Streptomyces aureocirculatus

General Information

Streptomyces aureocirculatus is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. aureocirculatus is its ability to produce a variety of bioactive compounds, including antibiotics, antifungals, and antitumor agents. This makes it a valuable subject of study in pharmaceutical research and biotechnology. Streptomyces species are known for their complex life cycle, which includes the formation of a mycelium and spore chains, contributing to their unique colony morphology. S. aureocirculatus typically forms well-developed, branched mycelia that can be observed under a microscope, providing a visually striking example of bacterial differentiation. Another interesting aspect of S. aureocirculatus is its ecological role. It is commonly found in soil, where it plays a crucial part in the decomposition of organic matter and the cycling of nutrients. This organism's ability to degrade complex polymers such as cellulose and chitin highlights its importance in maintaining soil health and fertility. From a genetic perspective, S. aureocirculatus possesses a large and complex genome, which encodes a vast array of enzymes and regulatory proteins. This genetic diversity underpins its metabolic versatility and capacity to produce a wide range of secondary metabolites. Researchers are particularly interested in the biosynthetic gene clusters within its genome, which are responsible for the synthesis of its bioactive compounds. In summary, Streptomyces aureocirculatus is a microorganism of significant interest due to its prolific production of bioactive compounds, its complex life cycle and morphology, and its important ecological role in soil environments. Its genetic and metabolic capabilities continue to be a rich area of research, with potential applications in medicine, agriculture, and environmental science.

Streptomyces aureocirculatus is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, making it a valuable organism in pharmaceutical research. This species is particularly interesting due to its capacity to synthesize antibiotics, which are crucial in the fight against bacterial infections. The unique metabolic pathways of S. aureocirculatus allow it to generate compounds that exhibit antimicrobial, antifungal, and antitumor activities. One of the standout features of S. aureocirculatus is its ability to produce golden-yellow pigments, which not only contribute to its name but also have potential applications in the development of natural dyes and pigments in various industries. These pigments are of interest for their potential antioxidant properties, which could be harnessed in food preservation and cosmetics. Additionally, S. aureocirculatus has been studied for its role in soil health and plant growth promotion. Its presence in the soil can enhance nutrient availability and improve plant resilience against pathogens, making it a key player in sustainable agriculture practices. The organism's ability to degrade complex organic materials also positions it as a potential agent for bioremediation, helping to clean up contaminated environments. Overall, Streptomyces aureocirculatus stands out not only for its diverse metabolic capabilities but also for its contributions to medicine, agriculture, and environmental science, making it a subject of ongoing research and interest.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces aureocirculatus

NCBI ID

67275

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/725/745/GCA_000725745.1_Doro.v1.0

File for sequence-based predictions:
GCA_000725745.1_Doro.v1.0_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces aureocirculatus is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. While S. aureocirculatus itself is not commonly associated with human disease, its relatives have been implicated in various infections and have shown potential for pathogenicity under certain conditions. Clinical relevance arises primarily from its ability to produce secondary metabolites that can be harnessed for therapeutic purposes, including the development of new antibiotics to combat antimicrobial resistance (AMR). In the context of human health, the metabolites produced by S. aureocirculatus may have applications in the treatment of bacterial infections, particularly those caused by resistant strains. The organism's interaction with the human microbiome is an area of interest, as some Streptomyces species are known to contribute positively to gut health and may act as probiotics. However, the potential for immune evasion strategies and the risk of opportunistic infections in immunocompromised individuals cannot be overlooked, as some Streptomyces species have been documented in rare cases of infections in humans. Overall, while S. aureocirculatus may not be a primary pathogen, its contributions to antibiotic production and potential therapeutic applications underscore its importance in the medical field.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces aureocirculatus is a species of actinobacteria commonly found in various terrestrial environments, particularly in soil and decaying organic matter. This microorganism thrives in nutrient-rich habitats where it plays a crucial role in the decomposition process, contributing to nutrient cycling and soil health. Its ability to produce a wide range of bioactive compounds makes it significant in the soil microbiome, where it interacts with other microorganisms and plants. Ecological Niches: - _Streptomyces aureocirculatus occupies a niche as a decomposer, breaking down complex organic materials and facilitating the release of nutrients back into the ecosystem. This process is vital for maintaining soil fertility and supporting plant growth. - It is often found in association with roots of various plants, where it can engage in symbiotic relationships that enhance nutrient uptake for the host plant while benefiting from organic compounds exuded by the roots. Habitats: - This organism is predominantly located in temperate and tropical soils, where conditions such as moisture, pH, and organic matter content are favorable for its growth. It can also be isolated from compost piles and forest litter, where it contributes to the breakdown of organic materials. Environmental Adaptation: - Streptomyces aureocirculatus exhibits remarkable adaptability to varying environmental conditions, including changes in moisture and nutrient availability. Its ability to produce spores allows it to survive in harsh conditions, ensuring its persistence in the ecosystem. In summary, Streptomyces aureocirculatus is an essential component of the soil ecosystem, playing a significant role in decomposition, nutrient cycling, and plant health through its various interactions within its habitat.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces aureocirculatus is known for its significant contributions to various industrial applications. One of the primary areas of interest is in biotechnology, where this organism is utilized for its ability to produce a wide range of bioactive compounds, including antibiotics and enzymes. The fermentation process employed by Streptomyces aureocirculatus allows for the large-scale production of these valuable metabolites, which are essential in pharmaceutical development for treating infections and diseases. In the realm of waste management, Streptomyces aureocirculatus has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic materials. This property is beneficial for the treatment of industrial waste, as it can help in the detoxification and reduction of harmful pollutants in the environment. Moreover, the organism's enzymatic activity is noteworthy, as it produces various enzymes that can be harnessed in biofuel production. These enzymes facilitate the conversion of biomass into fermentable sugars, which can then be transformed into biofuels through subsequent fermentation processes. This application is particularly relevant in the context of renewable energy, where sustainable practices are increasingly prioritized. Overall, Streptomyces aureocirculatus showcases a versatile profile with its involvement in pharmaceutical development, biotechnology, waste management, and biofuel production, making it a valuable microorganism in multiple industrial sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-4o	openai/gpt-4o	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	google/gemini-pro	google/gemini-pro
Motility	N/A	false	false	false	false	false	true	true	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	false	true	true	false	true	true	false	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	FALSE	true ✗	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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