Streptomyces coelicoflavus

General Information

Streptomyces coelicoflavus is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. coelicoflavus is its ability to produce a wide array of antibiotics and bioactive compounds. This makes it a valuable organism in the field of biotechnology and pharmaceutical research. Streptomyces species are known for their complex life cycle, which includes the formation of a mycelium and spore chains, contributing to their unique colony morphology. S. coelicoflavus is no exception, exhibiting a filamentous structure that is typical of the genus. The production of pigments is another interesting feature of S. coelicoflavus. These pigments can vary in color and are often used as indicators of different metabolic states or environmental conditions. The ability to produce such pigments not only has potential applications in industrial processes but also provides insights into the organism's metabolic pathways. From a genetic perspective, S. coelicoflavus has a large and complex genome, which encodes for numerous biosynthetic gene clusters. These clusters are responsible for the synthesis of its diverse secondary metabolites. The study of these gene clusters can lead to the discovery of new drugs and therapeutic agents, making S. coelicoflavus a significant subject of research in natural product chemistry. In summary, Streptomyces coelicoflavus stands out due to its prolific production of antibiotics, complex life cycle, pigment production, and rich genetic makeup. These characteristics not only make it an organism of great scientific interest but also a valuable resource for the development of new pharmaceuticals and biotechnological applications.

Streptomyces coelicoflavus is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, including antibiotics and antifungal agents. This organism is particularly interesting due to its extensive secondary metabolite production, which has made it a subject of interest in pharmaceutical research. The unique metabolic pathways of S. coelicoflavus allow it to synthesize compounds that can inhibit the growth of various pathogens, making it a valuable resource in the search for new therapeutic agents. One of the standout features of S. coelicoflavus is its ability to produce coelichelin, a siderophore that plays a crucial role in iron acquisition. This characteristic not only highlights the organism's adaptability to nutrient-limited environments but also underscores its potential applications in bioremediation and agriculture, where iron availability can be a limiting factor for plant growth. Additionally, S. coelicoflavus has been studied for its genomic characteristics, which reveal insights into the genetic basis of its secondary metabolite biosynthesis. The sequencing of its genome has provided researchers with valuable information that can be leveraged to enhance the production of desired compounds through genetic engineering techniques. Overall, the unique biochemical capabilities and genetic insights of Streptomyces coelicoflavus make it a significant organism in the fields of microbiology, pharmacology, and biotechnology, offering promising avenues for the development of new drugs and agricultural solutions.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces coelicoflavus

NCBI ID

285562

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/036/101/175/GCF_036101175.1_ASM3610117v1

File for sequence-based predictions:
GCF_036101175.1_ASM3610117v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces coelicoflavus is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. This microorganism has been studied for its potential in antimicrobial resistance due to its ability to produce various secondary metabolites that can inhibit the growth of pathogenic bacteria. Notably, it has been associated with the production of antibiotics such as actinomycin and other compounds that may have therapeutic applications in treating infections caused by resistant strains of bacteria. In terms of human health, Streptomyces coelicoflavus is not typically recognized as a primary pathogen; however, its metabolites can influence the microbial balance in the human microbiome. The organism's role in probiotics is an area of interest, as certain strains of Streptomyces have been explored for their potential benefits in gut health and immune modulation. The pathogenicity of Streptomyces coelicoflavus is generally low, but its ability to produce bioactive compounds raises concerns regarding immune evasion strategies and the potential for opportunistic infections in immunocompromised individuals. Furthermore, the organism's genetic adaptability may contribute to the emergence of antimicrobial resistance in clinical settings, particularly in relation to its antibiotic production capabilities. Overall, while Streptomyces coelicoflavus is primarily recognized for its beneficial applications in medicine, its interactions with human health and disease, particularly in the context of antibiotic production and resistance mechanisms, warrant further investigation to fully understand its clinical implications.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces coelicoflavus is a species of filamentous bacteria that thrives primarily in soil ecosystems and is commonly associated with decaying organic matter. This microorganism plays a crucial role in the decomposition process, contributing to nutrient cycling and soil health. Its ability to degrade complex organic compounds makes it an essential player in the terrestrial biome, particularly in nutrient-rich environments where organic material is abundant. In addition to its role in decomposition, Streptomyces coelicoflavus is known for its production of various antibiotics and other bioactive compounds, which can inhibit the growth of competing microorganisms. This characteristic not only aids in its survival but also influences the microbial community structure within its habitat, showcasing its role in microbial interactions and competition. Furthermore, this organism exhibits remarkable environmental adaptability, allowing it to thrive in diverse conditions, from nutrient-poor soils to more enriched environments. Its filamentous growth form enables it to efficiently explore the soil matrix, enhancing its ability to access nutrients and water. Overall, Streptomyces coelicoflavus is a vital component of the soil biome, contributing to ecological balance through its roles in decomposition, nutrient cycling, and microbial competition.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces coelicoflavus is renowned for its significant contributions to various industrial applications. One of the primary areas of interest is in biotechnology, where S. coelicoflavus is utilized for its ability to produce a wide range of bioactive compounds, including antibiotics and enzymes. This organism is particularly noted for its role in fermentation, which is a critical process in the production of pharmaceuticals and agricultural products. In the realm of waste management, S. coelicoflavus has demonstrated capabilities in biodegradation, effectively breaking down complex organic materials and pollutants. This makes it a valuable asset in the treatment of contaminated soils and wastewater, contributing to environmental sustainability. Moreover, the potential of S. coelicoflavus in biofuel production is being explored, particularly in the conversion of biomass into biofuels through fermentation processes. The enzymes produced by this microorganism can facilitate the breakdown of lignocellulosic materials, enhancing the efficiency of biofuel generation. In pharmaceutical development, the secondary metabolites produced by S. coelicoflavus have been investigated for their therapeutic properties, leading to the discovery of new drugs. The organism's ability to produce unique compounds through enzyme production is of particular interest in the development of novel antibiotics and anticancer agents. Overall, Streptomyces coelicoflavus exemplifies the versatility of actinobacteria in various industrial sectors, showcasing its importance in biotechnology, waste management, biofuel production, and pharmaceutical development.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	google/gemini-pro	google/gemini-pro	openchat/openchat-7b	openchat/openchat-7b
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	true	false	false	true	true	true	false	true	false	false	false	false	true	true	true	true	true	true	true	true	false	true	true	true	true
Host association	FALSE	true ✗	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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