Actinomadura parmotrematis

General Information

Actinomadura parmotrematis is a fascinating microorganism belonging to the genus Actinomadura. This species was first isolated from the lichen Parmotrema in Thailand, which highlights its unique ecological niche. One of the most interesting aspects of A. parmotrematis is its potential for producing bioactive compounds. Members of the genus Actinomadura are well-known for their ability to synthesize a variety of secondary metabolites, including antibiotics, antifungals, and anticancer agents. This makes A. parmotrematis a valuable subject for biotechnological and pharmaceutical research. Another notable feature of A. parmotrematis is its complex life cycle, which includes the formation of branching hyphae and the production of spores. This morphological complexity is not only intriguing from a biological standpoint but also suggests potential applications in industrial microbiology, where filamentous bacteria are often exploited for the production of enzymes and other bioproducts. Furthermore, the isolation of A. parmotrematis from a lichen environment suggests that it may have unique symbiotic relationships or interactions with its host. This could provide insights into microbial ecology and the evolution of symbiotic partnerships. The study of such interactions could lead to the discovery of novel compounds or mechanisms that could be harnessed for various applications. In summary, Actinomadura parmotrematis is a microorganism of significant interest due to its potential for producing bioactive compounds, its complex life cycle, and its unique ecological niche. These characteristics make it a valuable organism for further research in multiple scientific fields.

Actinomadura parmotrematis is a fascinating actinobacterial species known for its unique ecological niche and potential biotechnological applications. This microorganism is primarily isolated from soil environments, particularly those rich in organic matter, which highlights its role in nutrient cycling and soil health. One of the most interesting aspects of A. parmotrematis is its ability to produce a variety of bioactive compounds, including antibiotics and enzymes, making it a valuable organism for pharmaceutical research and development. The genus Actinomadura is recognized for its filamentous growth form, which is characteristic of many actinobacteria. This filamentous structure not only aids in nutrient absorption but also contributes to its competitive advantage in diverse habitats. The secondary metabolites produced by A. parmotrematis have shown promise in antimicrobial activity, which is particularly relevant in the context of rising antibiotic resistance. Furthermore, A. parmotrematis has been studied for its potential in bioremediation processes, as it can degrade various environmental pollutants. This capability underscores its importance in environmental microbiology and the search for sustainable solutions to pollution. Overall, Actinomadura parmotrematis stands out as a significant organism in both ecological and applied microbiological research, offering insights into microbial diversity and the potential for novel biotechnological innovations.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Streptosporangiales

Family: Thermomonosporaceae

Genus: Actinomadura

Species: Actinomadura parmotrematis

NCBI ID

2864039

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/019/458/805/GCA_019458805.1_ASM1945880v1

File for sequence-based predictions:
GCA_019458805.1_ASM1945880v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Actinomadura parmotrematis is a member of the Actinomycetes group, which is known for its complex life cycle and ability to produce a variety of bioactive compounds. While specific clinical implications of Actinomadura parmotrematis are not extensively documented, its relatives within the Actinomadura genus have been associated with opportunistic infections in immunocompromised patients. These infections can manifest as soft tissue infections, pulmonary infections, and systemic infections, particularly in individuals with underlying health conditions. One notable aspect of Actinomadura parmotrematis is its potential for antimicrobial resistance, which is a significant concern in clinical settings. The genus is known to produce various enzymes that can inactivate antibiotics, leading to challenges in treatment. This resistance can complicate the management of infections, necessitating the use of alternative therapeutic strategies. In terms of immune evasion strategies, members of the Actinomadura genus may employ mechanisms such as biofilm formation, which protects them from host immune responses and enhances their survival in hostile environments. While Actinomadura parmotrematis itself has not been directly linked to any major outbreaks, its relatives have been implicated in sporadic cases of infection, highlighting the need for vigilance in clinical microbiology. Further research is necessary to fully elucidate the clinical significance of Actinomadura parmotrematis and its potential role in human health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Actinomadura parmotrematis is a species of actinobacteria that is primarily associated with soil ecosystems and marine environments. This microorganism thrives in nutrient-rich substrates, often found in decaying organic matter, where it plays a crucial role in the decomposition process. Its ability to degrade complex organic compounds makes it an important player in nutrient cycling within these biomes. Soil Ecosystems: In terrestrial habitats, Actinomadura parmotrematis is commonly found in agricultural soils and forest floors. Here, it contributes to the breakdown of plant materials, enhancing soil fertility and promoting the growth of other organisms. The presence of this bacterium can improve soil structure and nutrient availability, which is vital for plant health. Marine Environments: This microorganism has also been isolated from marine sediments, where it participates in the degradation of organic matter that settles on the ocean floor. In these environments, Actinomadura parmotrematis interacts with other microbial communities, contributing to the overall health of the marine ecosystem. Its metabolic activities can influence the biogeochemical cycles of carbon and nitrogen, highlighting its role in maintaining ecological balance. In both environments, Actinomadura parmotrematis may engage in symbiotic relationships with plants and other microorganisms, enhancing nutrient uptake and promoting biodiversity. Its adaptability to various environmental conditions underscores its significance in both terrestrial and aquatic biomes, making it a key organism in ecological studies and applications in biotechnology.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Actinomadura parmotrematis has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is utilized for its ability to produce a range of bioactive compounds, including antibiotics and enzymes. This organism is particularly valuable in the fermentation process, where it can be harnessed to synthesize secondary metabolites that have pharmaceutical relevance. In the realm of waste management, Actinomadura parmotrematis has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic materials. This makes it a candidate for use in bioremediation efforts, where it can help in the detoxification of contaminated environments, such as soil and water, by degrading pollutants. Furthermore, the organism's enzymatic activity is of interest in biofuel production. It can be involved in the conversion of biomass into fermentable sugars, which can then be transformed into biofuels. This process not only contributes to renewable energy sources but also aids in reducing waste by utilizing agricultural residues. In summary, Actinomadura parmotrematis is a versatile microorganism with applications spanning pharmaceutical development, biotechnology, waste management, and biofuel production, showcasing its importance in sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	N/A	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	false	true	true	true	false	true	false	true	true	true	true	false	false	true	true	false	false	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	false	false	false	true	true	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	true	true	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	false	true	true	true	true	false	true	false	false	false	false	false	true	true	true	true	false	false	true	true	true	true	false	false	false	false
Host association	N/A	false	false	true	false	true	true	false	true	false	false	false	false	false	false	false	false	false	false	false	true	true	true	true	false	false	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Hemolysis	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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