Prevotella jejuni

General Information

Prevotella jejuni is a fascinating microorganism that belongs to the genus Prevotella, which is known for its role in the human oral and gut microbiomes. This species is particularly interesting due to its metabolic versatility and its ability to thrive in diverse environments within the human body. One of the most notable characteristics of Prevotella jejuni is its ability to degrade complex carbohydrates. This capability is crucial for the breakdown of dietary fibers and other polysaccharides that are otherwise indigestible by human enzymes. The metabolic products of this degradation process can have significant implications for human health, influencing gut health and potentially playing a role in conditions such as irritable bowel syndrome (IBS) and other gastrointestinal disorders. Additionally, Prevotella jejuni has been studied for its interactions with the host immune system. It has been observed that certain species within the Prevotella genus can modulate immune responses, which may have both beneficial and detrimental effects depending on the context. This makes Prevotella jejuni a valuable subject for research into the microbiome's impact on immune function and inflammation. From a research perspective, Prevotella jejuni is also of interest due to its potential role in oral health. Members of the Prevotella genus are commonly found in the oral cavity and have been associated with both health and disease states, including periodontitis. Understanding the specific contributions of Prevotella jejuni to oral microbiota dynamics can provide insights into the prevention and treatment of oral diseases. In summary, Prevotella jejuni is a microorganism of significant interest due to its metabolic capabilities, immune interactions, and relevance to human health. Its study can contribute to a deeper understanding of the complex relationships between the human microbiome and overall health.

Prevotella jejuni is a fascinating member of the Prevotella genus, known for its role in the human microbiome and its association with various health conditions. This anaerobic bacterium is primarily found in the gastrointestinal tract and is notable for its ability to metabolize a wide range of carbohydrates, particularly complex polysaccharides. This metabolic versatility allows P. jejuni to thrive in diverse environments, making it a key player in gut ecology. One of the most interesting aspects of Prevotella jejuni is its potential link to human health and disease. Research has indicated that variations in the abundance of Prevotella species, including P. jejuni, may be associated with conditions such as obesity, inflammatory bowel disease, and even certain metabolic disorders. This connection highlights the importance of understanding the role of gut microbiota in overall health and disease mechanisms. Furthermore, P. jejuni has been studied for its interactions with other gut microorganisms, contributing to the complex dynamics of the gut microbiome. Its ability to influence the composition and function of microbial communities makes it a valuable organism for research in microbiology and health sciences. In addition to its ecological significance, Prevotella jejuni is also of interest in the field of biotechnology. Its unique metabolic pathways may offer potential applications in the development of probiotics or in the fermentation industry, where its carbohydrate-degrading capabilities could be harnessed for the production of biofuels or other bioproducts. This potential for biotechnological applications further underscores the value of studying P. jejuni and its relatives.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacteroidota

Class: Bacteroidia

Order: Bacteroidales

Family: Prevotellaceae

Genus: Prevotella

Species: Prevotella jejuni

NCBI ID

1177574

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/849/795/GCF_002849795.1_ASM284979v1

File for sequence-based predictions:
GCF_002849795.1_ASM284979v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Prevotella jejuni is a member of the genus Prevotella, which is known for its role in the human microbiome. It is primarily associated with the oral cavity and the gastrointestinal tract, where it plays a role in the digestion of complex carbohydrates. However, its clinical implications are significant, particularly in relation to infections and disease associations. Pathogenicity: Prevotella jejuni has been implicated in various infections, including periodontal disease and abscess formation. It is often found in polymicrobial infections, where it can contribute to the severity of the disease. Its presence in the oral cavity can lead to systemic infections if it enters the bloodstream, particularly in immunocompromised individuals. Immune Evasion Strategies: This organism has developed several mechanisms to evade the immune response, including the production of polysaccharide capsules that inhibit phagocytosis and the ability to modulate host immune responses, which can lead to chronic inflammation. Antimicrobial Resistance: There is growing concern regarding the antimicrobial resistance of Prevotella jejuni. Resistance to commonly used antibiotics, such as beta-lactams and macrolides, has been documented, complicating treatment options for infections caused by this organism. Medical Applications: While Prevotella jejuni is primarily viewed in a negative light due to its association with disease, some species within the Prevotella genus are being studied for their potential role as probiotics. These beneficial strains may help in maintaining gut health and preventing dysbiosis, although further research is needed to fully understand their therapeutic potential. In summary, Prevotella jejuni is a clinically relevant microorganism with implications in oral health, systemic infections, and antimicrobial resistance, highlighting the need for continued research and awareness in clinical settings.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Prevotella jejuni is a species of bacteria commonly found in the gastrointestinal tract of various animals, particularly in the intestines of mammals and birds. This organism thrives in a microaerophilic environment, which is characterized by low levels of oxygen, making it well-adapted to the conditions found in the gut. The presence of Prevotella jejuni is often associated with the breakdown of complex carbohydrates, contributing to the fermentation processes that occur in the intestines. This role is crucial for the digestion of dietary fibers, which are otherwise indigestible by the host organism. In terms of ecological interactions, Prevotella jejuni plays a significant role in the gut microbiome, where it participates in symbiotic relationships with its host. By aiding in the digestion of food, it helps maintain the health of the host's digestive system. Additionally, it can influence the immune response of the host, highlighting its importance in maintaining a balanced gut ecosystem. Furthermore, Prevotella jejuni is known to interact with other microbial species within the gut, contributing to the overall diversity and stability of the microbiome. This interaction can lead to competitive advantages for certain microbial populations, affecting the overall health and metabolic functions of the host. Overall, the habitats associated with Prevotella jejuni are primarily the intestinal tracts of various animals, where it thrives in a complex community of microorganisms, playing a vital role in digestion and nutrient absorption.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Prevotella jejuni has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its role in the fermentation of carbohydrates, which can be harnessed for the production of bioactive compounds and organic acids. In the context of biofuel production, Prevotella jejuni can contribute to the breakdown of complex carbohydrates, facilitating the conversion of biomass into fermentable sugars that can be further processed into biofuels such as ethanol. In waste management, Prevotella jejuni plays a significant role in the biodegradation of organic waste, particularly in anaerobic digestion processes. This capability allows for the effective treatment of agricultural and food waste, leading to the production of biogas, which can be utilized as a renewable energy source. Furthermore, the enzymatic activity of Prevotella jejuni in breaking down polysaccharides enhances the efficiency of these waste treatment processes. Additionally, there is ongoing research into the potential of Prevotella jejuni in pharmaceutical development, particularly in the synthesis of novel metabolites that may have therapeutic properties. The organism's unique metabolic pathways could lead to the discovery of new drugs or health supplements, emphasizing its importance in the biopharmaceutical industry. Overall, Prevotella jejuni demonstrates a versatile range of applications across multiple sectors, making it a valuable microorganism in industrial biotechnology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	anthropic/claude-3-haiku:beta	meta-llama/llama-3-8b-instruct:nitro	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	perplexity/llama-3-sonar-small-32k-chat	google/palm-2-chat-bison-32k	openchat/openchat-7b	google/gemini-pro	google/gemma-7b-it	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4	openai/gpt-4	openai/gpt-4o	openai/gpt-4o	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro
Motility	FALSE	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	anaerobic	N/A	aerotolerant ✗	N/A	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	beta	N/A	gamma	N/A	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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