Bacteroides ovatus

General Information

Bacteroides ovatus is a fascinating microorganism primarily found in the human gut microbiota. This bacterium is part of the Bacteroidetes phylum, which plays a crucial role in the digestion of complex carbohydrates. One of the most noteworthy characteristics of B. ovatus is its ability to break down polysaccharides, including those that are otherwise indigestible by human enzymes. This capability is due to its extensive repertoire of carbohydrate-active enzymes (CAZymes), which enable it to degrade a wide variety of plant-derived and host-derived glycans. From a research perspective, B. ovatus is particularly valuable for its potential applications in probiotic therapies and gut health. Its role in the gut ecosystem includes not only aiding in digestion but also contributing to the maintenance of gut barrier integrity and modulation of the immune system. Studies have shown that B. ovatus can produce short-chain fatty acids (SCFAs) like butyrate, which are beneficial for colon health and have anti-inflammatory properties. Moreover, B. ovatus has been studied for its interactions with other gut microbes. It is known to engage in syntrophic relationships, where it cooperates with other bacteria to enhance the breakdown of complex substrates. This cooperative behavior is essential for maintaining a balanced and functional gut microbiome. In summary, Bacteroides ovatus is a key player in the human gut microbiome with significant implications for digestive health, immune modulation, and microbial ecology. Its ability to degrade complex carbohydrates and produce beneficial metabolites makes it a subject of ongoing research with potential therapeutic applications.

Bacteroides ovatus is a notable member of the human gut microbiota, playing a crucial role in the digestion of complex carbohydrates. This anaerobic bacterium is particularly interesting due to its ability to degrade polysaccharides, which are otherwise indigestible by human enzymes. This characteristic makes Bacteroides ovatus valuable in the context of gut health and nutrition, as it contributes to the fermentation process, producing short-chain fatty acids (SCFAs) that are beneficial for colonic health. Underlining its significance in research, Bacteroides ovatus has been studied for its potential role in modulating the immune system and influencing metabolic processes. The organism's ability to interact with the host's immune response highlights its potential implications in understanding inflammatory bowel diseases and other gastrointestinal disorders. Furthermore, Bacteroides ovatus is of interest in the field of probiotics and prebiotics, as its metabolic byproducts can enhance the growth of beneficial gut bacteria. This makes it a candidate for further exploration in developing dietary supplements aimed at improving gut microbiome diversity and overall health. In summary, Bacteroides ovatus stands out not only for its digestive capabilities but also for its broader implications in health and disease, making it a valuable subject for ongoing microbiological and clinical research.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacteroidota

Class: Bacteroidia

Order: Bacteroidales

Family: Bacteroidaceae

Genus: Bacteroides

Species: Bacteroides ovatus

NCBI ID

28116

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/314/995/GCF_001314995.1_ASM131499v1

File for sequence-based predictions:
GCF_001314995.1_ASM131499v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Bacteroides ovatus is a member of the human gut microbiota and plays a significant role in human health and disease associations. It is known for its ability to break down complex carbohydrates, contributing to the fermentation process in the gut and producing short-chain fatty acids, which are beneficial for intestinal health and may have anti-inflammatory properties. However, Bacteroides ovatus can also be associated with opportunistic infections, particularly in immunocompromised individuals or those with disrupted gut microbiota. In such cases, it may lead to bacteremia or abscess formation. Furthermore, there is growing concern regarding the antimicrobial resistance of Bacteroides ovatus. This organism has been documented to possess resistance mechanisms against several classes of antibiotics, including beta-lactams and aminoglycosides, which complicates treatment options for infections it may cause. The presence of resistance genes in this species highlights the need for careful antibiotic stewardship and monitoring in clinical settings. In terms of immune evasion, Bacteroides ovatus has developed strategies to survive in the gut environment, including the production of polysaccharide capsules that can inhibit phagocytosis by immune cells. This ability to evade the immune response can contribute to its persistence in the gut and its potential to cause disease under certain conditions. Additionally, there is ongoing research into the potential of Bacteroides ovatus as a probiotic. Some studies suggest that it may help restore gut microbiota balance and improve gut health, particularly after antibiotic treatment. However, more research is needed to fully understand its benefits and applications in therapeutics and vaccines.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Bacteroides ovatus is a prominent member of the human gut microbiota, thriving primarily in the gastrointestinal tract of humans. This microorganism plays a crucial role in the digestion of complex carbohydrates, particularly those derived from dietary fibers. Its ability to break down these compounds into short-chain fatty acids (SCFAs) is essential for maintaining gut health and providing energy to colon cells. Ecological Niches associated with Bacteroides ovatus include: - Fermentative environments: This organism is adept at fermenting polysaccharides, contributing to the overall metabolic processes within the gut. - Symbiotic relationships: Bacteroides ovatus often engages in mutualistic interactions with other gut microbiota, enhancing nutrient availability and promoting a balanced microbial community. In addition to its role in digestion, Bacteroides ovatus is involved in the modulation of the host's immune response, helping to maintain a healthy gut barrier and preventing the overgrowth of pathogenic bacteria. Its presence is often associated with a healthy microbiome, and alterations in its abundance can be linked to various gastrointestinal disorders. Overall, Bacteroides ovatus exemplifies the intricate relationships within the gut biome, highlighting its importance in human health and disease.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Bacteroides ovatus has shown significant potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to degrade complex carbohydrates, making it a valuable asset in biodegradation processes. Its enzymatic activity allows it to break down polysaccharides, which can be harnessed in the production of biofuels through fermentation processes. In the realm of biofuel production, Bacteroides ovatus can be utilized to convert lignocellulosic biomass into fermentable sugars, which can then be fermented by other microorganisms to produce ethanol or other biofuels. This process not only contributes to renewable energy sources but also aids in reducing waste from agricultural residues. Furthermore, in waste management, Bacteroides ovatus plays a crucial role in the breakdown of organic matter in anaerobic digestion systems, enhancing the efficiency of waste treatment processes. By facilitating the decomposition of organic waste, it helps in the production of biogas, which can be used as a sustainable energy source. In pharmaceutical development, the metabolic products of Bacteroides ovatus have been studied for their potential health benefits, including their role in gut health and their ability to produce short-chain fatty acids, which are important for maintaining intestinal homeostasis. This highlights the organism's relevance in the development of probiotics and other health-related products. Overall, Bacteroides ovatus demonstrates a multifaceted utility across various industries, particularly in processes that involve fermentation, biodegradation, and enzyme production, making it a significant microorganism in the pursuit of sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain negative	gram stain negative ✓	N/A	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	anaerobic	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	true	true	true	true	true	false	false	false	true	false	false	false	false	true	true	false	false	true	true	true	true	true	true	false	false	true	true
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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