Dorea amylophila

General Information

Dorea amylophila is a fascinating microorganism primarily found in the human gut microbiota. This bacterium is part of the family Lachnospiraceae, which is known for its role in the digestion of complex carbohydrates. One of the most noteworthy characteristics of Dorea amylophila is its ability to break down starches, which is reflected in its name, with 'amylophila' indicating a love for starch. This capability makes it an important player in the fermentation processes within the gut, contributing to the production of short-chain fatty acids (SCFAs) such as butyrate, which are crucial for colon health. Another unique aspect of Dorea amylophila is its potential role in modulating the immune system. Research has suggested that the metabolites produced by this bacterium can influence the host's immune responses, potentially offering protective effects against certain inflammatory conditions. This makes Dorea amylophila a subject of interest in studies exploring the gut-brain axis and its implications for mental health and neurological disorders. From a research perspective, Dorea amylophila is valuable due to its genomic insights. The genome of this bacterium has been sequenced, providing a wealth of information about its metabolic pathways and interactions with other gut microbes. This genomic data is instrumental in understanding how Dorea amylophila contributes to the overall functionality and stability of the gut microbiome. In summary, Dorea amylophila stands out for its starch-degrading abilities, its potential immunomodulatory effects, and its genomic contributions to microbiome research. These characteristics make it a significant organism for studies focused on gut health, metabolic processes, and the intricate relationships within the human microbiome.

Dorea amylophila is a fascinating member of the Firmicutes phylum, primarily known for its role in the human gut microbiome. This anaerobic bacterium is particularly interesting due to its ability to ferment complex carbohydrates, especially starches, which makes it a significant player in the digestion of dietary fibers. Its name, which translates to 'starch-loving', reflects its unique metabolic capabilities that allow it to thrive in environments rich in polysaccharides. One of the most valuable aspects of Dorea amylophila is its potential contribution to gut health. By breaking down starches, it produces short-chain fatty acids (SCFAs) such as butyrate, which are known to have numerous health benefits, including anti-inflammatory properties and serving as an energy source for colonocytes. This metabolic activity positions Dorea amylophila as a key organism in the maintenance of gut homeostasis and overall health. Moreover, research into Dorea amylophila can provide insights into the interactions within the gut microbiome. Its presence and abundance can influence the composition of other microbial communities, making it a subject of interest in studies related to dysbiosis and various gastrointestinal disorders. Understanding how Dorea amylophila interacts with other gut microbes could lead to novel therapeutic strategies for managing conditions such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). In summary, Dorea amylophila stands out not only for its unique carbohydrate fermentation capabilities but also for its potential implications in human health and disease, making it a valuable organism for ongoing microbiological and biomedical research.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Clostridia

Order: Lachnospirales

Family: Lachnospiraceae

Genus: Dorea

Species: Dorea amylophila

NCBI ID

2981789

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/027/664/025/GCF_027664025.1_ASM2766402v1

File for sequence-based predictions:
GCF_027664025.1_ASM2766402v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Dorea amylophila is a member of the human gut microbiota and has been studied for its potential role in human health and disease. It is primarily known for its ability to ferment carbohydrates, particularly starches, which can influence gut health and metabolism. Research indicates that Dorea amylophila may be associated with improved metabolic profiles, including lower levels of inflammatory markers and better glycemic control in certain populations. However, the clinical implications of Dorea amylophila are not entirely understood, and its role in disease associations remains an area of ongoing research. Some studies suggest that alterations in the abundance of this organism may correlate with conditions such as obesity and type 2 diabetes, indicating a potential link between gut microbiota composition and metabolic disorders. In terms of pathogenicity, Dorea amylophila is generally considered non-pathogenic and is not typically associated with infections in healthy individuals. However, its presence in the gut may be affected by various factors, including diet and antibiotic use, which can lead to shifts in microbial populations. Regarding antimicrobial resistance, there is limited data on Dorea amylophila specifically; however, the gut microbiome as a whole is known to harbor resistance genes that can be transferred among different bacterial species. This highlights the importance of understanding the dynamics of gut microbiota in the context of antibiotic treatment and resistance development. Overall, while Dorea amylophila shows promise in contributing to human health through its metabolic functions, further research is needed to fully elucidate its clinical relevance and potential applications in therapeutics or as a probiotic.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Dorea amylophila is a member of the gut microbiota, primarily found in the human gastrointestinal tract. This microorganism thrives in the anaerobic environment of the colon, where it plays a significant role in the fermentation of dietary fibers and resistant starches. Its ability to break down complex carbohydrates contributes to the production of short-chain fatty acids (SCFAs), which are crucial for maintaining gut health and providing energy to colonocytes. In addition to its role in fermentation, Dorea amylophila is known for its symbiotic relationships with other gut bacteria. It often coexists with species that produce SCFAs, enhancing the overall metabolic capacity of the gut microbiome. This interaction is vital for the maintenance of gut homeostasis and can influence the host's immune response. Furthermore, Dorea amylophila has been associated with the health of the host, as a balanced population of this microorganism can help prevent dysbiosis, which is linked to various gastrointestinal disorders. Its presence is often noted in individuals consuming a diet rich in fibers, indicating its adaptation to environments where complex carbohydrates are abundant. Overall, Dorea amylophila exemplifies the intricate relationships within the gut ecosystem, highlighting its importance in nutrient metabolism and the overall health of the host organism.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Dorea amylophila has shown significant potential in various industrial applications, particularly in the fields of biotechnology, waste management, and biofuel production. This organism is known for its ability to ferment carbohydrates, making it a valuable asset in fermentation processes. In the production of biofuels, Dorea amylophila can effectively convert starches and other polysaccharides into fermentable sugars, which can then be transformed into ethanol or other biofuels. This process not only contributes to renewable energy sources but also aids in reducing reliance on fossil fuels. In the realm of waste management, Dorea amylophila plays a crucial role in the biodegradation of organic waste. Its enzymatic activity allows it to break down complex organic materials, facilitating the biodegradation process and enhancing the efficiency of waste treatment systems. This capability is particularly beneficial in anaerobic digestion, where the microorganism can help in the stabilization of organic waste and the production of biogas, a renewable energy source. Furthermore, the potential of Dorea amylophila in pharmaceutical development is being explored, particularly in the synthesis of bioactive compounds through its metabolic pathways. The organism's ability to produce specific enzymes can be harnessed for the development of novel pharmaceuticals, contributing to advancements in drug formulation and therapeutic applications. Overall, Dorea amylophila exemplifies the versatility of microorganisms in addressing industrial challenges and promoting sustainable practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	openchat/openchat-7b	meta-llama/llama-3-8b-instruct:nitro	google/gemini-pro	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	google/gemma-7b-it	mistralai/mistral-7b-instruct	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-flash-1.5	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	perplexity/llama-3-sonar-small-32k-chat	openai/gpt-4o	openai/gpt-4o
Motility	N/A	false	false	false	true	false	true	false	true	true	false	true	true	true	true	false	false	false	false	false	false	true	true	true	true	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain negative ✗	gram stain variable ✗	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓
Aerophilicity	anaerobic	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	TRUE	false ✗	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Biofilm formation	N/A	false	true	false	true	true	true	true	true	false	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	false	false
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	true	true	true	true	true	false	true	true	false	false	false	false	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	coccus	bacillus	bacillus	bacillus	bacillus	bacillus	coccus	bacillus	bacillus	bacillus	spirillum	spirillum	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus

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