Burkholderia lata

General Information

Burkholderia lata is a fascinating microorganism belonging to the Burkholderia cepacia complex, a group of genetically similar but phenotypically diverse bacteria. One of the most intriguing aspects of B. lata is its versatility and adaptability to various environments, including soil, water, and plant surfaces. This adaptability makes it a subject of interest in environmental microbiology and biotechnology. From a biotechnological perspective, B. lata is notable for its ability to degrade a wide range of organic pollutants, including aromatic compounds and pesticides. This capability positions it as a potential candidate for bioremediation efforts aimed at cleaning up contaminated environments. Additionally, B. lata produces a variety of secondary metabolites with antimicrobial properties, which could be harnessed for developing new antibiotics or biocontrol agents. In agriculture, B. lata has been studied for its plant growth-promoting properties. It can produce plant hormones such as indole-3-acetic acid (IAA) and solubilize phosphate, which can enhance plant growth and yield. This makes it a valuable organism for sustainable agriculture practices. Another unique feature of B. lata is its complex interaction with other microorganisms and hosts. It can form symbiotic relationships with plants, promoting their growth, while also having the potential to act as a pathogen under certain conditions. This dual role adds a layer of complexity to its study, making it a model organism for understanding microbial ecology and host-microbe interactions. Overall, Burkholderia lata is a microorganism of significant interest due to its environmental versatility, biotechnological potential, and complex ecological interactions.**

Burkholderia lata is a fascinating bacterium that belongs to the genus Burkholderia, which is known for its diverse metabolic capabilities and ecological versatility. This organism is particularly interesting due to its ability to thrive in various environments, including soil and water, and its role in the nitrogen cycle. One of the most notable characteristics of B. lata is its capacity to degrade a wide range of organic compounds, making it a valuable player in bioremediation efforts. Researchers are keenly interested in its potential applications for cleaning up contaminated environments, especially those polluted with hydrocarbons and other toxic substances. Additionally, B. lata has been studied for its interactions with plants, where it can promote growth and enhance nutrient uptake. This symbiotic relationship highlights its potential use in sustainable agriculture, particularly in developing biofertilizers that can improve crop yields while minimizing chemical inputs. From a medical perspective, Burkholderia species are known for their opportunistic pathogenicity, particularly in immunocompromised individuals. While B. lata is not as widely recognized as some of its relatives, understanding its pathogenic potential and mechanisms of virulence is crucial for public health, especially in the context of emerging infectious diseases. The genomic and metabolic diversity of B. lata makes it a subject of interest for researchers aiming to explore microbial ecology, biotechnology, and infectious disease management. Its unique characteristics and adaptability underscore the importance of studying this organism in various scientific fields.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Betaproteobacteria

Order: Burkholderiales

Family: Burkholderiaceae

Genus: Burkholderia

Species: Burkholderia lata

NCBI ID

482957

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/012/945/GCA_000012945.1_ASM1294v1

File for sequence-based predictions:
GCA_000012945.1_ASM1294v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Burkholderia lata is a member of the Burkholderia genus, which is known for its clinical significance, particularly in immunocompromised patients. It is associated with a range of infections, including respiratory tract infections, skin infections, and bacteremia. The pathogenicity of Burkholderia lata is attributed to its ability to evade the immune response through various mechanisms, such as the production of biofilms and the secretion of virulence factors that inhibit phagocytosis by immune cells. Antimicrobial resistance is a significant concern with Burkholderia lata, as it exhibits resistance to multiple classes of antibiotics, including beta-lactams and aminoglycosides. This resistance complicates treatment options and necessitates the use of alternative therapies, which may not always be effective. In terms of human health, Burkholderia lata has been implicated in outbreaks, particularly in healthcare settings where patients with underlying conditions are at higher risk. Its role as an opportunistic pathogen highlights the importance of infection control measures in preventing transmission. While Burkholderia lata is not commonly used in medical applications like probiotics or vaccines, understanding its pathogenic mechanisms and resistance profiles is crucial for developing effective treatment strategies and improving patient outcomes in those affected by this organism.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Burkholderia lata is a versatile bacterium commonly associated with a variety of habitats and ecological niches. This microorganism is primarily found in soil and water environments, where it plays a significant role in nutrient cycling and organic matter decomposition. Its ability to thrive in diverse conditions makes it an important player in both terrestrial and aquatic ecosystems. In soil ecosystems, Burkholderia lata contributes to the breakdown of complex organic compounds, enhancing soil fertility and promoting plant growth. It often engages in symbiotic relationships with plants, aiding in nutrient uptake, particularly in nutrient-poor soils. This interaction not only benefits the plants but also helps maintain the microbial diversity within the soil. In aquatic environments, Burkholderia lata can be found in freshwater and marine ecosystems, where it participates in the degradation of organic pollutants. Its metabolic versatility allows it to utilize a wide range of substrates, making it a key player in bioremediation efforts. This bacterium can also interact with other microorganisms, forming complex communities that enhance the overall health of the aquatic biome. Overall, Burkholderia lata exemplifies the adaptability of microorganisms to various biomes, showcasing its essential roles in nutrient cycling, plant health, and environmental remediation.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Burkholderia lata has shown significant potential in various industrial applications. One of the primary areas is in biotechnology, where Burkholderia lata is utilized for its ability to produce a range of enzymes that can be harnessed in biocatalysis processes. These enzymes are particularly valuable in the food industry for applications such as the breakdown of starches and proteins, enhancing flavor and texture in food products. In the realm of waste management, Burkholderia lata has demonstrated capabilities in biodegradation of environmental pollutants, including hydrocarbons and heavy metals. This makes it a candidate for bioremediation strategies aimed at cleaning up contaminated sites, thus contributing to environmental sustainability. Furthermore, Burkholderia lata is being explored for its role in biofuel production. Its metabolic pathways can be optimized for the conversion of biomass into biofuels, particularly through fermentation processes that yield ethanol and other biofuels from agricultural waste. In pharmaceutical development, Burkholderia lata has been studied for its potential to produce bioactive compounds, including antibiotics and other therapeutic agents. The organism's unique metabolic capabilities allow for the synthesis of novel compounds that could lead to new drug discoveries. Overall, Burkholderia lata represents a versatile microorganism with applications spanning biotechnology, waste management, biofuel production, and pharmaceutical development, showcasing its importance in various industrial sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 12

LLM predicted phenotypes: 1

Phenotype	High-quality annotation	anthropic/claude-3-haiku:beta	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-flash-1.5	google/gemma-7b-it	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openchat/openchat-7b	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	google/gemini-pro-1.5	google/gemini-pro-1.5	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4o	openai/gpt-4o	google/gemini-pro	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Biofilm formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Animal pathogenicity	FALSE	true ✗	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	false	true	true	false	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	FALSE	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	gamma	beta ✗	N/A	gamma ✓	alpha ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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