Streptomyces luteogriseus

General Information

Streptomyces luteogriseus is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. luteogriseus is its ability to produce a wide array of antibiotics and bioactive compounds. This makes it a valuable organism in the field of biotechnology and pharmaceutical research. Streptomyces species are known for their complex life cycle and filamentous growth, which is reminiscent of fungal mycelia. This unique growth pattern allows them to thrive in soil environments, where they play a crucial role in decomposing organic matter and contributing to soil health. The production of secondary metabolites by S. luteogriseus includes not only antibiotics but also antifungal agents, antitumor compounds, and immunosuppressants. These compounds have significant therapeutic potential and are the subject of extensive research for drug development. Moreover, S. luteogriseus exhibits a distinctive pigmentation, often producing yellow to grayish hues, which can be a useful phenotypic marker in laboratory settings. The organism's ability to produce pigments is also of interest for potential applications in natural dye production. In summary, Streptomyces luteogriseus is a microorganism of great interest due to its diverse and potent secondary metabolites, its role in soil ecology, and its potential applications in various biotechnological fields.

Streptomyces luteogriseus is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, including antibiotics and antifungal agents. This organism is particularly interesting due to its extensive secondary metabolite production, which has made it a subject of extensive research in the field of natural product chemistry. Researchers have isolated several compounds from S. luteogriseus, including the potent antibiotic luteogrisein, which exhibits activity against a range of pathogenic bacteria. One of the unique aspects of S. luteogriseus is its genetic diversity, which allows it to adapt to various environmental conditions and produce different metabolites. This adaptability is a key area of interest for scientists looking to harness its capabilities for drug discovery and development. The organism thrives in soil environments, contributing to its role in the ecosystem as a decomposer and nutrient recycler. Furthermore, S. luteogriseus serves as a model organism for studying the biosynthesis of secondary metabolites, providing insights into the genetic and biochemical pathways involved. Its genome has been sequenced, revealing clusters of genes responsible for the production of its bioactive compounds, making it a valuable resource for biotechnological applications. Overall, Streptomyces luteogriseus stands out not only for its ecological importance but also for its potential contributions to medicine and biotechnology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces luteogriseus

NCBI ID

68233

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/036/243/495/GCF_036243495.1_ASM3624349v1

File for sequence-based predictions:
GCF_036243495.1_ASM3624349v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces luteogriseus is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. This microorganism has been studied for its potential in antimicrobial therapy, particularly due to its ability to produce various secondary metabolites that exhibit antibacterial and antifungal properties. One of the notable compounds produced by S. luteogriseus is luteogrisein, which has shown effectiveness against certain pathogenic bacteria, making it a candidate for further research in the development of new antibiotics to combat antimicrobial resistance. In terms of pathogenicity, S. luteogriseus is generally considered non-pathogenic to humans; however, its close relatives within the Streptomyces genus can occasionally be associated with opportunistic infections, particularly in immunocompromised individuals. The organism's ability to produce a variety of enzymes and metabolites may also play a role in its interaction with the human microbiome, potentially influencing immune responses. Furthermore, the use of S. luteogriseus in probiotic formulations is an area of interest, as certain strains may contribute positively to gut health and overall human health. The organism's role in soil ecosystems and its interactions with plants also highlight its importance in agricultural applications, where it can promote plant growth and health through the production of beneficial compounds. Overall, while Streptomyces luteogriseus is primarily recognized for its contributions to antibiotic production and potential therapeutic applications, its interactions with human health and disease remain an important area for ongoing research.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces luteogriseus is a filamentous bacterium commonly found in soil ecosystems and is particularly abundant in terrestrial biomes such as tropical rainforests and temperate forests. This microorganism thrives in nutrient-rich environments where it plays a crucial role in the decomposition of organic matter, contributing to nutrient cycling and soil health. Its ability to produce a wide array of bioactive compounds, including antibiotics, makes it a significant player in the microbial community of these habitats. In its natural habitat, Streptomyces luteogriseus engages in competitive interactions with other soil microorganisms, often inhibiting the growth of pathogenic bacteria through the secretion of antimicrobial substances. This not only helps maintain the balance of microbial populations but also supports plant health by reducing soil-borne diseases. Additionally, Streptomyces luteogriseus exhibits symbiotic relationships with various plants, aiding in nutrient uptake and enhancing plant growth through the production of growth-promoting substances. Its adaptability to different soil types and conditions allows it to thrive in diverse environments, making it an essential component of the soil microbiome. Overall, Streptomyces luteogriseus is integral to the functioning of ecosystem processes, contributing to soil fertility, plant health, and the overall stability of the terrestrial biomes it inhabits.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces luteogriseus is renowned for its significant contributions to various industrial applications. One of the most notable areas is in pharmaceutical development, where S. luteogriseus is known to produce a range of bioactive compounds, including antibiotics. This organism is particularly famous for its ability to synthesize antibiotics through the fermentation process, making it a valuable resource in the fight against bacterial infections. In addition to its pharmaceutical uses, S. luteogriseus plays a role in biotechnology through its enzymatic activities. It produces enzymes that can be harnessed for various biotechnological applications, including the breakdown of complex organic materials. This capability is particularly useful in waste management, where the organism can aid in the biodegradation of pollutants and organic waste, contributing to more sustainable waste treatment solutions. Furthermore, S. luteogriseus has potential in the field of biofuel production. Its metabolic pathways can be exploited to convert biomass into biofuels, particularly through the fermentation of plant materials, which can lead to the production of bioethanol and other renewable energy sources. Overall, Streptomyces luteogriseus exemplifies the versatility of actinobacteria in industrial applications, particularly in pharmaceuticals, biotechnology, waste management, and biofuels, showcasing its importance in modern bioprocessing and environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	google/gemini-pro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	openchat/openchat-7b	openchat/openchat-7b	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	N/A	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerotolerant ✗	aerobic ✓	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	false	false
Animal pathogenicity	N/A	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	true	false	true	true	true	true	false	false	true	true	true	true	true	true	false	false	true	true	true	true	false	false	true	true	false	false	false	false
Host association	FALSE	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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