[Clostridium] innocuum

General Information

Clostridium innocuum is a fascinating microorganism that belongs to the genus Clostridium. One of the most intriguing aspects of C. innocuum is its ability to thrive in diverse environments, which makes it a subject of interest in various fields of microbiological research. This organism is particularly notable for its association with human health, as it has been isolated from the gastrointestinal tract and is sometimes implicated in infections, especially in immunocompromised individuals. Another unique characteristic of C. innocuum is its resistance to certain antibiotics, which poses challenges in clinical settings. This resistance highlights the importance of understanding its genetic and biochemical pathways to develop effective treatment strategies. Additionally, C. innocuum has been studied for its metabolic capabilities, including the production of specific enzymes that can break down complex carbohydrates, making it a potential candidate for industrial applications in biotechnology. From a research perspective, C. innocuum serves as a model organism for studying the dynamics of gut microbiota and its interactions with the host. Its presence in the gut microbiome and its potential role in maintaining or disrupting gut health provide valuable insights into the complex relationships between microorganisms and human health. In summary, Clostridium innocuum is a microorganism of significant interest due to its clinical relevance, antibiotic resistance, metabolic versatility, and role in the gut microbiome. These characteristics make it a valuable subject for ongoing research in microbiology, medicine, and biotechnology.

Clostridium innocuum is a fascinating anaerobic bacterium belonging to the genus Clostridium, which is known for its diverse metabolic capabilities and ecological significance. This species is particularly interesting due to its ability to produce a variety of enzymes, including proteases and lipases, which can be valuable in industrial applications such as bioremediation and the production of biofuels. The metabolic versatility of C. innocuum allows it to thrive in various environments, including soil and the gastrointestinal tracts of animals, making it an important player in nutrient cycling. One of the unique aspects of C. innocuum is its potential role in the degradation of complex organic materials, which can contribute to the breakdown of waste products in anaerobic digesters. This characteristic positions it as a candidate for research in waste management and environmental sustainability. Furthermore, the study of C. innocuum can provide insights into the mechanisms of anaerobic metabolism, which are crucial for understanding broader ecological interactions and the evolution of microbial communities. In addition to its ecological roles, C. innocuum has been investigated for its potential in biotechnology, particularly in the production of short-chain fatty acids, which are important for various industrial processes. The ability of this organism to ferment a wide range of substrates makes it a valuable model for metabolic engineering studies aimed at optimizing fermentation processes. Overall, Clostridium innocuum stands out as a microorganism of interest not only for its ecological contributions but also for its potential applications in biotechnology and environmental science.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacillota

Class: Erysipelotrichia

Order: Erysipelotrichales

Family: Erysipelotrichaceae

Genus: NA

Species: [Clostridium] innocuum

NCBI ID

1522

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/022/845/735/GCA_022845735.1_ASM2284573v1

File for sequence-based predictions:
GCA_022845735.1_ASM2284573v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Clostridium innocuum is a member of the Clostridia class and is known for its role in human health and disease. While it is primarily considered a commensal organism found in the human gut, it has been associated with various clinical implications, particularly in immunocompromised patients. Infections caused by C. innocuum are relatively rare but can occur, leading to soft tissue infections and abscesses. Its pathogenicity is often linked to its ability to produce toxins and its potential to form biofilms, which can complicate treatment. One of the significant concerns regarding C. innocuum is its potential for antimicrobial resistance. Strains have been documented to exhibit resistance to multiple antibiotics, which poses challenges in managing infections effectively. This resistance is often attributed to the organism's natural habitat in the gut, where it can acquire resistance genes from other bacteria. In terms of immune evasion, C. innocuum can manipulate host immune responses, allowing it to persist in the human body without being effectively cleared by the immune system. This characteristic is particularly concerning in patients with weakened immune systems, where the risk of severe infections increases. While C. innocuum is not commonly associated with large outbreaks, its presence in clinical settings underscores the importance of monitoring for potential infections, especially in vulnerable populations. Overall, understanding the clinical implications of Clostridium innocuum is crucial for effective diagnosis and treatment strategies.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Clostridium innocuum is a bacterium commonly found in various anaerobic environments, particularly in the gastrointestinal tracts of animals and humans. This organism thrives in microaerophilic conditions, where oxygen levels are low, making it well-adapted to the intestinal biome of mammals. Its presence is significant in the breakdown of complex carbohydrates, contributing to the fermentation processes that occur in the gut. In the soil biome, C. innocuum can also be found, where it plays a role in the decomposition of organic matter. This bacterium is involved in the cycling of nutrients, particularly in the breakdown of proteins and amino acids, which enriches the soil and supports plant growth. Notably, Clostridium innocuum can engage in symbiotic relationships with other gut microbiota, aiding in digestion and maintaining a balanced microbial community. Its ability to produce short-chain fatty acids during fermentation is crucial for the health of the host, providing energy and influencing immune responses. Overall, C. innocuum exemplifies the importance of anaerobic bacteria in both the gastrointestinal tract and soil ecosystems, highlighting its role in nutrient cycling and symbiotic interactions within these biomes.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Clostridium innocuum has several notable industrial applications primarily in the fields of biotechnology, waste management, and biofuel production. This anaerobic bacterium is known for its ability to perform fermentation, which is a critical process in the production of various organic compounds. For instance, Clostridium innocuum can be utilized in the fermentation of carbohydrates to produce short-chain fatty acids, which are valuable in the food and feed industries. In the realm of waste management, Clostridium innocuum plays a significant role in the biodegradation of organic waste. Its ability to break down complex organic materials makes it a candidate for anaerobic digestion, a process that converts waste into biogas, a renewable energy source. This process not only helps in waste reduction but also contributes to sustainable energy production. Furthermore, the enzymatic activity of Clostridium innocuum is of interest in pharmaceutical development. The bacterium can produce various enzymes that may be harnessed for the synthesis of bioactive compounds, potentially leading to the development of new drugs or therapeutic agents. Overall, Clostridium innocuum demonstrates significant potential in various industries through its capabilities in fermentation, biodegradation, and enzyme production, making it a valuable organism for future biotechnological advancements.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	openai/gpt-3.5-turbo-0125	openai/gpt-4o	anthropic/claude-3.5-sonnet	google/gemini-pro-1.5	openai/gpt-4	meta-llama/llama-3-70b-instruct:nitro	google/gemma-7b-it	microsoft/wizardlm-2-8x22b	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct
Motility	N/A	false	false	false	false	true	false	false	true	true	false	false	false	false	false	false	false	true	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain negative ✗	gram stain negative ✗	gram stain variable ✗
Aerophilicity	anaerobic	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗
Biofilm formation	N/A	true	true	false	true	false	false	true	true	true	true	true	true	true	true	false	true	true	true
Animal pathogenicity	TRUE	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗
Biosafety level	biosafety level 2	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓
Health association	FALSE	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓
Host association	TRUE	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	spirillum	bacillus	bacillus

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