Mycolicibacterium peregrinum

General Information

Mycolicibacterium peregrinum is a fascinating microorganism belonging to the genus Mycolicibacterium, which is part of the broader family of Mycobacteriaceae. This organism is particularly interesting due to its unique cell wall composition, which includes mycolic acids. These long-chain fatty acids contribute to the organism's resilience and ability to survive in harsh environments, making it a subject of interest in studies related to microbial resistance and persistence. One of the most notable aspects of M. peregrinum is its role in human health. It is an opportunistic pathogen, often associated with infections in immunocompromised individuals. This makes it a valuable model for understanding the mechanisms of pathogenicity and host-pathogen interactions. Researchers are particularly interested in its ability to cause a range of infections, from skin and soft tissue infections to more severe pulmonary diseases. From a biotechnological perspective, M. peregrinum has shown potential in bioremediation. Its robust metabolic pathways enable it to degrade various environmental pollutants, including hydrocarbons and other complex organic compounds. This capability is being explored for applications in cleaning up contaminated environments, making it a valuable organism for environmental microbiology. In addition, the genetic and biochemical pathways of M. peregrinum are of significant interest. The organism's genome has been sequenced, providing insights into its metabolic capabilities and potential for producing novel bioactive compounds. This opens up avenues for research into new antibiotics and other therapeutic agents. Overall, Mycolicibacterium peregrinum stands out due to its medical relevance, environmental applications, and biotechnological potential, making it a multifaceted organism worthy of extensive study.

Mycolicibacterium peregrinum is a species of actinobacteria that has garnered interest due to its unique biochemical properties and ecological significance. This organism is notable for its ability to produce mycolic acids, which are long-chain fatty acids that contribute to the complex cell wall structure typical of the genus. These mycolic acids play a crucial role in the organism's resistance to environmental stresses, making it a fascinating subject for studies on microbial survival mechanisms in harsh conditions. One of the most intriguing aspects of M. peregrinum is its potential role in human health. It has been isolated from various clinical specimens, suggesting that it may be involved in opportunistic infections, particularly in immunocompromised individuals. This raises important questions about its pathogenicity and the mechanisms it employs to evade the host immune response. Additionally, M. peregrinum has been studied for its biotechnological applications. Its unique metabolic pathways and the ability to degrade complex organic compounds make it a candidate for bioremediation efforts, particularly in environments contaminated with hydrocarbons or other pollutants. The organism's capacity to produce bioactive compounds also opens avenues for pharmaceutical research, potentially leading to the discovery of new antibiotics or therapeutic agents. In summary, Mycolicibacterium peregrinum stands out due to its biochemical uniqueness, potential pathogenicity, and biotechnological relevance, making it a valuable organism for both environmental and medical research.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycolicibacterium

Species: Mycolicibacterium peregrinum

NCBI ID

43304

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/025/822/425/GCF_025822425.1_ASM2582242v1

File for sequence-based predictions:
GCF_025822425.1_ASM2582242v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycolicibacterium peregrinum is a member of the genus Mycolicibacterium, which is known for its clinical relevance primarily in the context of infections and its role as an opportunistic pathogen. It has been associated with pulmonary infections, particularly in immunocompromised patients, and can also cause cutaneous infections and soft tissue infections. The pathogenicity of M. peregrinum is attributed to its ability to evade the immune response, often leading to chronic infections that can be difficult to treat. Antimicrobial resistance is a significant concern with M. peregrinum, as it has shown resistance to multiple classes of antibiotics, complicating treatment options. This resistance is often linked to its unique cell wall structure, which contains mycolic acids, contributing to its inherent resistance to certain antimicrobial agents. In terms of medical applications, while M. peregrinum is not typically used as a probiotic or therapeutic agent, understanding its mechanisms of pathogenicity and resistance can inform the development of new treatment strategies. The organism's interactions with the human body highlight the importance of monitoring for potential outbreaks, especially in healthcare settings where vulnerable populations are present. Overall, Mycolicibacterium peregrinum serves as a reminder of the complexities of microbial interactions in human health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycolicibacterium peregrinum is a species of bacteria that is primarily associated with soil environments and human-associated habitats. This microorganism thrives in a variety of ecological niches, particularly in areas where organic matter is abundant, such as decaying plant material and compost. Its ability to degrade complex organic compounds makes it an important player in nutrient cycling within these ecosystems. In soil biomes, Mycolicibacterium peregrinum contributes to the breakdown of organic matter, facilitating the release of nutrients back into the soil. This process is crucial for maintaining soil health and fertility, as it supports plant growth and sustains other microbial communities. Additionally, this bacterium has been found in urban environments, where it can inhabit indoor settings such as homes and hospitals. Here, it may interact with other microorganisms and contribute to the microbial diversity of these environments. Its presence in human-associated habitats raises questions about its role in human health, particularly in relation to opportunistic infections. Overall, Mycolicibacterium peregrinum exemplifies the adaptability of microorganisms to various biomes, showcasing its ecological significance in both natural and anthropogenic environments.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycolicibacterium peregrinum has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to participate in biodegradation processes, making it valuable in the treatment of contaminated environments. For instance, it can break down complex organic compounds, which is crucial in waste treatment facilities aimed at reducing environmental pollutants. In the realm of biofuel production, Mycolicibacterium peregrinum can be utilized in fermentation processes to convert biomass into biofuels. Its metabolic pathways allow for the efficient conversion of sugars into ethanol, which can be harnessed as a renewable energy source. Moreover, this microorganism has been studied for its potential in pharmaceutical development. It produces various bioactive compounds that may have therapeutic properties, contributing to the discovery of new drugs. The enzymatic activity of Mycolicibacterium peregrinum is particularly noteworthy, as it can produce enzymes that are useful in industrial applications, such as in the food industry for enzyme production that enhances flavor and texture. Overall, Mycolicibacterium peregrinum represents a versatile organism with significant implications for sustainable practices in multiple industries.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemma-7b-it	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain negative ✗
Aerophilicity	aerobic	aerobic ✓	N/A	aerobic ✓	N/A	aerobic ✓	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	true	true	false	true	false	true	false	false	false	false	false	false	true	true	true	true	false	false	false	false	true	true	false	false	true	true	false	false
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 1 ✗	biosafety level 1 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	false	false	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	alpha	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗

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