Pandoraea apista

General Information

Pandoraea apista is a bacterium that belongs to the genus Pandoraea, which is known for its clinical significance, particularly in patients with cystic fibrosis. One of the most notable characteristics of P. apista is its association with respiratory infections. This organism has been isolated from sputum samples of cystic fibrosis patients, indicating its potential role in chronic lung infections. P. apista is interesting from a research perspective due to its antibiotic resistance profile. It exhibits resistance to multiple antibiotics, making infections difficult to treat and highlighting the need for novel therapeutic strategies. This resistance is partly due to the presence of various resistance genes, which can be studied to understand the mechanisms behind antibiotic resistance and to develop new antimicrobial agents. Another unique aspect of P. apista is its genomic adaptability. The genome of P. apista contains a variety of genes that allow it to survive in diverse environments, including the human respiratory tract. This adaptability is a subject of ongoing research, as understanding the genetic basis for its survival and pathogenicity could lead to better management of infections caused by this bacterium. In addition to its clinical relevance, P. apista is also of interest due to its metabolic versatility. It can utilize a wide range of substrates for growth, which makes it a potential candidate for biotechnological applications, such as bioremediation. The ability to degrade various compounds can be harnessed to clean up environmental pollutants, making P. apista valuable beyond its role as a pathogen. Overall, Pandoraea apista is a bacterium that stands out due to its clinical importance, antibiotic resistance, genomic adaptability, and metabolic versatility, making it a significant subject of study in both medical and environmental microbiology.*

Pandoraea apista is a notable member of the genus Pandoraea, which is recognized for its unique ecological niche and its significance in clinical microbiology. This bacterium was first isolated from a patient with cystic fibrosis, highlighting its association with chronic lung infections in individuals with this condition. What makes P. apista particularly interesting is its ability to thrive in environments that are often inhospitable to other microorganisms, showcasing its adaptability and resilience. One of the unique characteristics of Pandoraea apista is its metabolic versatility. It can utilize a variety of carbon sources, which allows it to survive in diverse environments, including soil and water, as well as in the human body. This metabolic flexibility is a subject of interest for researchers studying microbial ecology and the interactions between pathogens and their hosts. Furthermore, P. apista has been studied for its potential role in antibiotic resistance. It exhibits resistance to multiple antibiotics, which poses challenges in clinical settings, particularly for patients with compromised immune systems. Understanding the mechanisms behind this resistance is crucial for developing effective treatment strategies. In addition to its clinical implications, Pandoraea apista serves as a model organism for studying the evolution of bacterial species in response to environmental pressures. Its genome has been sequenced, providing insights into its genetic makeup and the evolutionary adaptations that allow it to persist in challenging conditions. This genomic information is invaluable for researchers exploring the genetic basis of pathogenicity and resistance in bacteria. Overall, Pandoraea apista stands out not only for its clinical relevance but also for its ecological and evolutionary significance, making it a valuable subject for ongoing research in microbiology and infectious diseases.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Betaproteobacteria

Order: Burkholderiales

Family: Burkholderiaceae

Genus: Pandoraea

Species: Pandoraea apista

NCBI ID

93218

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/465/595/GCF_001465595.2_ASM146559v2

File for sequence-based predictions:
GCF_001465595.2_ASM146559v2_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Pandoraea apista is a notable pathogen primarily associated with respiratory infections in individuals with compromised immune systems, particularly those with cystic fibrosis (CF). It has been isolated from the lungs of CF patients, where it can contribute to chronic lung infections and exacerbate pulmonary decline. The organism is known for its pathogenicity, which is attributed to its ability to form biofilms and its resistance to multiple antibiotics, making treatment challenging. This antimicrobial resistance is a significant concern, as Pandoraea apista exhibits resistance to common antibiotics such as aminoglycosides and beta-lactams, complicating therapeutic options. Furthermore, the organism's interaction with the human body involves evasion of the immune response, allowing it to persist in the respiratory tract. It has been implicated in various outbreaks within CF populations, highlighting its relevance in clinical settings. While research is ongoing, there is potential for exploring Pandoraea apista in the context of probiotics or other therapeutic applications, particularly in understanding its role in the microbiome of CF patients. Overall, the clinical implications of Pandoraea apista underscore the need for continued surveillance and research to better manage infections associated with this organism.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Pandoraea apista is a bacterium that is primarily associated with hospital environments and human-associated microbiomes. This organism is often isolated from clinical samples, particularly in patients with compromised immune systems or chronic lung diseases, such as cystic fibrosis. Its presence in these environments highlights its role in the human microbiome, where it can be part of the complex microbial community that influences health and disease outcomes. In terms of ecological niches, Pandoraea apista thrives in moist environments and is often found in biofilms on medical devices or in respiratory secretions. This bacterium exhibits opportunistic pathogenicity, meaning it can cause infections, particularly in vulnerable populations. Its ability to form biofilms allows it to adhere to surfaces and resist antimicrobial treatments, making it a significant concern in clinical settings. Additionally, Pandoraea apista has been noted for its potential symbiotic relationships with other microorganisms, contributing to the overall microbial diversity and functionality within its habitat. Its metabolic capabilities may also play a role in nutrient cycling within these environments, although specific interactions with other microbial species are still under investigation. Overall, the biomes associated with Pandoraea apista are characterized by their high humidity, nutrient availability, and the presence of other microbial inhabitants, which together create a complex ecosystem that can impact human health significantly.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Pandoraea apista has shown significant potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to thrive in diverse environments, which makes it a valuable asset in several processes. In biotechnology, Pandoraea apista is utilized in fermentation processes, where it can contribute to the production of bioactive compounds. Its metabolic pathways allow for the conversion of substrates into valuable products, which can be harnessed for various applications, including the development of novel pharmaceuticals. In the realm of waste management, Pandoraea apista has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic pollutants. This characteristic is crucial for the treatment of contaminated environments, as the organism can help in the detoxification of hazardous waste, thereby contributing to environmental sustainability. Furthermore, in pharmaceutical development, the enzymatic activities of Pandoraea apista are being explored for their potential in drug synthesis and modification. The organism's unique enzymatic profiles can facilitate the production of specific compounds that are essential in the formulation of therapeutic agents. Overall, Pandoraea apista represents a promising candidate for various industrial applications, particularly in processes that require efficient fermentation, biodegradation, and enzyme production.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro-1.5	perplexity/llama-3-sonar-small-32k-chat	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	openchat/openchat-7b	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	openai/gpt-4	openai/gpt-4	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4o	openai/gpt-4o	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	google/gemini-pro	google/gemini-pro	google/gemma-7b-it	google/gemma-7b-it
Motility	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain variable ✗	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain positive ✗	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	aerobic ✓	N/A	facultatively anaerobic ✗	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Animal pathogenicity	N/A	true	true	true	true	false	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	false	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Host association	N/A	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	false	false
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	beta	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

Back to Search