Streptomyces umbrinus

General Information

Streptomyces umbrinus is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. These metabolites include a wide array of antibiotics, making Streptomyces species invaluable in the field of medical microbiology and pharmaceutical research. One of the most notable characteristics of S. umbrinus is its ability to produce bioactive compounds that have potential therapeutic applications. This includes antimicrobial, antifungal, and anticancer properties, which are of significant interest for developing new treatments for various diseases. Streptomyces umbrinus is also known for its complex life cycle, which involves the formation of a mycelium and the production of spores. This life cycle is not only intriguing from a biological standpoint but also offers insights into the mechanisms of differentiation and development in bacteria. The organism's ability to degrade a variety of organic materials makes it an important player in soil ecosystems, contributing to nutrient cycling and soil health. Another unique aspect of S. umbrinus is its genetic and metabolic diversity. The genome of Streptomyces species is typically large and rich in genes responsible for the biosynthesis of secondary metabolites. This genetic wealth provides a treasure trove for biotechnological exploitation, including the discovery of novel drugs and industrial enzymes. In summary, Streptomyces umbrinus stands out due to its prolific production of bioactive compounds, complex life cycle, and genetic diversity, making it a microorganism of great interest in both ecological and biotechnological research.

Streptomyces umbrinus is a fascinating actinobacterium known for its remarkable ability to produce a diverse array of bioactive compounds, including antibiotics and antifungal agents. This species is part of the larger genus Streptomyces, which is renowned for its role in natural product biosynthesis. One of the most interesting aspects of S. umbrinus is its capacity to thrive in soil environments, where it plays a crucial role in the decomposition of organic matter, contributing to nutrient cycling and soil health. Unique Metabolite Production: Streptomyces umbrinus is particularly noted for its production of unique secondary metabolites that have potential applications in pharmaceuticals. These compounds are of great interest to researchers looking to discover new drugs, especially in the fight against antibiotic-resistant bacteria. The metabolic pathways involved in the synthesis of these compounds are a subject of ongoing research, providing insights into microbial biosynthesis and genetic regulation. Ecological Importance: Beyond its pharmaceutical potential, S. umbrinus contributes significantly to its ecosystem. By breaking down complex organic materials, it helps maintain soil fertility and supports plant growth. This ecological role makes it a valuable organism for studies in environmental microbiology and sustainable agriculture. Genomic Insights: The genome of Streptomyces umbrinus has been sequenced, revealing a wealth of information about its genetic makeup and the biosynthetic gene clusters responsible for its unique metabolites. This genomic data is invaluable for biotechnological applications, allowing scientists to manipulate these pathways for enhanced production of desired compounds. In summary, Streptomyces umbrinus stands out not only for its ecological contributions but also for its potential in drug discovery and biotechnological innovations, making it a significant subject of study in microbiology and pharmacology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces umbrinus

NCBI ID

67370

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/014/656/275/GCA_014656275.1_ASM1465627v1

File for sequence-based predictions:
GCA_014656275.1_ASM1465627v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces umbrinus is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. While S. umbrinus itself is not commonly associated with human disease, its relatives have been implicated in various clinical contexts. Antibiotic production is one of the most notable aspects of this genus, with many species contributing to the development of clinically relevant antibiotics such as streptomycin and tetracycline. This highlights the potential of S. umbrinus in therapeutics and the pharmaceutical industry. In terms of pathogenicity, members of the Streptomyces genus are generally considered non-pathogenic to humans; however, they can occasionally be involved in opportunistic infections, particularly in immunocompromised individuals. The ability of some Streptomyces species to produce a variety of secondary metabolites may also contribute to their role in immune evasion, although specific mechanisms for S. umbrinus are not well-documented. Furthermore, the potential for antimicrobial resistance is a critical area of study, as the overuse of antibiotics derived from Streptomyces can lead to the emergence of resistant strains. Understanding the resistance mechanisms in this genus is essential for developing effective treatment strategies. In summary, while Streptomyces umbrinus may not have direct clinical implications as a pathogen, its contributions to antibiotic production and the broader implications of its relatives in human health and disease make it a significant organism in microbiological and pharmaceutical research.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces umbrinus is a species of actinobacteria commonly found in soil and decaying organic matter. This microorganism thrives in a variety of terrestrial biomes, particularly in temperate forests and grasslands, where it plays a crucial role in the decomposition of organic materials. Its ability to break down complex organic compounds contributes significantly to nutrient cycling within these ecosystems. In its natural habitat, Streptomyces umbrinus engages in symbiotic relationships with plants, promoting plant health by enhancing nutrient availability through the breakdown of organic matter. This interaction is particularly important in nutrient-poor soils, where the presence of this bacterium can improve soil fertility and support plant growth. Additionally, Streptomyces umbrinus is known for its production of antibiotics and other bioactive compounds, which can inhibit the growth of competing microorganisms. This characteristic not only aids in its survival but also influences the microbial community structure in its environment, showcasing its role as a keystone species in maintaining ecological balance. Overall, the ecological niche of Streptomyces umbrinus is characterized by its adaptability to various soil types and its significant contributions to nutrient cycling, plant health, and microbial diversity in the ecosystems it inhabits.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces umbrinus is known for its significant contributions to various industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and waste management. This actinobacterium is renowned for its ability to produce a wide range of bioactive compounds, including antibiotics, which are crucial in the development of new medications. Its role in fermentation processes allows for the production of these valuable metabolites, making it a key player in the pharmaceutical industry. In addition to its pharmaceutical applications, Streptomyces umbrinus has demonstrated potential in biodegradation processes, particularly in the breakdown of complex organic materials. This capability is particularly useful in waste treatment facilities, where the organism can help in the degradation of pollutants and organic waste, thereby contributing to environmental sustainability. Moreover, the enzymatic activities of Streptomyces umbrinus are being explored for their potential in biofuel production. The enzymes produced by this microorganism can facilitate the conversion of biomass into fermentable sugars, which can then be utilized in the production of biofuels. This process not only aids in renewable energy production but also promotes the efficient use of waste materials. Overall, Streptomyces umbrinus exemplifies the versatility of microorganisms in industrial applications, showcasing its importance in fermentation, biodegradation, and enzyme production, thereby contributing to advancements in biotechnology and environmental management.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3.5-sonnet	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	google/gemini-pro	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	openai/gpt-4	openai/gpt-4	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	N/A	false	false	false	false	false	false	true	true	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	false	true	true	false	true	true	true	true	false	false	false	false	false	true	true	true	true	false	false	false	false	true	true	false	false
Host association	FALSE	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	spirillum ✗	spirillum ✗

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