Achromobacter aegrifaciens

General Information

Achromobacter aegrifaciens is a bacterium that belongs to the genus Achromobacter, which is known for its diverse metabolic capabilities and environmental versatility. One of the key characteristics of A. aegrifaciens is its ability to degrade a wide range of organic compounds, making it particularly interesting for bioremediation applications. This organism can thrive in various environments, including soil and water, where it plays a role in breaking down pollutants and contributing to the natural recycling of organic matter. Another noteworthy feature of A. aegrifaciens is its potential in industrial biotechnology. Its enzymatic machinery is capable of catalyzing reactions that are valuable in the synthesis of fine chemicals and pharmaceuticals. Researchers are particularly interested in its enzymes for their stability and efficiency under different conditions, which can be harnessed for various biotechnological processes. From a clinical perspective, while Achromobacter species are not typically associated with human infections, they have been isolated from clinical settings, indicating their opportunistic pathogenic potential. This makes A. aegrifaciens a subject of interest in studying hospital-acquired infections and antibiotic resistance mechanisms. Overall, Achromobacter aegrifaciens stands out due to its metabolic diversity, environmental adaptability, and biotechnological potential, making it a valuable organism for both environmental and industrial research.

Achromobacter aegrifaciens is a fascinating bacterium that belongs to the genus Achromobacter, which is known for its diverse metabolic capabilities. This organism is particularly interesting due to its ability to thrive in various environments, including soil and water, making it a valuable subject for ecological and environmental studies. One of the standout features of A. aegrifaciens is its capacity to degrade a wide range of organic compounds, which positions it as a potential candidate for bioremediation efforts aimed at cleaning up contaminated environments. Additionally, A. aegrifaciens has been studied for its role in the human microbiome, where it may contribute to the complex interactions between microbial communities and host health. Its unique metabolic pathways allow it to utilize different carbon sources, which can provide insights into microbial adaptation and survival strategies in various ecological niches. Furthermore, research into A. aegrifaciens has implications for understanding antibiotic resistance mechanisms, as some strains exhibit resistance to multiple antibiotics. This characteristic makes it a significant organism in the study of public health and the development of new therapeutic strategies. Overall, Achromobacter aegrifaciens serves as an important model organism for exploring microbial ecology, bioremediation, and antibiotic resistance, highlighting its value in both environmental and medical research.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Betaproteobacteria

Order: Burkholderiales

Family: Alcaligenaceae

Genus: Achromobacter

Species: Achromobacter aegrifaciens

NCBI ID

1287736

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/030/845/255/GCF_030845255.1_ASM3084525v1

File for sequence-based predictions:
GCF_030845255.1_ASM3084525v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Achromobacter aegrifaciens is a member of the Achromobacter genus, which is known for its environmental presence and potential clinical significance. While it is not one of the most common pathogens, it has been associated with various infections in immunocompromised patients, particularly those with underlying conditions such as cystic fibrosis or chronic lung diseases. Clinical implications of A. aegrifaciens include its role in respiratory tract infections, where it can act as an opportunistic pathogen. This organism exhibits antimicrobial resistance, particularly to beta-lactam antibiotics, which complicates treatment options. The presence of resistance mechanisms, such as the production of beta-lactamases, underscores the need for careful antibiotic stewardship and susceptibility testing in clinical settings. In terms of immune evasion, A. aegrifaciens may utilize various strategies to survive within the host, including biofilm formation, which enhances its persistence in chronic infections. Although not widely recognized as a primary pathogen, A. aegrifaciens has been implicated in outbreaks, particularly in healthcare settings, where it can be transmitted through contaminated medical equipment or environments. Its detection in clinical specimens necessitates awareness among healthcare providers to ensure appropriate management and infection control measures. Overall, while Achromobacter aegrifaciens is not a leading cause of disease, its potential to cause infections in vulnerable populations and its associated antimicrobial resistance make it a relevant organism in clinical microbiology.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Achromobacter aegrifaciens is a bacterium commonly associated with various habitats and environments that reflect its ecological versatility. This microorganism is often found in soil and water environments, particularly in areas that are rich in organic matter. Its ability to thrive in these terrestrial and aquatic ecosystems highlights its role in nutrient cycling and organic decomposition. In soil ecosystems, A. aegrifaciens contributes to the breakdown of complex organic compounds, thus playing a crucial role in the decomposition process. This activity not only aids in nutrient availability for plants but also supports the overall health of the soil microbiome. The bacterium is known to engage in symbiotic relationships with various plant species, enhancing nutrient uptake and promoting plant growth. In aquatic environments, particularly in freshwater systems, A. aegrifaciens can be found in biofilms and sediment layers. Here, it participates in the biogeochemical cycling of nutrients, such as nitrogen and phosphorus, which are vital for maintaining the ecological balance of these habitats. Its presence in these environments can indicate the health of the ecosystem, as it often thrives in conditions where organic pollution is present, showcasing its potential as a bioremediator. Overall, Achromobacter aegrifaciens exemplifies the adaptability of microorganisms to various biomes, where it plays significant roles in nutrient cycling, decomposition, and symbiotic interactions with other organisms, thereby contributing to the stability and functionality of its ecosystems.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Achromobacter aegrifaciens has shown potential in various industrial applications, particularly in the fields of biotechnology, waste management, and pharmaceutical development. This organism is known for its ability to thrive in diverse environments, making it a candidate for several biotechnological processes. In biotechnology, Achromobacter aegrifaciens is utilized in fermentation processes, where it can be employed to produce valuable metabolites. Its metabolic pathways allow for the conversion of substrates into useful products, which can be harnessed in the production of bioactive compounds. In the realm of waste management, this microorganism has demonstrated capabilities in biodegradation, particularly in the breakdown of pollutants and organic waste. Its enzymatic activity enables it to degrade complex organic materials, making it useful in the treatment of wastewater and contaminated environments. This application is crucial for reducing environmental impact and promoting sustainability. Furthermore, in pharmaceutical development, Achromobacter aegrifaciens has been studied for its potential in producing novel antibiotics and other bioactive substances. Its unique metabolic properties may lead to the discovery of new therapeutic agents, contributing to the pharmaceutical industry’s efforts in combating resistant strains of bacteria. Overall, the versatility of Achromobacter aegrifaciens in these industrial applications highlights its significance in advancing biotechnological innovations and environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-flash-1.5	microsoft/phi-3-mini-128k-instruct	anthropic/claude-3.5-sonnet	anthropic/claude-3-haiku:beta	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-pro-1.5	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openchat/openchat-7b	openchat/openchat-7b	google/gemma-7b-it	google/gemma-7b-it	openai/gpt-4o	openai/gpt-4o	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	N/A	facultatively anaerobic ✗	aerobic ✓	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	true	false	true	true	false	true	true	false	false	false	true	true	true	true	false	false	false	false	true	true	false	false	true	true	false	false	false	false
Biosafety level	N/A	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2
Health association	N/A	true	false	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	false	false
Host association	TRUE	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	gamma	gamma ✓	N/A	N/A	alpha ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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