Streptomyces griseorubens

General Information

Streptomyces griseorubens is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. griseorubens is its ability to produce a wide array of antibiotics, making it a valuable organism in pharmaceutical research and biotechnology. This species is particularly interesting due to its complex life cycle, which includes the formation of a mycelium and the production of spores, although the latter is not the focus here. Streptomyces species, including S. griseorubens, are known for their soil-dwelling nature and their role in decomposing organic matter, contributing to nutrient cycling in ecosystems. The metabolic versatility of S. griseorubens allows it to degrade a variety of complex organic compounds, which is of significant interest for environmental bioremediation efforts. Another unique aspect of S. griseorubens is its genetic and biochemical diversity. The genome of S. griseorubens harbors numerous gene clusters responsible for the biosynthesis of secondary metabolites, including antibiotics, antifungals, and other bioactive compounds. This genetic potential makes it a target for genetic and metabolic engineering to discover and produce new drugs. In summary, Streptomyces griseorubens stands out due to its antibiotic production capabilities, environmental significance, and genetic diversity, making it a valuable organism for both scientific research and practical applications in medicine and environmental management.

Streptomyces griseorubens is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, making it a valuable organism in pharmaceutical research. This species is particularly interesting due to its capacity to synthesize antibiotics, which are crucial in the fight against bacterial infections. The metabolites produced by S. griseorubens have been shown to exhibit significant antimicrobial activity, highlighting its potential as a source for new therapeutic agents. One of the unique aspects of S. griseorubens is its ability to thrive in diverse environments, which contributes to its genetic diversity and the potential for discovering novel compounds. The organism is also known for its complex life cycle, which includes the formation of aerial hyphae and spores, allowing it to adapt to various ecological niches. Moreover, S. griseorubens has been studied for its role in soil health and nutrient cycling, as it contributes to the degradation of organic matter and the production of humic substances. This ecological function underscores its importance in sustainable agriculture and environmental management. In summary, Streptomyces griseorubens stands out not only for its antibiotic production but also for its ecological significance and potential applications in biotechnology, making it a subject of ongoing research interest.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces griseorubens

NCBI ID

66897

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/709/915/GCA_000709915.1_JSD

File for sequence-based predictions:
GCA_000709915.1_JSD_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces griseorubens is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. This species has been studied for its potential in antimicrobial therapy, particularly due to its ability to produce various secondary metabolites that exhibit antibacterial and antifungal properties. The clinical implications of Streptomyces griseorubens are particularly relevant in the context of drug resistance, as it may offer alternative sources of antibiotics against resistant strains of bacteria. In addition to its therapeutic potential, Streptomyces griseorubens has been investigated for its role in human health through its possible applications in probiotics and bioremediation. Its interaction with the human microbiome may contribute to maintaining a balanced microbial community, which is essential for overall health. However, the pathogenicity of Streptomyces griseorubens is not well-documented, and it is generally considered non-pathogenic. Nonetheless, its ability to produce various enzymes and metabolites raises questions about its immune evasion strategies and potential interactions with the human immune system. Overall, while Streptomyces griseorubens is primarily recognized for its beneficial applications in medicine, ongoing research is necessary to fully understand its implications in human health, disease associations, and its potential role in future therapeutic developments.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces griseorubens is a species of bacterium that is primarily found in soil ecosystems, particularly in terrestrial environments rich in organic matter. This microorganism thrives in nutrient-dense habitats where it plays a crucial role in the decomposition of organic materials, contributing to nutrient cycling and soil health. Its ability to produce a variety of bioactive compounds makes it significant in the soil microbiome, where it interacts with other microorganisms and plants, often promoting plant growth through mechanisms such as antibiotic production and mycorrhizal associations. In addition to its role in nutrient cycling, Streptomyces griseorubens is known for its symbiotic relationships with various plants, enhancing their resistance to pathogens and improving overall plant health. This bacterium can also adapt to varying pH levels and moisture conditions, allowing it to thrive in diverse soil types, from sandy to clay-rich soils. Its presence is often indicative of a healthy ecosystem, as it contributes to the biodiversity and stability of the soil community. Overall, Streptomyces griseorubens exemplifies the intricate relationships within terrestrial biomes, showcasing the importance of microbial life in maintaining ecological balance and supporting plant growth.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces griseorubens is known for its significant contributions to various industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and waste management. This actinobacterium is renowned for its ability to produce a wide range of bioactive compounds, including antibiotics and enzymes, which are crucial in the pharmaceutical industry. For instance, it has been documented to produce compounds that exhibit antimicrobial properties, making it a valuable resource in the development of new antibiotics through fermentation processes. In the realm of biotechnology, Streptomyces griseorubens is utilized for its enzymatic activities, particularly in the production of enzymes that can be applied in various industrial processes. These enzymes can facilitate biodegradation of complex organic materials, thus playing a role in waste management by breaking down pollutants and organic waste in a more environmentally friendly manner. Moreover, the potential of Streptomyces griseorubens in biofuel production is being explored, as certain strains have shown the ability to degrade lignocellulosic biomass, which is a critical step in the conversion of plant materials into biofuels. This process often involves fermentation to convert sugars released from biomass into ethanol or other biofuels. Overall, Streptomyces griseorubens exemplifies the versatility of microorganisms in industrial applications, particularly through its roles in fermentation, enzyme production, and biodegradation, making it a key player in sustainable practices across multiple industries.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/gemini-flash-1.5	google/gemini-flash-1.5	google/gemini-pro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	N/A	false	false	false	false	false	true	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false
Gram staining	gram stain positive	gram stain positive ✓	N/A	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	false	false	true	true	true	true	true	false	false	false	true	true	false	false	true	true	false	false	true	true	true	true	true	true	true	true	true	true
Host association	FALSE	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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