Mycobacterium celatum

General Information

Mycobacterium celatum is a fascinating microorganism within the genus Mycobacterium, known for its clinical significance and unique genetic characteristics. This species is particularly interesting due to its ability to cause infections in humans, often presenting as pulmonary disease, which can be mistaken for tuberculosis due to similar clinical symptoms. One of the most notable features of M. celatum is its complex cell wall structure, which contributes to its resistance to many common antibiotics, making infections challenging to treat. This resistance is partly due to the presence of mycolic acids in its cell wall, a characteristic shared with other pathogenic mycobacteria. From a research perspective, M. celatum is valuable for studying antibiotic resistance mechanisms and the development of new therapeutic strategies. Its genome has been sequenced, providing insights into the genetic basis of its pathogenicity and resistance traits. Researchers are particularly interested in the genes involved in lipid metabolism and cell wall synthesis, as these are potential targets for novel drug development. Additionally, M. celatum has been used in studies exploring the immune response to mycobacterial infections. Understanding how the immune system interacts with this pathogen can help in designing better vaccines and immunotherapies for mycobacterial diseases. In summary, Mycobacterium celatum is a significant organism in the field of microbiology and infectious diseases, offering valuable insights into antibiotic resistance, pathogenesis, and immune response mechanisms.

Mycobacterium celatum is a species of the genus Mycobacterium that has garnered interest due to its unique ecological niche and potential implications in human health. This organism is notable for its ability to thrive in various environments, including soil and water, which highlights its adaptability and resilience. One of the most intriguing aspects of M. celatum is its association with opportunistic infections, particularly in immunocompromised individuals. This characteristic makes it a subject of study in the context of emerging infectious diseases and the challenges posed by antibiotic resistance. Furthermore, M. celatum has been identified in clinical samples, raising questions about its pathogenic potential and the mechanisms it employs to evade the host immune response. Research into this species could provide valuable insights into the broader Mycobacterium genus, which includes well-known pathogens such as Mycobacterium tuberculosis. The genetic and biochemical pathways of M. celatum are still being explored, and understanding these could lead to advancements in diagnostic methods and treatment strategies for mycobacterial infections. In addition to its medical relevance, M. celatum is also of interest in environmental microbiology. Its presence in diverse habitats suggests a role in nutrient cycling and ecosystem dynamics. Studying this organism can enhance our understanding of microbial diversity and the ecological roles of mycobacteria in various environments. Overall, Mycobacterium celatum represents a fascinating intersection of environmental science and medical research, making it a valuable subject for ongoing studies.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium celatum

NCBI ID

28045

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/742/165/GCF_002742165.1_ASM274216v1

File for sequence-based predictions:
GCF_002742165.1_ASM274216v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium celatum is a member of the Mycobacterium genus, which is known for its clinical significance in human health. It has been associated with pulmonary infections and is particularly notable for its role in opportunistic infections in immunocompromised patients. While it is not as widely recognized as other mycobacteria, such as Mycobacterium tuberculosis, its presence in clinical specimens has been documented, indicating its potential pathogenicity. One of the critical aspects of Mycobacterium celatum is its antimicrobial resistance. It has shown resistance to multiple antibiotics, which complicates treatment options for infections it may cause. This resistance is a significant concern in clinical settings, especially for patients with weakened immune systems, as it can lead to prolonged illness and increased healthcare costs. In terms of immune evasion strategies, Mycobacterium celatum can survive within macrophages, which are key components of the human immune system. This ability to persist in immune cells allows it to evade detection and destruction, contributing to its pathogenic potential. Although Mycobacterium celatum is not commonly associated with large outbreaks, its detection in clinical samples underscores the importance of monitoring for atypical mycobacterial infections, particularly in patients with underlying health conditions. Further research is needed to fully understand its clinical implications and potential role in human disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycobacterium celatum is a species of bacteria that is primarily associated with human environments, particularly in urban settings. This microorganism is often found in indoor environments such as homes, hospitals, and other buildings where it can thrive in the presence of organic materials and moisture. Its ecological niche is closely linked to areas with high levels of human activity, where it can exploit various substrates for growth. Notable Habitats: - Soil: _Mycobacterium celatum can be isolated from soil samples, indicating its ability to survive in terrestrial ecosystems. It plays a role in the decomposition of organic matter, contributing to nutrient cycling within the soil microbiome. - Water: This bacterium has also been detected in water sources, particularly in areas with poor sanitation or contaminated water supplies. Its presence in aquatic environments highlights its adaptability and potential role in biofilm formation on surfaces. Ecological Interactions: - Symbiosis: While specific symbiotic relationships for Mycobacterium celatum are not extensively documented, its interactions with other microorganisms in biofilms can enhance nutrient availability and promote microbial diversity in its habitats. - Pathogenicity: This species is known to be an opportunistic pathogen, particularly in immunocompromised individuals. Its ability to thrive in human-associated environments underscores its role in public health, as it can contribute to infections in susceptible populations. Overall, Mycobacterium celatum exemplifies a versatile microorganism that occupies various ecological niches within human-altered environments, showcasing its adaptability and significance in both ecological and health-related contexts.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium celatum has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycobacterium celatum may play a role in the fermentation of biomass, converting organic materials into biofuels through fermentation processes. This capability is particularly valuable in the development of sustainable energy sources, as it can help in the conversion of agricultural waste into usable fuel. Additionally, there is potential for Mycobacterium celatum in pharmaceutical development. Its unique metabolic pathways may lead to the discovery of novel compounds that could be utilized in drug formulation or as biocatalysts in various chemical reactions. The organism's ability to produce specific enzymes can be harnessed for enzyme production, which is crucial in the synthesis of pharmaceuticals and other valuable chemicals. Overall, Mycobacterium celatum presents a promising avenue for innovation in biotechnology, waste management, biofuel production, and pharmaceutical development, showcasing its versatility and importance in industrial applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	mistralai/mistral-7b-instruct	google/gemini-pro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-flash-1.5	google/gemini-flash-1.5	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	true	false	true	true	true	false	false	false	true	true	true	true	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	N/A	true	true	true	true	true	false	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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