Raoultella ornithinolytica

General Information

Raoultella ornithinolytica is a fascinating microorganism that belongs to the family Enterobacteriaceae. This bacterium is particularly interesting due to its ability to produce ornithine decarboxylase, an enzyme that catalyzes the decarboxylation of ornithine to putrescine, a polyamine involved in cellular growth and differentiation. This metabolic capability is relatively rare and can be a point of interest for researchers studying polyamine metabolism and its implications in various biological processes. Another notable feature of R. ornithinolytica is its potential for bioremediation. This bacterium has been found to degrade a variety of environmental pollutants, including hydrocarbons and heavy metals, making it a valuable candidate for cleaning up contaminated environments. Its ability to thrive in diverse and often harsh conditions further underscores its utility in environmental applications. From a clinical perspective, Raoultella ornithinolytica has been isolated from various human infections, including urinary tract infections, respiratory tract infections, and wound infections. Its presence in clinical settings highlights the importance of understanding its pathogenic potential and developing effective treatment strategies. The bacterium's resistance to multiple antibiotics also makes it a subject of interest in the study of antimicrobial resistance mechanisms. In summary, Raoultella ornithinolytica is a microorganism of significant interest due to its unique metabolic capabilities, potential applications in bioremediation, and clinical relevance. Its diverse roles in both environmental and medical contexts make it a valuable subject for ongoing research and study.

Raoultella ornithinolytica is a fascinating bacterium that belongs to the family Enterobacteriaceae. This organism is particularly notable for its ability to degrade a variety of complex organic compounds, including those found in the environment and in industrial waste. Its metabolic versatility allows it to thrive in diverse habitats, making it an interesting subject for ecological and environmental studies. One of the most intriguing aspects of R. ornithinolytica is its capacity to utilize ornithine as a sole carbon and nitrogen source, which is relatively rare among bacteria. This unique metabolic pathway not only highlights the organism's adaptability but also opens avenues for research into bioremediation strategies, where it could potentially be employed to break down pollutants in contaminated environments. Furthermore, R. ornithinolytica has been isolated from various sources, including clinical specimens, which raises questions about its role in human health and disease. While it is not typically associated with pathogenicity, its presence in clinical settings suggests that it may have implications for opportunistic infections, particularly in immunocompromised individuals. This duality of being both an environmental microbe and a potential clinical isolate makes R. ornithinolytica a valuable organism for studying microbial ecology and the dynamics of host-microbe interactions. In summary, the unique metabolic capabilities and ecological versatility of Raoultella ornithinolytica make it a significant organism for research in environmental microbiology, bioremediation, and the understanding of microbial roles in health and disease.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Gammaproteobacteria

Order: Enterobacterales

Family: Enterobacteriaceae

Genus: Raoultella

Species: Raoultella ornithinolytica

NCBI ID

54291

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/025/349/945/GCF_025349945.1_ASM2534994v1

File for sequence-based predictions:
GCF_025349945.1_ASM2534994v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Raoultella ornithinolytica is a member of the Enterobacteriaceae family and has been associated with various clinical implications. It is primarily known for its role as an opportunistic pathogen, particularly in immunocompromised patients. Infections caused by R. ornithinolytica can lead to serious conditions such as bacteremia, pneumonia, and urinary tract infections. The organism is often isolated from clinical specimens, indicating its potential to cause nosocomial infections in healthcare settings. One of the significant concerns regarding R. ornithinolytica is its antimicrobial resistance. It has been documented to exhibit resistance to multiple classes of antibiotics, including beta-lactams and aminoglycosides, which complicates treatment options for infected patients. This resistance is often attributed to the presence of various resistance genes and mechanisms, such as the production of extended-spectrum beta-lactamases (ESBLs). In terms of immune evasion, R. ornithinolytica can manipulate host immune responses, allowing it to persist in the human body despite the presence of an active immune system. This ability to evade detection and clearance contributes to its pathogenicity and the severity of infections it can cause. While R. ornithinolytica is primarily recognized for its pathogenic potential, it is also studied for its role in the human microbiome. Some strains may have beneficial properties, although this aspect is less well-documented compared to its pathogenic characteristics. Overall, the clinical relevance of R. ornithinolytica underscores the need for ongoing surveillance and research to better understand its role in human health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Raoultella ornithinolytica is a gram-negative bacterium commonly found in various aquatic environments and soil ecosystems. This microorganism thrives in freshwater habitats, such as rivers and lakes, where it plays a significant role in the nutrient cycling processes. It is often associated with decaying organic matter, contributing to the breakdown of complex organic compounds and thus enhancing soil fertility and water quality. In addition to its presence in natural environments, R. ornithinolytica has been isolated from human-made environments, including wastewater treatment plants and industrial effluents. Here, it can participate in the degradation of pollutants, showcasing its potential in bioremediation efforts. Notably, R. ornithinolytica exhibits a symbiotic relationship with various organisms, including plants, where it can enhance nutrient uptake, particularly nitrogen. This interaction underscores its importance in agricultural ecosystems, where it may contribute to sustainable farming practices by improving soil health and plant growth. Furthermore, this bacterium is known for its adaptability to varying environmental conditions, including changes in temperature and salinity, which allows it to colonize diverse habitats. Its ability to thrive in both aerobic and anaerobic conditions further emphasizes its ecological versatility. Overall, Raoultella ornithinolytica is a vital component of its ecosystems, influencing both biogeochemical cycles and the health of its habitats.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Raoultella ornithinolytica has shown significant potential in various industrial applications. One of the primary areas of interest is in biotechnology, where Raoultella ornithinolytica is utilized for its ability to perform fermentation processes. This organism can convert carbohydrates into organic acids, which can be harnessed for the production of valuable metabolites such as lactic acid, a precursor for biodegradable plastics and food preservatives. In the realm of waste management, Raoultella ornithinolytica has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic compounds found in wastewater. This makes it a candidate for use in bioremediation strategies aimed at treating contaminated environments, thereby reducing the ecological impact of industrial waste. Furthermore, the organism has been explored for its role in biofuel production. Its metabolic pathways can be optimized to enhance the yield of bioethanol from agricultural residues, contributing to sustainable energy solutions. The efficiency of Raoultella ornithinolytica in fermentation processes can lead to improved methods for converting biomass into renewable energy sources. In pharmaceutical development, Raoultella ornithinolytica has been studied for its potential in producing enzymes that can be used in drug synthesis and as biocatalysts in various chemical reactions. The enzymatic activity of this microorganism can facilitate the development of new therapeutic compounds, showcasing its versatility in the pharmaceutical industry. Overall, Raoultella ornithinolytica presents a multifaceted approach to addressing industrial challenges through its applications in biotechnology, waste management, biofuel production, and pharmaceutical development, making it a valuable organism in the field of industrial microbiology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	anthropic/claude-3-haiku:beta	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	google/palm-2-chat-bison-32k	mistralai/mistral-7b-instruct	microsoft/phi-3-mini-128k-instruct	openchat/openchat-7b	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	google/gemini-pro	google/gemma-7b-it	google/gemma-7b-it	google/gemini-pro-1.5	google/gemini-pro-1.5
Motility	TRUE	false ✗	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	N/A	facultatively anaerobic	N/A	facultatively anaerobic	facultatively anaerobic	N/A	facultatively anaerobic	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic	facultatively anaerobic	aerotolerant	aerotolerant	facultatively anaerobic	facultatively anaerobic	facultatively anaerobic	facultatively anaerobic	facultatively anaerobic	facultatively anaerobic	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	alpha	beta	beta	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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