Kitasatospora misakiensis

General Information

Kitasatospora misakiensis is a fascinating microorganism belonging to the genus Kitasatospora, which is known for its prolific production of bioactive compounds. One of the most noteworthy characteristics of Kitasatospora misakiensis is its ability to produce antibiotics and other secondary metabolites that have significant pharmaceutical applications. This makes it a valuable organism for drug discovery and development. The genus Kitasatospora is closely related to Streptomyces, another well-known genus famous for its antibiotic production. However, Kitasatospora misakiensis stands out due to its unique metabolic pathways and the distinct set of bioactive compounds it can synthesize. Researchers are particularly interested in this species because it has been found to produce misakinolides, which are compounds with potential antitumor and antifungal properties. Another intriguing aspect of Kitasatospora misakiensis is its complex life cycle, which includes the formation of mycelium and spores, similar to fungi. This complex differentiation process is of great interest to microbiologists studying bacterial development and differentiation. In addition to its pharmaceutical potential, Kitasatospora misakiensis is also studied for its role in soil ecology. It contributes to the decomposition of organic matter and the cycling of nutrients, playing a crucial role in maintaining soil health. Overall, Kitasatospora misakiensis is a microorganism of significant interest due to its biotechnological applications, unique metabolic capabilities, and ecological importance. Its ability to produce novel bioactive compounds continues to make it a valuable subject of research in various scientific fields.

Kitasatospora misakiensis is a fascinating actinobacterium that has garnered attention due to its unique biosynthetic capabilities. This microorganism is particularly notable for its ability to produce a variety of bioactive secondary metabolites, which have significant implications in pharmaceutical research. One of the most interesting aspects of Kitasatospora misakiensis is its potential to yield novel antibiotics and other therapeutic compounds, making it a valuable organism in the search for new drugs to combat resistant bacterial strains. The species was first isolated from soil samples in Japan, specifically from the Misaki area, which contributes to its name. Its ecological niche suggests that it plays a crucial role in the soil microbiome, participating in nutrient cycling and possibly influencing plant health through its interactions with other soil microorganisms. In addition to its antibiotic production, Kitasatospora misakiensis has been studied for its unique metabolic pathways, which can lead to the synthesis of compounds with diverse biological activities. This metabolic versatility makes it a prime candidate for biotechnological applications, including the development of new agricultural biopesticides and growth promoters. Furthermore, the genomic analysis of Kitasatospora misakiensis has revealed a rich repertoire of biosynthetic gene clusters, indicating its potential for producing a wide array of natural products. This genomic insight not only enhances our understanding of its metabolic capabilities but also opens avenues for genetic engineering and synthetic biology applications aimed at optimizing the production of valuable compounds. Overall, Kitasatospora misakiensis stands out as a significant organism in microbiological research, with its promising applications in medicine and agriculture, making it a subject of ongoing scientific interest.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Kitasatospora

Species: Kitasatospora misakiensis

NCBI ID

67330

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/715/585/GCA_000715585.2_ASM71558v2

File for sequence-based predictions:
GCA_000715585.2_ASM71558v2_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The actinobacterium Kitasatospora misakiensis is known for its antibiotic-producing capabilities, which have significant implications in the field of medicine. This organism is part of the diverse group of soil-dwelling actinobacteria that contribute to the natural production of antibiotics, making it a potential source for new antimicrobial agents. Its metabolites have been studied for their antimicrobial properties, particularly against various bacterial pathogens, which is crucial in the ongoing battle against antimicrobial resistance. In terms of pathogenicity, Kitasatospora misakiensis is not typically associated with human infections; however, its close relatives within the genus may exhibit pathogenic traits. The organism's role in human health is primarily linked to its potential use in developing new therapeutic agents rather than causing disease. The ability of Kitasatospora misakiensis to produce bioactive compounds can be harnessed in the development of probiotics or as a model for studying immune response mechanisms in the human body. Furthermore, the exploration of Kitasatospora misakiensis in biotechnological applications highlights its relevance in the production of novel drugs. Its interaction with the human microbiome and potential benefits in maintaining gut health are areas of ongoing research. Overall, while Kitasatospora misakiensis is not directly linked to human disease, its contributions to antibiotic discovery and potential therapeutic applications underscore its importance in clinical microbiology.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Kitasatospora misakiensis is a species of actinobacteria that is primarily found in soil and marine environments. This microorganism thrives in nutrient-rich substrates, often associated with decaying organic matter, which provides a suitable habitat for its growth and metabolic activities. Its presence is particularly noted in terrestrial ecosystems where it plays a crucial role in the decomposition process, contributing to nutrient cycling and soil health. In marine biomes, Kitasatospora misakiensis has been isolated from sediment samples, indicating its adaptability to saline conditions. This organism is known for its ability to produce various bioactive compounds, which can have significant ecological implications, including antimicrobial properties that may influence microbial community dynamics. Notably, Kitasatospora misakiensis engages in symbiotic relationships with plants, enhancing nutrient uptake and promoting plant growth through the production of growth-promoting substances. This interaction underscores its importance in agricultural ecosystems, where it can be utilized as a biofertilizer to improve soil fertility and crop yields. Overall, Kitasatospora misakiensis exemplifies the intricate connections within ecosystems, showcasing its role in both decomposition and plant-microbe interactions, which are vital for maintaining ecological balance and promoting biodiversity.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Kitasatospora misakiensis has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is utilized for its ability to produce a range of bioactive compounds, including antibiotics and other pharmaceuticals. This capability is particularly valuable in the development of new drugs, as Kitasatospora misakiensis can be harnessed in fermentation processes to yield these compounds efficiently. In the realm of waste management, Kitasatospora misakiensis has demonstrated effectiveness in biodegradation processes, where it can break down complex organic materials, thus aiding in the treatment of waste and reducing environmental pollution. This characteristic makes it a candidate for use in bioremediation strategies, where it can help detoxify contaminated environments. Furthermore, the organism has potential in biofuel production. Its metabolic pathways can be exploited to convert biomass into biofuels through fermentation, contributing to sustainable energy solutions. The ability to utilize various substrates for fermentation enhances its applicability in this sector. In summary, Kitasatospora misakiensis is a versatile microorganism with promising applications in pharmaceutical development, waste management, and biofuel production, primarily through its roles in fermentation and biodegradation processes.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3.5-sonnet	google/gemini-pro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openchat/openchat-7b	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro
Motility	N/A	false	false	false	false	false	true	false	false	false	false	false	false	true	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	true	true	true	false	false	true	true	false	false	false	false	true	true	true	true	false	false	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	false	true	true	true	true	false	false	false	false	false	false	true	true	true	true	false	false	false	false	false	false	false	false	false	false	false	false
Host association	FALSE	true ✗	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	coccus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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