Anaerobutyricum hallii

General Information

Anaerobutyricum hallii is a fascinating microorganism that has garnered significant interest in the scientific community due to its unique metabolic capabilities and potential health benefits. This bacterium is part of the human gut microbiota and plays a crucial role in maintaining gut health. One of the most notable features of A. hallii is its ability to produce butyrate, a short-chain fatty acid that serves as an important energy source for colonocytes and has anti-inflammatory properties. Butyrate production by A. hallii is linked to various health benefits, including improved gut barrier function, modulation of the immune system, and potential protective effects against colorectal cancer. Another intriguing aspect of A. hallii is its involvement in the fermentation of dietary fibers. This bacterium can break down complex carbohydrates that are otherwise indigestible by the human host, converting them into beneficial metabolites. This capability highlights the importance of A. hallii in the context of a high-fiber diet and its contribution to overall gut health. From a research perspective, A. hallii is valuable for its potential applications in probiotic development. Its ability to produce butyrate and other beneficial compounds makes it a promising candidate for therapeutic interventions aimed at treating or preventing gastrointestinal disorders. Additionally, understanding the interactions between A. hallii and other members of the gut microbiota can provide insights into the complex dynamics of microbial communities and their impact on human health. In summary, Anaerobutyricum hallii is a key player in the gut ecosystem with significant implications for health and disease. Its butyrate-producing capability, role in fiber fermentation, and potential as a probiotic make it a microorganism of great interest in both basic and applied microbiological research.

Anaerobutyricum hallii is a fascinating anaerobic bacterium that plays a significant role in the human gut microbiome. This organism is particularly interesting due to its ability to ferment dietary fibers and produce short-chain fatty acids (SCFAs), such as butyrate, which are crucial for maintaining gut health and regulating immune responses. Butyrate is known for its anti-inflammatory properties and its role in providing energy to colonocytes, the cells lining the colon. One of the unique aspects of A. hallii is its capacity to thrive in the complex and competitive environment of the gut, where it contributes to the overall metabolic activity of the microbiome. This bacterium has been linked to various health benefits, including improved gut barrier function and potential protective effects against inflammatory bowel diseases (IBD). Furthermore, A. hallii has garnered attention in research for its potential implications in obesity and metabolic syndrome. Studies suggest that a higher abundance of this species may correlate with a healthier metabolic profile, making it a valuable target for therapeutic interventions aimed at modulating gut microbiota composition. In summary, Anaerobutyricum hallii stands out not only for its metabolic capabilities but also for its contributions to human health, particularly in the context of gut health and metabolic diseases. Its role in producing beneficial metabolites like butyrate underscores its importance in both basic and applied microbiological research.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Clostridia

Order: Lachnospirales

Family: Lachnospiraceae

Genus: Anaerobutyricum

Species: Anaerobutyricum hallii

NCBI ID

39488

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/036/419/155/GCF_036419155.1_ASM3641915v1

File for sequence-based predictions:
GCF_036419155.1_ASM3641915v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Anaerobutyricum hallii is a Gram-positive, anaerobic bacterium that plays a significant role in human gut microbiota. It is known for its ability to produce butyrate, a short-chain fatty acid that is crucial for intestinal health and has anti-inflammatory properties. Butyrate serves as an energy source for colonocytes and is involved in maintaining the integrity of the gut barrier, thus contributing to immune response and overall gut health. In terms of disease associations, A. hallii has been linked to various gastrointestinal disorders, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). A decrease in the abundance of this bacterium has been observed in patients with these conditions, suggesting its potential role in dysbiosis and disease pathogenesis. Furthermore, A. hallii has garnered attention for its potential as a probiotic. Its ability to produce butyrate may help in the management of metabolic disorders such as obesity and type 2 diabetes, as butyrate is known to improve insulin sensitivity and reduce inflammation. Regarding antimicrobial resistance, there is currently limited data on the resistance mechanisms of A. hallii. However, the overall trend of increasing resistance among gut microbiota highlights the need for ongoing surveillance and research. In summary, Anaerobutyricum hallii is a key player in maintaining gut health, with implications for disease prevention and potential therapeutic applications in managing gastrointestinal and metabolic disorders.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Anaerobutyricum hallii is a notable member of the gut microbiota, primarily found in the human gastrointestinal tract. This microorganism thrives in anaerobic environments, where oxygen levels are low or absent, making it well-adapted to the conditions of the intestines. Its ecological niche is characterized by its ability to ferment dietary fibers and produce short-chain fatty acids, particularly butyrate, which is crucial for maintaining gut health and providing energy to colonocytes (the cells lining the colon). In the context of its habitat, Anaerobutyricum hallii plays a significant role in the gut ecosystem by contributing to the overall microbial diversity and stability. It engages in symbiotic relationships with other gut bacteria, facilitating the breakdown of complex carbohydrates and enhancing nutrient absorption. This interaction is vital for the host's health, as it helps regulate immune responses and maintain the integrity of the gut barrier. Furthermore, Anaerobutyricum hallii is associated with fermented foods and can be found in the intestinal microbiomes of individuals consuming a high-fiber diet. Its presence is often linked to positive health outcomes, including reduced inflammation and improved metabolic health. Overall, this microorganism exemplifies the intricate connections within the gut microbiome and its impact on host physiology.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Anaerobutyricum hallii has shown significant potential in various industrial applications, particularly in the fields of biotechnology, waste management, and biofuel production. This anaerobic bacterium is known for its ability to ferment a variety of substrates, making it a valuable player in fermentation processes. It can effectively convert complex carbohydrates into short-chain fatty acids, which are important for energy production and can be utilized in the food industry as well as in animal feed formulations. In the realm of waste management, Anaerobutyricum hallii contributes to the biodegradation of organic waste, particularly in anaerobic digestion systems. This process not only helps in reducing waste volume but also facilitates the production of biogas, a renewable energy source. The bacterium's metabolic pathways are crucial for the breakdown of lignocellulosic materials, enhancing the efficiency of waste treatment facilities. Furthermore, in biofuel production, Anaerobutyricum hallii plays a role in the conversion of biomass into biofuels through fermentation processes. By utilizing agricultural residues and other organic materials, it aids in the production of bioethanol and other biofuels, contributing to sustainable energy solutions. In the pharmaceutical development sector, the metabolic products of Anaerobutyricum hallii have been studied for their potential health benefits, including anti-inflammatory properties. This opens avenues for the development of new therapeutic agents derived from its fermentation products. Overall, Anaerobutyricum hallii exemplifies the versatility of microorganisms in industrial applications, particularly through its roles in fermentation, biodegradation, and biofuel production, making it a significant organism in the pursuit of sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	openchat/openchat-7b	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	mistralai/mistral-7b-instruct	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/gemini-pro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	gram stain negative ✗	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	anaerobic	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Biofilm formation	FALSE	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	false	true	true	true	false	true	true	false	false	true	true	true	true	true	true	false	false	false	false	true	true	true	true	true	true	false	false
Host association	FALSE	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	N/A	false	false	true	true	false	false	false	true	true	true	true	true	true	true	false	false	true	true	false	false	true	true	false	false	false	false	false	false
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus

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