Mycobacterium marseillense

General Information

Mycobacterium marseillense is a member of the Mycobacterium avium complex (MAC), a group of genetically related bacteria that are known for their clinical significance and environmental resilience. This species was first isolated from human clinical samples, indicating its potential role in human disease. One of the most interesting aspects of M. marseillense is its genetic similarity to other members of the MAC, which makes it a subject of study for understanding the genetic diversity and pathogenic mechanisms within this group. M. marseillense is particularly notable for its resistance to common antibiotics, which poses challenges for treatment and makes it a critical focus for research into new antimicrobial therapies. Its genome has been sequenced, providing valuable insights into the genetic basis of its pathogenicity and resistance mechanisms. From a research perspective, M. marseillense is valuable for studying the evolutionary relationships within the MAC and for developing diagnostic tools that can accurately differentiate between closely related species. This is crucial for effective clinical management and epidemiological tracking of infections caused by MAC members. Overall, Mycobacterium marseillense stands out due to its clinical relevance, genetic characteristics, and the challenges it presents in terms of treatment and diagnosis, making it a significant organism in the field of microbiology and infectious disease research.

Mycobacterium marseillense is a species of the genus Mycobacterium that has garnered interest due to its unique ecological niche and potential implications in human health. This organism is primarily known for its environmental resilience, thriving in various habitats, including soil and water, which makes it a subject of study in environmental microbiology. Its ability to survive in harsh conditions is attributed to its robust cell wall structure, rich in mycolic acids, which provides protection against desiccation and chemical stressors. One of the most intriguing aspects of M. marseillense is its genetic diversity and the potential for antibiotic resistance. Research has indicated that this species may harbor genes that confer resistance to multiple antibiotics, raising concerns about its role in public health, especially in immunocompromised individuals. This characteristic makes it a valuable organism for studying the mechanisms of resistance and the evolution of pathogenic traits in mycobacteria. Additionally, M. marseillense has been isolated from clinical specimens, suggesting it may be an opportunistic pathogen. This aspect opens avenues for research into its pathogenicity, virulence factors, and the host immune response. Understanding these interactions is crucial for developing effective treatment strategies and public health policies. In summary, Mycobacterium marseillense stands out due to its environmental adaptability, potential antibiotic resistance, and implications for human health. Its study not only contributes to our understanding of mycobacterial biology but also highlights the importance of monitoring environmental microorganisms that may impact human health.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Mycobacteriaceae

Genus: Mycobacterium

Species: Mycobacterium marseillense

NCBI ID

701042

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/285/715/GCF_002285715.1_ASM228571v1

File for sequence-based predictions:
GCF_002285715.1_ASM228571v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Mycobacterium marseillense is a member of the Mycobacterium genus, which is known for its clinical significance in human health. This species has been associated with pulmonary infections and is particularly relevant in immunocompromised patients. Clinical implications of M. marseillense include its potential role in causing nontuberculous mycobacterial infections, which can lead to chronic respiratory symptoms and may mimic tuberculosis. One of the notable aspects of M. marseillense is its pathogenicity, which is linked to its ability to evade the immune response through various mechanisms, including the modulation of macrophage function. This evasion can result in persistent infections that are difficult to treat. In terms of antimicrobial resistance, M. marseillense has shown resistance to several first-line antitubercular drugs, which complicates treatment options and necessitates the use of second-line therapies. This resistance underscores the importance of accurate identification and susceptibility testing in clinical settings. While M. marseillense is not as widely recognized as other mycobacterial species, its emergence in clinical cases highlights the need for awareness among healthcare providers, particularly in regions where it has been reported. Further research is essential to fully understand its epidemiology, pathogenic mechanisms, and potential therapeutic strategies.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Mycobacterium marseillense is a species of bacteria that is primarily associated with urban environments and human-associated habitats. This microorganism has been isolated from various sources, including soil and water, indicating its adaptability to different ecological niches. It is particularly notable for its presence in contaminated water sources and wastewater treatment facilities, where it can thrive in the presence of organic matter and pollutants. In terms of its ecological role, Mycobacterium marseillense is involved in the decomposition of organic materials, contributing to nutrient cycling within its habitat. Its ability to degrade complex compounds allows it to play a significant role in bioremediation, helping to clean up contaminated environments. Additionally, this microorganism may exhibit symbiotic relationships with other microbial communities, enhancing the overall biodiversity and functionality of the ecosystem. Its presence in urban settings highlights its potential as an indicator organism for environmental health, particularly in assessing the impact of human activities on microbial diversity. Overall, Mycobacterium marseillense demonstrates a remarkable ability to adapt to various habitats, making it a key player in the microbial dynamics of both natural and anthropogenic environments.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Mycobacterium marseillense has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to degrade complex organic compounds, making it a candidate for biodegradation processes in contaminated environments. Its enzymatic activity can facilitate the breakdown of pollutants, thus contributing to effective waste treatment solutions. In the realm of biofuel production, Mycobacterium marseillense may play a role in the conversion of biomass into biofuels through fermentation processes. By utilizing its metabolic pathways, this microorganism can potentially enhance the efficiency of biofuel generation from organic waste materials. Furthermore, there is ongoing research into the pharmaceutical development potential of Mycobacterium marseillense. Its unique metabolic properties may lead to the discovery of novel compounds that could be used in drug formulation, particularly in the development of antibiotics or other therapeutic agents. The organism's ability to produce specific enzymes could also be harnessed for enzyme production, which is crucial in various industrial applications, including food processing and biocatalysis. Overall, Mycobacterium marseillense presents a promising avenue for innovation in biotechnology, waste management, and pharmaceuticals, with its capabilities in biodegradation, fermentation, and enzyme production being particularly noteworthy.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/palm-2-chat-bison-32k	anthropic/claude-3.5-sonnet	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro-1.5	perplexity/llama-3-sonar-small-32k-chat	anthropic/claude-3-haiku:beta	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-4	openai/gpt-4	mistralai/mistral-7b-instruct	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4o	openai/gpt-4o	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	openchat/openchat-7b	openchat/openchat-7b	google/gemma-7b-it	google/gemma-7b-it	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro
Motility	FALSE	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	N/A
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	aerobic ✓	aerobic ✓	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	N/A	false	false	false	false	true	true	true	false	false	false	true	false	false	false	false	false	false	true	true	true	true	false	false	true	true	true	true
Biofilm formation	N/A	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	false	false	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

Back to Search