactobacillus

Species: Limosilactobacillus fastidiosus

NCBI ID

2759855

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/014/145/425/GCA_014145425.1_ASM1414542v1

File for sequence-based predictions:
GCA_014145425.1_ASM1414542v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Limosilactobacillus fastidiosus is a member of the lactic acid bacteria group and is primarily known for its role in the human gut microbiome. It is considered a beneficial bacterium that contributes to gut health by aiding in the fermentation of dietary fibers and the production of short-chain fatty acids, which are important for maintaining intestinal health and immune function. While L. fastidiosus is generally regarded as non-pathogenic, its presence in the gut can be associated with various health benefits, including the potential to enhance the immune response and reduce the risk of certain gastrointestinal disorders. However, there is limited documentation regarding its direct involvement in disease associations or pathogenicity in humans. In terms of antimicrobial resistance, there is currently no significant evidence suggesting that L. fastidiosus possesses resistance mechanisms that would pose a threat to human health. Its role as a probiotic candidate is being explored, with potential applications in the development of therapeutics aimed at restoring gut microbiota balance, particularly after antibiotic treatment. Overall, while L. fastidiosus is not directly linked to any known outbreaks or infections, its contributions to gut health and potential therapeutic applications underscore its relevance in the field of microbiome research and probiotic therapy.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Limosilactobacillus fastidiosus is a species of lactic acid bacteria commonly found in various fermented food products and the gastrointestinal tracts of animals, particularly in the intestines of mammals. This microorganism thrives in environments that are rich in carbohydrates, where it plays a crucial role in the fermentation process. Its primary ecological niche includes the gut microbiome, where it contributes to the digestion of complex carbohydrates and the production of lactic acid, which helps maintain a balanced pH and inhibits the growth of pathogenic bacteria. In addition to its presence in the gut, Limosilactobacillus fastidiosus is also associated with dairy products, where it aids in the fermentation of milk into yogurt and cheese. This process not only enhances the flavor and texture of these products but also increases their nutritional value by making certain nutrients more bioavailable. Notably, this bacterium can engage in symbiotic relationships with other gut microbiota, contributing to a healthy microbiome and supporting the host's immune system. Its ability to adapt to varying pH levels and temperatures makes it a resilient organism in both natural and industrial fermentation processes. Overall, Limosilactobacillus fastidiosus plays a significant role in both ecological and agricultural contexts, highlighting its importance in maintaining the health of both ecosystems and food systems.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Limosilactobacillus fastidiosus has shown significant potential in various industrial applications. One of the primary areas of interest is in biotechnology, where it is utilized in fermentation processes to produce lactic acid, a valuable compound used in food preservation and as a precursor for biodegradable plastics. This organism's ability to thrive in specific environments makes it a candidate for enhancing the efficiency of fermentation processes in the food industry, particularly in the production of fermented dairy products. In the realm of waste management, Limosilactobacillus fastidiosus can play a role in biodegradation of organic waste, contributing to the breakdown of complex organic materials into simpler compounds. This process not only helps in reducing waste volume but also aids in nutrient recycling, making it beneficial for composting and other waste treatment systems. Furthermore, its enzymatic activity is of interest in pharmaceutical development, where it may be involved in the production of specific enzymes that can be harnessed for drug formulation or as probiotics to enhance gut health. The organism's metabolic pathways can be explored for the development of novel therapeutic agents, particularly in the context of gut microbiota modulation. Overall, Limosilactobacillus fastidiosus demonstrates a versatile profile that can be leveraged across multiple industries, particularly in biofuel production, where its fermentation capabilities can be adapted to convert biomass into bioethanol, contributing to sustainable energy solutions.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4	openai/gpt-4	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	openai/gpt-4o	openai/gpt-4o	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	anaerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	true	false	false	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	gamma	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus	bacillus	coccus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus

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