Paeniclostridium ghonii

General Information

Paeniclostridium ghonii is a fascinating microorganism that has garnered attention due to its unique metabolic capabilities and potential applications in biotechnology. This bacterium is part of the Paeniclostridium genus, which is known for its diverse metabolic pathways and ability to thrive in various environments. One of the most intriguing aspects of P. ghonii is its ability to produce a wide range of enzymes that can break down complex organic materials. This makes it a valuable candidate for industrial applications, particularly in the fields of waste management and biofuel production. The enzymes produced by P. ghonii can degrade lignocellulosic biomass, which is a major component of plant material and a significant source of renewable energy. Additionally, P. ghonii has shown potential in the field of bioremediation. Its metabolic versatility allows it to degrade various environmental pollutants, including hydrocarbons and heavy metals. This capability is particularly important for cleaning up contaminated sites and reducing the environmental impact of industrial activities. From a research perspective, P. ghonii is also interesting due to its genomic features. The genome of this bacterium contains several unique genes that are not found in closely related species, suggesting that it has evolved distinct metabolic pathways. Studying these genes can provide insights into microbial evolution and the development of novel biochemical processes. In summary, Paeniclostridium ghonii is a microorganism of significant interest due to its metabolic diversity, potential industrial applications, and unique genomic characteristics. Its ability to degrade complex organic materials and environmental pollutants makes it a valuable subject for ongoing research and biotechnological innovation.

Paeniclostridium ghonii is a fascinating anaerobic bacterium that belongs to the genus Paeniclostridium. This organism is particularly interesting due to its unique metabolic capabilities and its potential applications in biotechnology and medicine. One of the most notable characteristics of P. ghonii is its ability to degrade complex carbohydrates, which positions it as a valuable player in the field of bioremediation and waste management. This capability allows it to break down polysaccharides into simpler sugars, which can then be utilized by other microorganisms in various ecological processes. Furthermore, P. ghonii has been studied for its potential role in the production of biofuels. The fermentation pathways utilized by this bacterium can lead to the generation of short-chain fatty acids and other valuable metabolites, making it a candidate for sustainable energy production. Researchers are particularly interested in how the metabolic pathways of P. ghonii can be harnessed to improve the efficiency of biofuel production processes. In addition to its biotechnological applications, Paeniclostridium ghonii has also garnered attention in the field of microbiome research. Its presence in various environments, including the human gut, suggests it may play a role in maintaining gut health and influencing host metabolism. Understanding the interactions between P. ghonii and other members of the microbiome could provide insights into its potential health benefits or implications in disease states. Overall, the unique metabolic properties and ecological significance of Paeniclostridium ghonii make it a subject of ongoing research, with promising implications for both environmental sustainability and human health.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Clostridia

Order: Peptostreptococcales

Family: Peptostreptococcaceae

Genus: Paraclostridium

Species: Paraclostridium ghonii

NCBI ID

29358

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/023/653/455/GCA_023653455.1_ASM2365345v1

File for sequence-based predictions:
GCA_023653455.1_ASM2365345v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Paeniclostridium ghonii is a member of the Clostridia class and has been associated with various clinical implications. It is primarily known for its role in infections related to the gastrointestinal tract. This microorganism can be involved in diarrheal diseases, particularly in immunocompromised individuals, where it may contribute to severe gastroenteritis and colitis. Its pathogenicity is attributed to the production of toxins that can disrupt normal gut flora and lead to inflammation. In terms of antimicrobial resistance, Paeniclostridium ghonii has shown resistance to several commonly used antibiotics, which complicates treatment options for infections it may cause. This resistance is often linked to the presence of specific resistance genes that can be transferred between bacterial species, raising concerns about the potential for multidrug-resistant infections. The organism's interaction with the human body involves evasion of the immune response, allowing it to persist in the gut environment. It may employ various strategies, such as biofilm formation and the secretion of virulence factors, to avoid detection and clearance by the host's immune system. While Paeniclostridium ghonii is not widely recognized in clinical settings compared to other Clostridia species, its potential role in outbreaks of gastrointestinal illness highlights the need for further research into its epidemiology and pathogenic mechanisms. Understanding its clinical relevance is crucial for developing effective treatment and prevention strategies.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Paeniclostridium ghonii is a bacterium that is primarily associated with anaerobic environments, particularly within the gastrointestinal tracts of various animals, including humans. This microorganism thrives in conditions where oxygen is limited, making it a key player in the gut microbiome. Habitat and Ecological Niche: In the gut, _Paeniclostridium ghonii contributes to the breakdown of complex carbohydrates and proteins, facilitating nutrient absorption and energy production for the host. Its presence is crucial for maintaining a balanced microbial community, which is essential for digestive health. The bacterium is known to engage in fermentation processes, producing short-chain fatty acids that serve as an energy source for intestinal cells and play a role in regulating immune responses. Interactions and Roles: This microorganism often exists in a symbiotic relationship with other gut flora, helping to suppress pathogenic bacteria and contributing to the overall stability of the gut ecosystem. By producing metabolites that inhibit harmful microbes, Paeniclostridium ghonii plays a significant role in maintaining homeostasis within the gut environment. Additionally, its ability to adapt to varying conditions within the gut, such as changes in pH and nutrient availability, underscores its ecological significance. Overall, Paeniclostridium ghonii exemplifies the intricate relationships within the gut biome, highlighting the importance of anaerobic bacteria in health and disease.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Paeniclostridium ghonii has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and biofuel production. This anaerobic bacterium is known for its ability to perform fermentation, which can be harnessed for the production of valuable metabolites such as organic acids and solvents. In the realm of biotechnology, Paeniclostridium ghonii can be utilized in the production of bioplastics and other biodegradable materials through its metabolic pathways. Its enzymatic activity is also significant, as it can produce enzymes that facilitate the breakdown of complex organic compounds, making it a candidate for biodegradation processes in waste management. In terms of biofuel production, this microorganism can be involved in the conversion of biomass into biofuels through fermentation processes, where it helps in the breakdown of lignocellulosic materials into fermentable sugars, which can then be converted into ethanol or other biofuels. Furthermore, the potential for Paeniclostridium ghonii in pharmaceutical development is noteworthy, as its metabolic products may have applications in drug formulation or as precursors for pharmaceutical compounds. Overall, the diverse capabilities of Paeniclostridium ghonii make it a valuable organism in several industrial sectors, particularly where sustainable practices and innovative bioprocesses are sought.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	TRUE	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗
Gram staining	gram stain positive	N/A	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗
Aerophilicity	anaerobic	anaerobic ✓	anaerobic ✓	aerotolerant ✗	anaerobic ✓	N/A	N/A	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	true	false	false	true	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	true	true	true	true	false	false
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	false	false	false	false	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗
Health association	N/A	true	true	false	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Hemolysis	N/A	beta	beta	N/A	N/A	alpha	alpha	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	coccus

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