Micromonospora humida

General Information

Micromonospora humida is a fascinating microorganism belonging to the genus Micromonospora, which is well-known for its prolific production of bioactive compounds. One of the most intriguing aspects of M. humida is its ability to produce a variety of secondary metabolites, many of which have significant pharmaceutical potential. These metabolites include antibiotics, antifungals, and antitumor agents, making M. humida a valuable resource in the search for new drugs and treatments. Another unique characteristic of M. humida is its ecological role. It is commonly found in soil environments, where it contributes to the decomposition of organic matter and the cycling of nutrients. This makes it an important player in maintaining soil health and fertility. From a research perspective, M. humida is particularly interesting due to its genetic and metabolic diversity. The genome of M. humida contains numerous gene clusters responsible for the biosynthesis of its diverse array of secondary metabolites. This genetic wealth provides a rich source of information for scientists studying natural product biosynthesis and microbial genetics. In summary, Micromonospora humida is a microorganism of significant interest due to its production of bioactive compounds, its ecological importance, and its genetic diversity. These characteristics make it a valuable subject for ongoing research in microbiology, biotechnology, and pharmaceutical sciences.

Micromonospora humida is a fascinating actinobacterium that has garnered attention due to its unique ecological niche and potential biotechnological applications. This microorganism is primarily found in soil and decaying organic matter, where it plays a crucial role in the degradation of complex organic compounds. Its ability to thrive in humid environments is reflected in its name, highlighting its adaptation to specific ecological conditions. One of the most interesting aspects of Micromonospora humida is its production of bioactive secondary metabolites. These compounds have been shown to exhibit antimicrobial properties, making this organism a valuable candidate for the discovery of new antibiotics. The potential for M. humida to produce novel compounds that can combat antibiotic-resistant bacteria is particularly significant in today's medical landscape. Additionally, Micromonospora humida is part of a larger group of actinobacteria known for their complex life cycles and filamentous growth forms. This characteristic not only contributes to its ecological role but also makes it a subject of interest in studies related to microbial ecology and evolution. The genetic and metabolic pathways involved in its secondary metabolite production are areas ripe for research, offering insights into microbial interactions and the biosynthesis of natural products. In summary, Micromonospora humida stands out due to its ecological significance, potential for antibiotic discovery, and its role in the broader context of actinobacterial research. Its unique adaptations and capabilities make it a promising organism for further study in microbiology and biotechnology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Micromonosporales

Family: Micromonosporaceae

Genus: Micromonospora

Species: Micromonospora humida

NCBI ID

2809018

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/016/901/255/GCA_016901255.1_ASM1690125v1

File for sequence-based predictions:
GCA_016901255.1_ASM1690125v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Micromonospora humida is a member of the actinobacteria group and is primarily known for its role in soil ecosystems. However, its clinical implications are becoming increasingly relevant. It has been isolated from various environmental sources, including soil and water, and has been associated with infections in humans, particularly in immunocompromised individuals. Clinical cases have reported its involvement in soft tissue infections and wound infections, highlighting its potential pathogenicity. One of the significant concerns regarding Micromonospora humida is its antimicrobial resistance. It has shown resistance to multiple classes of antibiotics, which complicates treatment options for infections it may cause. This resistance is particularly alarming in the context of rising antibiotic resistance globally, making it a focus of ongoing research. In terms of immune evasion, Micromonospora humida may employ various strategies to survive within the human host, although specific mechanisms are still under investigation. Its ability to thrive in diverse environments suggests a level of adaptability that could contribute to its pathogenic potential. While Micromonospora humida is not commonly associated with outbreaks, its presence in clinical settings raises awareness about the need for careful monitoring of environmental microorganisms that may pose a risk to human health. Further studies are necessary to fully understand its role in human health and disease associations.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Micromonospora humida is a species of actinobacteria commonly found in soil and freshwater environments. This microorganism thrives in moist habitats, particularly in areas with high organic matter content, such as decaying plant material and leaf litter. Its presence is often associated with the decomposition process, where it plays a crucial role in nutrient cycling by breaking down complex organic compounds into simpler forms that can be utilized by other organisms. In terms of ecological interactions, Micromonospora humida exhibits symbiotic relationships with various plants, aiding in the breakdown of organic matter and enhancing soil fertility. This bacterium is also known for its ability to produce bioactive compounds, which can inhibit the growth of certain pathogens, thus contributing to the overall health of the ecosystem. Furthermore, Micromonospora humida demonstrates remarkable environmental adaptability, allowing it to survive in varying conditions of moisture and nutrient availability. Its resilience makes it a key player in terrestrial biomes, particularly in temperate forests and wetlands, where it contributes to the maintenance of soil health and ecosystem stability.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Micromonospora humida has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is utilized for its ability to produce a range of bioactive compounds, including antibiotics. This makes it a valuable organism in the development of new pharmaceuticals, particularly in the fight against antibiotic-resistant bacteria. The fermentation process employed with Micromonospora humida allows for the extraction and purification of these compounds, which can lead to the development of novel therapeutic agents. In the realm of waste management, Micromonospora humida has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic materials. This property is beneficial in treating wastewater and organic waste, contributing to more sustainable waste management practices. The organism's enzymatic activity aids in the degradation of pollutants, making it a candidate for bioremediation efforts. Furthermore, Micromonospora humida has potential applications in biofuel production. Its metabolic pathways can be harnessed to convert biomass into biofuels through fermentation processes, thus contributing to renewable energy solutions. The efficiency of this microorganism in breaking down lignocellulosic materials can enhance the yield of biofuels, making it an important player in the transition to sustainable energy sources. Overall, Micromonospora humida stands out as a versatile microorganism with applications spanning pharmaceutical development, waste management, and biofuel production, showcasing its importance in modern industrial biotechnology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	mistralai/mistral-7b-instruct	google/gemini-pro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	false	true	true	true	true	true	false	true	true	true	true	true	true	false	false	true	true	false	false	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	true	true	true	false	true	true	true	false	true	true	false	false	true	true	true	true	false	false	false	false	true	true	true	true
Host association	N/A	false	false	true	false	true	false	false	true	false	true	true	false	false	false	false	false	false	false	false	false	false	true	true	false	false
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus

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