Bacillus sanguinis

General Information

Bacillus sanguinis is a fascinating microorganism that has garnered attention due to its unique characteristics and potential applications in various fields. One of the most intriguing aspects of B. sanguinis is its ability to produce a distinctive red pigment, which is not only visually striking but also of interest for its potential use in natural dye production and as a biological marker in research. Additionally, B. sanguinis has been studied for its potential antimicrobial properties. The compounds produced by this bacterium have shown promise in inhibiting the growth of certain pathogenic microorganisms, making it a candidate for the development of new antibiotics or antimicrobial agents. This is particularly important in the context of rising antibiotic resistance, where novel solutions are urgently needed. From a biotechnological perspective, B. sanguinis is also valuable due to its ability to produce enzymes that can be harnessed for industrial applications. These enzymes may be used in processes such as bioremediation, where they help break down environmental pollutants, or in the production of biofuels, contributing to more sustainable energy solutions. In summary, Bacillus sanguinis stands out due to its distinctive red pigment production, potential antimicrobial properties, and valuable enzymatic activities. These characteristics make it a subject of ongoing research with promising applications in medicine, industry, and environmental science.

Bacillus sanguinis is a fascinating bacterium that has garnered attention due to its unique ecological niche and potential applications in biotechnology. This species is primarily known for its ability to thrive in various environments, including soil and water, which makes it an important player in nutrient cycling and soil health. One of the most interesting aspects of Bacillus sanguinis is its capacity to produce a range of bioactive compounds, including antimicrobial peptides and enzymes, which can be valuable in agricultural and pharmaceutical applications. Underlining its significance, Bacillus sanguinis has been studied for its role in biocontrol, where it can suppress plant pathogens, thereby promoting healthier crop yields. This characteristic positions it as a potential candidate for sustainable agriculture practices, reducing the reliance on chemical pesticides. Moreover, the organism's ability to form endospores allows it to survive in harsh conditions, making it a resilient species that can be utilized in various industrial processes. The genetic and metabolic pathways of Bacillus sanguinis are also of great interest to researchers, as they may provide insights into the development of novel biotechnological applications, including the production of enzymes for bioremediation and waste management. In summary, Bacillus sanguinis stands out not only for its ecological importance but also for its potential contributions to biotechnology and sustainable practices, making it a valuable subject of study in microbiology and environmental science.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Bacilli

Order: Bacillales

Family: Bacillaceae

Genus: Bacillus

Species: Bacillus sanguinis

NCBI ID

2817476

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/018/332/475/GCA_018332475.1_ASM1833247v1

File for sequence-based predictions:
GCA_018332475.1_ASM1833247v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Bacillus sanguinis is a Gram-positive, rod-shaped organism that is part of the normal flora of the human mouth and gastrointestinal tract. It has been associated with various clinical implications, particularly in the context of infections and disease associations. Bacillus sanguinis is known to be a potential opportunistic pathogen, especially in immunocompromised individuals, where it can lead to bacteremia and endocarditis. Its role in these conditions underscores the importance of maintaining a healthy oral microbiome, as disruptions can lead to increased risk of systemic infections. In terms of pathogenicity, Bacillus sanguinis has been shown to possess certain virulence factors that may contribute to its ability to evade the immune response. These factors include the production of biofilms, which can protect the bacteria from phagocytosis and antibiotic treatment. Furthermore, there is evidence suggesting that this organism may exhibit antimicrobial resistance, complicating treatment options for infections it may cause. Interestingly, Bacillus sanguinis has also been studied for its potential medical applications. Some strains are being explored for use as probiotics due to their ability to produce beneficial metabolites and modulate the gut microbiota. This highlights the dual nature of Bacillus sanguinis as both a potential pathogen and a beneficial organism, depending on the context of its presence in the human body. Overall, while Bacillus sanguinis is primarily recognized as a commensal organism, its potential to cause infections and its role in immune evasion strategies warrant further investigation, particularly in clinical settings where patients may be at increased risk.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Bacillus sanguinis is a gram-positive bacterium commonly found in various habitats associated with soil and the human oral cavity. This microorganism thrives in terrestrial ecosystems, particularly in nutrient-rich soils where it plays a crucial role in the decomposition of organic matter. Its ability to form endospores allows it to withstand extreme environmental conditions, making it resilient in arid and nutrient-poor environments as well. In the context of the human microbiome, Bacillus sanguinis is often present in the oral cavity, where it contributes to the complex microbial community. It is known to engage in symbiotic relationships with other oral bacteria, aiding in the maintenance of oral health by outcompeting pathogenic microorganisms. This bacterium can also produce antimicrobial compounds, which further enhances its role in oral ecology. Additionally, Bacillus sanguinis has been studied for its potential in bioremediation, where it can help in the breakdown of pollutants in contaminated soils. Its adaptability to various environmental conditions and its interactions with other microorganisms underscore its importance in both natural and human-associated ecosystems.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Bacillus sanguinis has shown significant potential in various industrial applications. One of the primary areas is biotechnology, where Bacillus sanguinis is utilized for its ability to produce enzymes that can be harnessed in biocatalysis processes. These enzymes are particularly valuable in the food industry for applications such as fermentation, where they can enhance the flavor and texture of products like cheese and soy sauce. In the realm of waste management, Bacillus sanguinis has been studied for its capacity to degrade organic pollutants. This makes it a candidate for use in bioremediation efforts, where it can help in the breakdown of hazardous substances in contaminated environments, thus contributing to environmental cleanup initiatives. Furthermore, the organism has potential in biofuel production. Its metabolic pathways can be exploited to convert biomass into biofuels through fermentation processes, which can lead to the production of bioethanol or biobutanol, providing a renewable energy source. In pharmaceutical development, Bacillus sanguinis is being explored for its antimicrobial properties, which could lead to the development of new antibiotics or other therapeutic agents. The organism's ability to produce secondary metabolites is of particular interest in this field. Overall, Bacillus sanguinis demonstrates versatility across multiple industries, making it a valuable microorganism for future research and application in sustainable practices and innovative solutions.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro-1.5	google/gemini-pro	google/gemini-flash-1.5	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4	openai/gpt-4	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	google/gemma-7b-it	openchat/openchat-7b	openchat/openchat-7b
Motility	FALSE	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Biosafety level	N/A	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1
Health association	N/A	true	true	true	true	true	true	false	true	true	false	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	false ✗	true ✓	true ✓	false ✗	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	alpha	gamma	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	beta	beta	gamma	gamma	alpha	alpha	beta	beta	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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