Weissella cibaria

General Information

Weissella cibaria is a lactic acid bacterium that has garnered significant interest due to its probiotic potential and health-promoting properties. This microorganism is commonly found in fermented foods, such as kimchi and sourdough, and is known for its ability to produce exopolysaccharides, which contribute to the texture and mouthfeel of these foods. One of the most intriguing aspects of Weissella cibaria is its antimicrobial activity. It produces bacteriocins, which are proteinaceous toxins that inhibit the growth of pathogenic bacteria, making it a valuable candidate for natural food preservation. Additionally, Weissella cibaria has been studied for its role in oral health, as it can inhibit the growth of harmful oral bacteria and reduce dental plaque formation. From a research perspective, Weissella cibaria is also notable for its immune-modulating effects. Studies have shown that it can enhance the immune response, making it a potential candidate for developing functional foods aimed at boosting immunity. Furthermore, its ability to survive and colonize the gastrointestinal tract makes it a promising probiotic for improving gut health. Overall, Weissella cibaria stands out due to its multifaceted benefits in food technology, health promotion, and disease prevention, making it a microorganism of considerable interest in both scientific research and commercial applications.

Weissella cibaria is a lactic acid bacterium that is particularly notable for its role in the fermentation of various food products, especially in traditional Asian cuisines. This organism is often found in fermented vegetables and dairy products, contributing to the unique flavors and textures of these foods. One of the most interesting aspects of W. cibaria is its ability to produce a variety of metabolites, including exopolysaccharides, which can enhance the texture and mouthfeel of fermented products. Moreover, Weissella cibaria has been studied for its potential health benefits, including probiotic properties. Research has indicated that it may possess immunomodulatory effects, which could be valuable in developing functional foods aimed at improving gut health. This bacterium is also of interest in the context of food safety, as it can inhibit the growth of certain pathogenic microorganisms, making it a potential candidate for use as a natural preservative in food products. In addition to its applications in food science, W. cibaria has been explored for its genetic and metabolic pathways, providing insights into the mechanisms of fermentation and the production of beneficial compounds. Its relatively simple genome and the ease of culturing make it an attractive model organism for studying lactic acid bacteria. Overall, Weissella cibaria stands out not only for its contributions to food fermentation but also for its potential applications in health and food safety, making it a valuable subject of research in microbiology and food science.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Bacilli

Order: Lactobacillales

Family: Lactobacillaceae

Genus: Weissella

Species: Weissella cibaria

NCBI ID

137591

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/951/095/GCF_001951095.1_ASM195109v1

File for sequence-based predictions:
GCF_001951095.1_ASM195109v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Weissella cibaria is a Gram-positive, non-spore-forming bacterium that is part of the lactic acid bacteria group. It is primarily found in fermented foods and the human oral cavity, where it plays a role in the microbiome of the mouth. Its clinical relevance is multifaceted, particularly in the context of human health and disease associations. Role in Human Health: Weissella cibaria is known for its potential probiotic properties, contributing to gut health and possibly enhancing the immune response through the production of beneficial metabolites such as lactic acid. It may help in maintaining a balanced microbiota, which is crucial for preventing dysbiosis and associated diseases. Disease Associations: While Weissella cibaria is generally considered non-pathogenic, there have been rare reports of its involvement in infections, particularly in immunocompromised individuals. Its presence in the oral cavity has been linked to dental health, where it may influence the development of periodontal disease. Pathogenicity: Although not typically classified as a pathogen, its opportunistic nature in certain conditions raises concerns. The organism's ability to survive in various environments, including the gastrointestinal tract, suggests it may have mechanisms for immune evasion, although specific strategies are not well-documented. Antimicrobial Resistance: There is limited information regarding the antimicrobial resistance of Weissella cibaria. However, as with many lactic acid bacteria, it is generally susceptible to common antibiotics, which is beneficial for its use in probiotic formulations. Medical Applications: The potential use of Weissella cibaria as a probiotic is being explored, particularly in the context of oral health and gastrointestinal disorders. Its role in fermentation processes also makes it a candidate for use in food products aimed at enhancing gut health. Further research is needed to fully understand its therapeutic potential and mechanisms of action in the human body.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Weissella cibaria has shown significant potential in various industrial applications. One of the primary areas is in biotechnology, where Weissella cibaria is utilized in the fermentation process of food products, particularly in the production of fermented vegetables and dairy products. This organism contributes to the development of flavor and texture in products like kimchi and yogurt, enhancing their nutritional value and shelf life. In the realm of waste management, Weissella cibaria has been studied for its ability to degrade organic waste materials. Its enzymatic activity allows it to break down complex carbohydrates, making it a candidate for biodegradation processes that can help in the treatment of organic waste, thus reducing environmental impact. Furthermore, Weissella cibaria has potential applications in biofuel production. Its metabolic pathways can be harnessed to convert biomass into bioethanol through fermentation, providing a sustainable alternative to fossil fuels. This process not only contributes to energy production but also promotes the use of renewable resources. In pharmaceutical development, Weissella cibaria is being explored for its probiotic properties, which can enhance gut health and potentially lead to the development of new therapeutic products. Its ability to produce bioactive compounds may also have implications in the formulation of functional foods and nutraceuticals. Overall, Weissella cibaria demonstrates versatility across multiple industries, particularly in fermentation, biodegradation, and enzyme production, making it a valuable microorganism for future industrial applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	anthropic/claude-3.5-sonnet	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	google/gemma-7b-it	openai/gpt-4	openai/gpt-4	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	openai/gpt-4o	openai/gpt-4o	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain positive ✓
Aerophilicity	N/A	facultatively anaerobic	N/A	facultatively anaerobic	facultatively anaerobic	facultatively anaerobic	N/A	N/A	N/A	facultatively anaerobic	facultatively anaerobic	facultatively anaerobic	facultatively anaerobic	facultatively anaerobic	facultatively anaerobic	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	TRUE	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	false	false	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Host association	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	coccus ✗	coccus ✗	bacillus ✓	coccus ✗	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗

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