Kluyvera intermedia

General Information

Kluyvera intermedia is a fascinating microorganism belonging to the family Enterobacteriaceae. This bacterium is particularly interesting due to its ability to produce a wide range of enzymes that are valuable in various biotechnological applications. One of the most notable enzymes produced by K. intermedia is β-lactamase, which has significant implications in the study of antibiotic resistance. The presence of β-lactamase allows this bacterium to break down β-lactam antibiotics, making it a model organism for understanding resistance mechanisms. Another unique aspect of Kluyvera intermedia is its potential role in bioremediation. This bacterium has been studied for its ability to degrade environmental pollutants, including certain aromatic compounds. This makes it a candidate for use in cleaning up contaminated environments, contributing to environmental sustainability. From a clinical perspective, K. intermedia is also noteworthy. Although it is not a common pathogen, it has been isolated from various clinical specimens, indicating its potential to cause opportunistic infections. This highlights the importance of monitoring and studying this bacterium in healthcare settings to better understand its pathogenic potential and develop appropriate treatment strategies. In summary, Kluyvera intermedia is a microorganism of significant interest due to its enzyme production capabilities, role in antibiotic resistance research, and potential applications in bioremediation. Its occasional presence in clinical settings also underscores the need for ongoing research to fully elucidate its characteristics and implications.

Kluyvera intermedia is a fascinating member of the Enterobacteriaceae family, notable for its unique metabolic capabilities and ecological versatility. This bacterium is primarily found in environmental sources such as soil and water, as well as in the gastrointestinal tracts of various animals, which highlights its adaptability to diverse habitats. One of the most interesting aspects of K. intermedia is its ability to utilize a wide range of carbon sources, including certain amino acids and organic acids, which makes it a valuable organism for studies in microbial metabolism and biogeochemical cycles. This metabolic flexibility allows it to thrive in nutrient-variable environments, contributing to its ecological significance. Moreover, K. intermedia has garnered attention in clinical microbiology due to its occasional isolation from human clinical specimens, particularly in immunocompromised patients. This raises important questions regarding its pathogenic potential and the mechanisms underlying its interactions with the human host. Understanding these interactions could provide insights into the behavior of opportunistic pathogens and the dynamics of microbial communities in health and disease. In addition, research on K. intermedia may contribute to the development of biotechnological applications, particularly in the fields of waste treatment and bioremediation, where its metabolic capabilities can be harnessed to degrade pollutants or convert waste into useful products. Overall, Kluyvera intermedia stands out as a microbe of interest not only for its ecological roles but also for its implications in health and biotechnology.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Gammaproteobacteria

Order: Enterobacterales

Family: Enterobacteriaceae

Genus: Kluyvera

Species: Kluyvera intermedia

NCBI ID

61648

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/009/649/915/GCF_009649915.1_ASM964991v1

File for sequence-based predictions:
GCF_009649915.1_ASM964991v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Kluyvera intermedia is a Gram-negative bacterium that has been increasingly recognized in clinical microbiology. It is primarily associated with infections in immunocompromised patients, particularly those with underlying conditions such as diabetes or malignancies. While it is not a common pathogen, it has been implicated in cases of bacteremia, pneumonia, and urinary tract infections (UTIs). The clinical significance of Kluyvera intermedia lies in its potential to cause opportunistic infections, especially in patients with weakened immune systems. One of the notable aspects of Kluyvera intermedia is its antimicrobial resistance profile. It has shown resistance to multiple classes of antibiotics, including beta-lactams and aminoglycosides, which complicates treatment options. This resistance is often attributed to the presence of plasmids that carry resistance genes, making it a concern in healthcare settings where antibiotic stewardship is critical. In terms of immune evasion, Kluyvera intermedia may employ various strategies to survive within the host, including the production of biofilms and the ability to modulate the host's immune response. These mechanisms can hinder effective clearance by the immune system, leading to persistent infections. Although Kluyvera intermedia is not typically associated with large outbreaks, its detection in clinical specimens highlights the importance of accurate identification and susceptibility testing in managing infections caused by this organism. Further research is needed to fully understand its pathogenic mechanisms and potential role in human health.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Kluyvera intermedia is a bacterium commonly associated with various habitats and environments that reflect its ecological versatility. This microorganism is primarily found in soil and water ecosystems, where it plays a significant role in nutrient cycling and organic matter decomposition. Its presence in these environments contributes to the overall health and stability of the ecosystem by facilitating the breakdown of complex organic compounds into simpler forms that can be utilized by other organisms. In aquatic environments, Kluyvera intermedia has been identified in both freshwater and marine systems. Here, it often thrives in nutrient-rich conditions, such as those found in polluted waters or wastewater treatment facilities. Its ability to degrade various organic pollutants makes it an important player in bioremediation processes, helping to restore ecological balance in contaminated habitats. In terrestrial ecosystems, this bacterium is frequently isolated from agricultural soils, where it can enhance soil fertility through its interactions with plant roots. Kluyvera intermedia may engage in symbiotic relationships with plants, promoting nutrient uptake and improving plant health. This interaction underscores its role in supporting biodiversity and plant productivity in agricultural settings. Overall, Kluyvera intermedia exemplifies the adaptability of microorganisms to diverse biomes, showcasing its importance in both natural and managed ecosystems. Its contributions to nutrient cycling, pollution degradation, and plant health highlight its ecological significance and the intricate relationships it maintains within its environments.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Kluyvera intermedia has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to participate in fermentation processes, which can be harnessed for the production of valuable metabolites and bioactive compounds. For instance, Kluyvera intermedia can be utilized in the fermentation of sugars to produce organic acids, which are important in the food and chemical industries. In the realm of waste management, Kluyvera intermedia has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic pollutants. This makes it a candidate for bioremediation strategies aimed at cleaning up contaminated environments, such as soil and water affected by industrial waste. Moreover, the enzymatic activity of Kluyvera intermedia is noteworthy, as it can produce various enzymes that are useful in biotechnology applications, including the degradation of lignocellulosic materials. This property is particularly relevant for biofuel production, where the breakdown of biomass into fermentable sugars is a critical step in the conversion to bioethanol. In pharmaceutical development, the metabolites produced by Kluyvera intermedia during fermentation processes may have therapeutic properties, making it a subject of interest for the discovery of new drugs or health supplements. Overall, the versatility of Kluyvera intermedia in these industrial applications highlights its potential as a valuable microorganism in sustainable practices and innovative technologies.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	anthropic/claude-3-haiku:beta	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro-1.5	perplexity/llama-3-sonar-small-32k-chat	google/palm-2-chat-bison-32k	mistralai/mistral-7b-instruct	google/gemini-pro	openchat/openchat-7b	openai/gpt-4	openai/gpt-4	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	google/gemma-7b-it	google/gemma-7b-it	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain variable ✗	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	false	false	true	false	true	true	false	false	true	true	true	true	false	false	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	TRUE	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	gamma	alpha	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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