Kingella negevensis

General Information

Kingella negevensis is a relatively recent addition to the genus Kingella, which is part of the family Neisseriaceae. This microorganism is particularly interesting due to its unique genetic and phenotypic characteristics that distinguish it from other members of the genus. Discovered in the Negev desert, K. negevensis has adapted to survive in extreme environmental conditions, making it a valuable subject for studies on microbial resilience and adaptation. One of the most notable features of K. negevensis is its genomic composition, which provides insights into the evolutionary pathways of bacteria within the Neisseriaceae family. The genome of K. negevensis reveals a variety of genes that are involved in stress response mechanisms, which are crucial for its survival in harsh environments. This makes it an excellent model organism for studying the genetic basis of environmental adaptability. Additionally, K. negevensis has been found to possess unique metabolic pathways that allow it to utilize a range of substrates for growth. This metabolic versatility is of particular interest for biotechnological applications, such as bioremediation and the development of novel bio-based products. The organism's ability to thrive in nutrient-limited conditions also makes it a potential candidate for research in sustainable agriculture and soil health. From a clinical perspective, while K. negevensis is not currently known to be a major human pathogen, its close relation to other Kingella species, which are known to cause infections, warrants further investigation. Understanding the pathogenic potential and mechanisms of K. negevensis could provide valuable information for the development of new antimicrobial strategies. In summary, Kingella negevensis stands out due to its adaptation to extreme environments, genomic insights, and metabolic versatility, making it a microorganism of significant interest for both basic and applied research.

Kingella negevensis is a fascinating bacterium that was first isolated from human clinical specimens, particularly in cases of endocarditis and other infections. This organism is part of the Kingella genus, which is known for its association with human disease, particularly in immunocompromised individuals. One of the most interesting aspects of K. negevensis is its ability to thrive in various environments, suggesting a level of adaptability that is not fully understood yet. Unique Characteristics: K. negevensis is notable for its fastidious growth requirements, which makes it challenging to culture in laboratory settings. This characteristic can lead to underdiagnosis in clinical cases, highlighting the importance of awareness among healthcare professionals. The organism is also known to exhibit variable biochemical properties, which can complicate its identification and classification. Research Value: From a research perspective, K. negevensis presents an intriguing opportunity to study the mechanisms of bacterial pathogenesis, particularly in relation to its role in human infections. Understanding its virulence factors could provide insights into how it interacts with the host immune system. Additionally, the organism's unique growth requirements and biochemical variability make it a valuable subject for studies focused on microbial ecology and evolution. In summary, Kingella negevensis is a unique and valuable organism in the field of microbiology, with implications for both clinical diagnostics and fundamental research into bacterial behavior and pathogenicity.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Betaproteobacteria

Order: Neisseriales

Family: Neisseriaceae

Genus: Kingella

Species: Kingella negevensis

NCBI ID

1522312

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/030/177/895/GCF_030177895.1_ASM3017789v1

File for sequence-based predictions:
GCF_030177895.1_ASM3017789v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Kingella negevensis is a Gram-negative bacterium that has been associated with various clinical implications, particularly in immunocompromised individuals. It is known to be part of the normal flora of the human respiratory tract but can act as an opportunistic pathogen. Infections caused by K. negevensis are relatively rare but can lead to serious conditions such as endocarditis, osteomyelitis, and soft tissue infections. The bacterium has been documented in cases of bacteremia and septic arthritis, especially in patients with underlying health issues or those who have undergone invasive procedures. One of the notable aspects of K. negevensis is its potential for antimicrobial resistance. While it is generally susceptible to many antibiotics, there have been reports of resistance to certain classes, which complicates treatment options. This resistance can be attributed to various mechanisms, including the production of beta-lactamases and alterations in porin channels that limit drug entry. In terms of immune evasion, K. negevensis can manipulate host immune responses, allowing it to persist in the body despite the presence of an active immune system. This includes the ability to evade phagocytosis and modulate inflammatory responses, which can lead to chronic infections. Although K. negevensis is not commonly associated with large outbreaks, its role in localized infections highlights the importance of recognizing this organism in clinical settings, particularly in patients with compromised immune systems. Further research is needed to fully understand its pathogenic mechanisms and potential therapeutic applications.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Kingella negevensis is a bacterium that has been primarily isolated from the human oral cavity and respiratory tract. This organism is often associated with the microbiome of the mouth, where it plays a role in the complex interactions of oral flora. It thrives in environments that are rich in organic material and moisture, making the oral cavity an ideal habitat. In the context of its ecological niche, K. negevensis is known to engage in symbiotic relationships with other microorganisms, contributing to the overall health of the oral microbiome. It can help in the breakdown of organic compounds, thus playing a role in nutrient cycling within this biome. Additionally, K. negevensis has been linked to certain pathogenic conditions, indicating its potential role in disease processes when the balance of the oral microbiome is disrupted. This highlights its dual role as both a commensal and a potential pathogen, depending on the environmental conditions and host factors. Overall, the presence of Kingella negevensis in the oral cavity underscores the importance of microbial diversity in maintaining health and the delicate balance within this specific biome.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Kingella negevensis has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to participate in biodegradation, which is crucial for the breakdown of complex organic materials in waste treatment processes. By utilizing Kingella negevensis, industries can enhance the efficiency of waste treatment systems, leading to reduced environmental impact and improved waste management practices. In the realm of biofuel production, Kingella negevensis may contribute to the fermentation processes that convert organic substrates into biofuels. Its metabolic pathways can be harnessed to optimize the conversion of biomass into ethanol or other biofuels, making it a valuable asset in the pursuit of sustainable energy solutions. Furthermore, the enzymatic activities of Kingella negevensis can be explored for pharmaceutical development. The organism's unique enzymes may have applications in drug synthesis or the production of bioactive compounds, which can be pivotal in the development of new therapeutic agents. Overall, Kingella negevensis presents a promising opportunity for innovation across multiple industries, particularly through its roles in biodegradation, biofuel production, and enzyme production.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	anthropic/claude-3-haiku:beta	meta-llama/llama-3-8b-instruct:nitro	google/gemini-pro	mistralai/mixtral-8x7b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	google/gemma-7b-it	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4o	openai/gpt-4o	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro
Motility	FALSE	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	N/A	N/A	aerotolerant ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	N/A	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	beta	gamma ✗	alpha ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	beta ✓	beta ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

Back to Search