Finegoldia magna

General Information

Finegoldia magna is a fascinating microorganism that belongs to the family Peptoniphilaceae. This bacterium is particularly interesting due to its role as a commensal organism in the human body, predominantly found in the skin and mucous membranes. However, it can also act as an opportunistic pathogen, especially in immunocompromised individuals or those with disrupted skin barriers. One of the key characteristics of Finegoldia magna is its ability to produce a variety of virulence factors, which contribute to its pathogenic potential. For instance, it secretes a protein called Finegoldia magna adhesion factor (FAF), which facilitates its adherence to host tissues and evasion of the immune system. Additionally, it produces protein L, an immunoglobulin-binding protein that can interfere with the host's immune response. From a research perspective, Finegoldia magna is valuable due to its unique interactions with the host immune system. Studies have shown that it can modulate the immune response, potentially leading to chronic inflammation or persistent infections. This makes it a model organism for studying host-pathogen interactions and the mechanisms of immune evasion. Moreover, Finegoldia magna has been implicated in a variety of clinical conditions, including soft tissue infections, bone and joint infections, and bacteremia. Its ability to form complex communities with other microorganisms, such as in polymicrobial infections, adds another layer of complexity and interest for researchers studying microbial ecology and pathogenesis. In summary, Finegoldia magna is a microorganism of significant interest due to its dual role as a commensal and opportunistic pathogen, its production of virulence factors, and its interactions with the host immune system. These characteristics make it a valuable subject for research in microbiology, immunology, and infectious diseases.

Finegoldia magna is a notable anaerobic bacterium that belongs to the genus Finegoldia. This organism is particularly interesting due to its role as a commensal inhabitant of the human microbiota, primarily found in the gastrointestinal tract and on the skin. Its presence in these environments suggests a potential contribution to maintaining microbial balance and health. One of the unique aspects of Finegoldia magna is its association with various human infections, particularly in immunocompromised individuals. It has been implicated in soft tissue infections, abscesses, and even endocarditis, making it a significant pathogen in clinical settings. This dual role as both a commensal and a pathogen provides a fascinating area of study for researchers interested in microbial pathogenesis and host-microbe interactions. Furthermore, Finegoldia magna is of interest in the field of antibiotic resistance. Studies have shown that it can exhibit resistance to multiple antibiotics, which raises concerns regarding treatment options for infections caused by this organism. Understanding the mechanisms behind its resistance can provide valuable insights into the broader issue of antibiotic resistance in anaerobic bacteria. In summary, Finegoldia magna stands out not only for its clinical relevance but also for its complex role within the human microbiome, making it a valuable subject for ongoing research in microbiology and infectious diseases.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Tissierellia

Order: Tissierellales

Family: Peptoniphilaceae

Genus: Finegoldia

Species: Finegoldia magna

NCBI ID

1260

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/013/267/535/GCA_013267535.1_ASM1326753v1

File for sequence-based predictions:
GCA_013267535.1_ASM1326753v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Finegoldia magna is a Gram-positive anaerobic bacterium that is part of the normal flora of the human skin and mucosal surfaces. However, it has significant clinical implications as it is associated with various infections and can act as an opportunistic pathogen. It is particularly known for its role in soft tissue infections, bone infections, and endocarditis, especially in individuals with compromised immune systems or underlying health conditions. Pathogenicity of Finegoldia magna is attributed to its ability to evade the immune response through various mechanisms, including the production of enzymes that degrade host tissues and the formation of biofilms, which protect it from phagocytosis and antibiotic action. In terms of antimicrobial resistance, Finegoldia magna has shown resistance to several commonly used antibiotics, including penicillin and clindamycin, which complicates treatment options for infections caused by this organism. This resistance is often due to the acquisition of resistance genes and the intrinsic properties of anaerobic bacteria. Moreover, Finegoldia magna has been implicated in outbreaks of infections in clinical settings, particularly in patients with surgical wounds or those undergoing invasive procedures. Its presence in polymicrobial infections further complicates the clinical picture, necessitating a comprehensive approach to diagnosis and treatment. While Finegoldia magna is primarily recognized for its pathogenic potential, it is also studied for its role in the human microbiome and its potential applications in probiotics and therapeutics, although this area requires further research to establish clear benefits. Overall, understanding the clinical implications of Finegoldia magna is crucial for effective management of infections and improving patient outcomes.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Finegoldia magna is a gram-positive anaerobic bacterium commonly found in the human microbiome, particularly in the oral cavity, gastrointestinal tract, and female genital tract. This organism thrives in anaerobic environments, where oxygen levels are low, allowing it to flourish alongside other anaerobic bacteria. Its presence is crucial for maintaining a balanced microbial community, contributing to the overall health of its host by aiding in digestion and nutrient absorption. In the oral cavity, F. magna plays a role in the breakdown of complex carbohydrates, which can help prevent the overgrowth of pathogenic bacteria. This symbiotic relationship is essential for oral health, as it helps maintain a balanced ecosystem that can resist infections. In the gastrointestinal tract, Finegoldia magna is involved in the fermentation of dietary fibers, producing short-chain fatty acids that are beneficial for gut health. These metabolites not only provide energy to colon cells but also play a role in modulating the immune response, highlighting the organism's importance in gut microbiota dynamics. Additionally, F. magna has been associated with certain infections, particularly in immunocompromised individuals, indicating its potential pathogenicity under specific conditions. This dual role as both a beneficial and potentially harmful organism underscores the complexity of its interactions within the human microbiome and its adaptability to various microbial niches.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Finegoldia magna has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This anaerobic bacterium is known for its role in biodegradation, where it can effectively break down complex organic materials, making it valuable in the treatment of waste. Its ability to degrade various substrates can be harnessed in waste treatment processes, contributing to the reduction of environmental pollutants and the enhancement of waste management systems. In the realm of biofuel production, Finegoldia magna may play a role in the fermentation of organic waste to produce biogas, a renewable energy source. The bacterium's metabolic pathways can facilitate the conversion of organic matter into methane, which can be captured and utilized as a clean energy alternative. Additionally, Finegoldia magna has been studied for its potential in pharmaceutical development. Its unique enzymatic activities may lead to the discovery of novel compounds that could be used in drug formulation or as biocatalysts in various chemical reactions. The exploration of its metabolic products could yield important insights into new therapeutic agents. Overall, the applications of Finegoldia magna in fermentation, biodegradation, and enzyme production highlight its significance in advancing sustainable practices across multiple industries.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3-haiku:beta	openai/gpt-4	openai/gpt-4	openai/gpt-4o	openai/gpt-4o	google/gemini-flash-1.5	google/gemma-7b-it	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	openchat/openchat-7b	google/gemini-pro	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro-1.5	google/gemini-pro-1.5	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Gram staining	gram stain positive	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗
Aerophilicity	anaerobic	N/A	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	anaerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	anaerobic ✓	anaerobic ✓	aerotolerant ✗	aerotolerant ✗	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	alpha	beta	beta	gamma	gamma	alpha	alpha	N/A	gamma	gamma	gamma	gamma	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	coccus	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	bacillus ✗	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	bacillus ✗	bacillus ✗	coccus ✓	coccus ✓	bacillus ✗	bacillus ✗	coccus ✓	coccus ✓

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