Haemophilus paracuniculus

General Information

Haemophilus paracuniculus is a fascinating microorganism that belongs to the genus Haemophilus. This genus is known for its small, pleomorphic, and fastidious nature, often requiring specific growth factors such as X (hemin) and V (NAD) factors for optimal growth. What makes H. paracuniculus particularly interesting is its close relationship to other Haemophilus species, which are known to inhabit the mucosal surfaces of humans and animals. One of the key characteristics of H. paracuniculus is its potential role in the respiratory tract of rabbits, from which it was originally isolated. This association suggests that it may play a role in the respiratory health of these animals, either as a commensal organism or as a pathogen under certain conditions. From a research perspective, H. paracuniculus is valuable due to its genetic and phenotypic similarities to other Haemophilus species, such as Haemophilus influenzae, which is a well-known human pathogen. Studying H. paracuniculus can provide insights into the evolution, pathogenic mechanisms, and host interactions of the Haemophilus genus. Moreover, the study of H. paracuniculus can contribute to our understanding of zoonotic diseases, as it highlights the potential for cross-species transmission of Haemophilus species. This is particularly important in the context of emerging infectious diseases and the need for comprehensive surveillance of animal reservoirs. In summary, Haemophilus paracuniculus is a microorganism of significant interest due to its unique ecological niche, its relationship to other medically important Haemophilus species, and its potential implications for both veterinary and human health research.

Haemophilus paracuniculus is a fascinating bacterium that was first identified in the context of rabbit microbiota. This organism is particularly interesting due to its unique ecological niche and its role in the health of its host. It is part of the normal flora of rabbits, contributing to the maintenance of gut health and potentially influencing the immune system of the host. One of the most notable aspects of H. paracuniculus is its metabolic capabilities. It has been shown to utilize a variety of nutrients, which allows it to thrive in the complex environment of the rabbit gut. This adaptability makes it a valuable model for studying microbial interactions within a host and understanding how gut microbiota can affect overall health. From a research perspective, H. paracuniculus offers insights into host-microbe interactions. Its presence in the gastrointestinal tract of rabbits provides a unique opportunity to explore how specific bacteria can influence digestion, nutrient absorption, and even the immune response. Furthermore, studying this organism can shed light on the evolutionary relationships among the Haemophilus genus, particularly in relation to other species that inhabit different hosts. In summary, Haemophilus paracuniculus stands out due to its ecological significance, metabolic versatility, and the potential it holds for advancing our understanding of microbial ecology and host interactions. Its study could lead to broader implications in fields such as veterinary medicine, microbiome research, and even comparative immunology.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Gammaproteobacteria

Order: Pasteurellales

Family: Pasteurellaceae

Genus: Haemophilus

Species: Haemophilus paracuniculus

NCBI ID

734

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/002/015/115/GCF_002015115.1_ASM201511v1

File for sequence-based predictions:
GCF_002015115.1_ASM201511v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Haemophilus paracuniculus is a lesser-known member of the genus Haemophilus, which includes several clinically significant species. While specific clinical implications of H. paracuniculus are not extensively documented, its close relatives, such as Haemophilus influenzae, provide insight into potential relevance. H. paracuniculus has been isolated from human clinical specimens, suggesting a possible role in infections or as a commensal organism in the human microbiome. Clinical associations may include respiratory tract infections, particularly in immunocompromised individuals. The organism's ability to colonize mucosal surfaces could indicate a potential for pathogenicity, especially in patients with underlying health conditions. Antimicrobial resistance is a significant concern within the Haemophilus genus, with some strains exhibiting resistance to commonly used antibiotics. This resistance can complicate treatment options for infections caused by related species, and it raises the possibility that H. paracuniculus may share similar resistance mechanisms, although specific data on this organism is limited. In terms of immune evasion, members of the Haemophilus genus often possess polysaccharide capsules that help them evade host immune responses. If H. paracuniculus shares this characteristic, it could contribute to its survival and potential pathogenicity in human hosts. Overall, while H. paracuniculus is not as well-studied as other members of its genus, its presence in clinical samples warrants further investigation to fully understand its role in human health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Haemophilus paracuniculus is a bacterium primarily associated with the mammalian gastrointestinal tract, particularly in rabbits. This organism thrives in the microbial communities of the gut, where it plays a significant role in the digestion of complex carbohydrates and the synthesis of essential vitamins. Its presence is crucial for maintaining a balanced gut microbiome, contributing to the overall health of its host by aiding in nutrient absorption and preventing the colonization of pathogenic bacteria. In the gut environment, H. paracuniculus exhibits symbiotic relationships with other gut flora, facilitating a diverse microbial ecosystem. This bacterium can adapt to varying conditions within the gut, such as changes in pH and nutrient availability, showcasing its ecological flexibility. Additionally, H. paracuniculus may also be found in environments where its host resides, such as burrows or nests, where it can influence the microbial composition of the surrounding soil and contribute to nutrient cycling. Its interactions with the host and other microorganisms underscore its importance in the ecosystem dynamics of the habitats it occupies.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Haemophilus paracuniculus has shown potential in various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This organism is known for its role in fermentation, where it can contribute to the production of specific metabolites that may have therapeutic properties. For instance, its ability to metabolize certain substrates can lead to the generation of bioactive compounds that are valuable in drug formulation. In the realm of waste management, Haemophilus paracuniculus has been studied for its capacity to degrade organic waste materials. This biodegradation process is crucial for reducing environmental pollution and can be harnessed in waste treatment facilities to enhance the breakdown of complex organic compounds, thereby improving waste management efficiency. Moreover, the enzymatic activity of Haemophilus paracuniculus can be leveraged in biofuel production. The organism may participate in enzyme production that facilitates the conversion of biomass into biofuels, making it a candidate for sustainable energy solutions. Its metabolic pathways can be optimized to enhance the yield of biofuels from agricultural residues or other organic materials. Overall, Haemophilus paracuniculus presents a promising avenue for research and development in these industries, with its applications in fermentation, waste treatment, and enzyme production highlighting its versatility and potential impact on industrial processes.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	openai/gpt-3.5-turbo-0125	anthropic/claude-3.5-sonnet	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-flash-1.5	perplexity/llama-3-sonar-small-32k-chat	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	google/gemini-pro	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	N/A	false	false	false	true	true	false	false	true	false	true	false	false	false	false	true	true	false	false	true	true	true	true	true	true	false	false
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	facultatively anaerobic ✗	aerobic ✓	aerobic ✓	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	false	false	true	true	false	false	true	true	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	false	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Hemolysis	N/A	N/A	N/A	N/A	alpha	beta	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	coccus ✗	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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