Brucella anthropi

General Information

Brucella anthropi is a fascinating microorganism that has garnered attention due to its unique characteristics and potential applications in various fields. This bacterium is part of the Brucella genus, which is primarily known for its pathogenic species that cause brucellosis in humans and animals. However, B. anthropi stands out as it is generally considered non-pathogenic and is often found in environmental samples such as soil and water, as well as in association with plants. One of the most intriguing aspects of B. anthropi is its ability to form symbiotic relationships with plants. This bacterium can colonize the rhizosphere, the region of soil surrounding plant roots, where it can promote plant growth by facilitating nutrient uptake and possibly producing growth-promoting substances. This makes B. anthropi a subject of interest in agricultural research, particularly in the development of biofertilizers and sustainable farming practices. Additionally, B. anthropi has been studied for its potential in bioremediation. Its presence in diverse environmental niches suggests that it may possess metabolic pathways capable of degrading various pollutants. This capability could be harnessed to clean up contaminated environments, making B. anthropi valuable in environmental biotechnology. From a clinical perspective, while B. anthropi is not typically associated with disease, it has been isolated from clinical specimens, particularly in immunocompromised patients. This highlights the importance of understanding its role in human health and disease, as well as its potential as an opportunistic pathogen. In summary, Brucella anthropi is a versatile and ecologically significant bacterium with potential applications in agriculture, environmental science, and medicine. Its ability to interact with plants and degrade pollutants, along with its occasional presence in clinical settings, makes it a compelling subject for ongoing research.

Brucella anthropi is a lesser-known member of the genus Brucella, which is primarily recognized for its role in zoonotic infections. This organism is particularly interesting due to its potential pathogenicity in humans, although it is not as widely studied as other species within the genus. B. anthropi has been isolated from various clinical specimens, suggesting that it may be an opportunistic pathogen, especially in immunocompromised individuals. One of the unique aspects of B. anthropi is its ability to survive in diverse environments, which may contribute to its persistence in clinical settings. This adaptability raises questions about its ecological niche and the mechanisms it employs to thrive in different conditions. From a research perspective, B. anthropi presents a valuable opportunity to explore the genetic and biochemical pathways that underlie its survival and pathogenicity. Understanding these mechanisms could provide insights into the broader Brucella genus and its interactions with host organisms. Furthermore, studying B. anthropi may help in developing better diagnostic tools and treatment strategies for infections caused by this and related species. Overall, while Brucella anthropi may not be as prominent as its relatives, its potential role in human health and its intriguing biological characteristics make it a noteworthy subject for further investigation.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Alphaproteobacteria

Order: Hyphomicrobiales

Family: Brucellaceae

Genus: Brucella

Species: Brucella anthropi

NCBI ID

529

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/015/326/295/GCA_015326295.1_ASM1532629v1

File for sequence-based predictions:
GCA_015326295.1_ASM1532629v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Brucella anthropi is a lesser-known member of the Brucella genus, primarily associated with zoonotic infections in humans. While it is not as commonly recognized as other Brucella species, it has been implicated in rare cases of human infections, particularly in immunocompromised individuals. The clinical implications of Brucella anthropi include its potential role in bacteremia and endocarditis, which can lead to serious health complications if not promptly diagnosed and treated. Pathogenicity is attributed to its ability to evade the immune response, allowing it to persist in the host. Furthermore, there is growing concern regarding antimicrobial resistance among Brucella species, including B. anthropi, which may complicate treatment options. The organism's resistance mechanisms can hinder effective therapy, making it crucial for healthcare providers to be aware of its potential presence in clinical settings. While Brucella anthropi does not have established medical applications such as probiotics or vaccines, its relevance in outbreaks and infections highlights the need for continued research and surveillance. Understanding its interactions with the human body and its strategies for immune evasion is essential for developing effective diagnostic and therapeutic approaches.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Brucella anthropi is primarily associated with human-associated environments and animal reservoirs, particularly in urban and agricultural settings. This microorganism is known to inhabit the gastrointestinal tracts of various mammals, including livestock, which serve as significant reservoirs for its transmission to humans. Its presence in these environments highlights its role in zoonotic diseases, where it can be transmitted from animals to humans, often through unpasteurized dairy products or direct contact with infected animals. In terms of ecological niches, Brucella anthropi thrives in warm, moist environments that facilitate its survival and reproduction. It is often found in soil and water contaminated with animal waste, where it can persist for extended periods. This adaptability allows it to exploit various habitats, contributing to its role in the ecosystem as both a pathogen and a participant in nutrient cycling. Notably, Brucella anthropi engages in symbiotic relationships with its hosts, where it can manipulate host immune responses to establish infection. This interaction underscores its significance in the microbial community and its impact on host health. Furthermore, its ability to survive in diverse environments demonstrates its ecological versatility, making it a subject of interest in studies related to infectious diseases and public health.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Brucella anthropi has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its role in biodegradation, where it can break down complex organic compounds, making it useful in the treatment of industrial waste. Its ability to metabolize various substrates allows it to be employed in waste treatment processes, effectively reducing the environmental impact of pollutants. In the realm of biotechnology, Brucella anthropi has been studied for its potential in enzyme production, particularly enzymes that can be utilized in various biochemical processes. These enzymes can facilitate reactions in the production of biofuels, contributing to the development of sustainable energy sources. The organism's metabolic pathways can be harnessed to optimize the fermentation processes involved in biofuel production, enhancing yield and efficiency. Moreover, Brucella anthropi has implications in pharmaceutical development, where its unique biochemical properties may lead to the discovery of novel compounds or therapeutic agents. Research into its metabolic capabilities could uncover new pathways for drug synthesis or the production of bioactive molecules. Overall, Brucella anthropi presents a promising avenue for innovation in waste management, biofuel production, and pharmaceutical development, showcasing its versatility and importance in industrial microbiology.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	google/gemini-flash-1.5	perplexity/llama-3-sonar-small-32k-chat	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	openchat/openchat-7b	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	TRUE	false ✗	true ✓	false ✗	true ✓	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain positive ✗	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain variable ✗	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain positive ✗	N/A	gram stain negative ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	false	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 3 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Spore formation	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	coccus ✗	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	coccus ✗	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	coccus ✗

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