Burkholderia ambifaria

General Information

Burkholderia ambifaria is a fascinating microorganism belonging to the Burkholderia cepacia complex, a group of genetically similar but phenotypically diverse bacteria. One of the most intriguing aspects of B. ambifaria is its dual role in both agriculture and human health. In agriculture, B. ambifaria is known for its plant growth-promoting properties. It can produce a variety of secondary metabolites, including antibiotics and antifungal compounds, which help protect plants from pathogens. This makes it a valuable candidate for use as a biocontrol agent in sustainable agriculture. On the other hand, B. ambifaria is also recognized for its potential pathogenicity in humans, particularly in individuals with cystic fibrosis or compromised immune systems. This dual nature makes it a subject of intense study, as researchers aim to harness its beneficial properties while mitigating its risks. Another unique feature of B. ambifaria is its metabolic versatility. It can degrade a wide range of organic compounds, including pollutants, making it a candidate for bioremediation efforts. This ability to break down environmental contaminants highlights its ecological importance and potential utility in cleaning up polluted environments. Genomic studies of B. ambifaria have revealed a complex and adaptable genome, which contributes to its ability to thrive in diverse environments. The presence of multiple gene clusters for secondary metabolite production underscores its potential for producing novel bioactive compounds, which could be of pharmaceutical interest. In summary, Burkholderia ambifaria is a microorganism of significant interest due to its plant growth-promoting abilities, potential pathogenicity, metabolic versatility, and genomic complexity. Its study offers valuable insights into microbial ecology, biotechnology, and infectious disease management.

Burkholderia ambifaria is a fascinating bacterium that belongs to the genus Burkholderia, which is known for its diverse metabolic capabilities and ecological versatility. This species is particularly interesting due to its ability to thrive in various environments, including soil and water, and its role in the nitrogen cycle. One of the most notable characteristics of B. ambifaria is its potential as a biocontrol agent; it has been studied for its ability to suppress plant pathogens, making it valuable in agricultural research aimed at sustainable practices. Additionally, B. ambifaria is recognized for its intriguing interactions with plants. It can form beneficial relationships with certain plant species, promoting growth and enhancing resistance to diseases. This symbiotic relationship highlights its potential in bioremediation and phytoremediation efforts, where it can help in the detoxification of contaminated environments. From a medical perspective, Burkholderia ambifaria is also noteworthy due to its opportunistic pathogenicity in immunocompromised individuals. Understanding its pathogenic mechanisms can provide insights into the treatment of infections caused by related species, particularly in patients with cystic fibrosis or other underlying health conditions. This dual role as both a beneficial organism and a potential pathogen makes B. ambifaria a subject of significant interest in both environmental and clinical microbiology. In summary, the unique ecological roles, potential agricultural benefits, and medical implications of Burkholderia ambifaria underscore its importance in research, making it a valuable organism for further study in various scientific fields.

Taxonomy

Superkingdom: Bacteria

Phylum: Pseudomonadota

Class: Betaproteobacteria

Order: Burkholderiales

Family: Burkholderiaceae

Genus: Burkholderia

Species: Burkholderia ambifaria

NCBI ID

152480

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/016/127/755/GCA_016127755.1_ASM1612775v1

File for sequence-based predictions:
GCA_016127755.1_ASM1612775v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Burkholderia ambifaria is a member of the Burkholderia genus, which is known for its clinical significance, particularly in immunocompromised patients. It is associated with chronic lung infections in individuals with cystic fibrosis and can lead to severe respiratory complications. The pathogenicity of B. ambifaria is attributed to its ability to form biofilms, which enhances its resistance to both the host immune response and antimicrobial agents. Antimicrobial resistance is a notable concern, as strains of B. ambifaria have demonstrated resistance to multiple classes of antibiotics, complicating treatment options. Furthermore, this organism can evade the immune response through various mechanisms, including the production of virulence factors that inhibit phagocytosis and modulate inflammatory responses. In terms of medical applications, while B. ambifaria is not typically used as a probiotic, understanding its interactions with the human microbiome may provide insights into potential therapeutic strategies for managing infections. Overall, the clinical implications of Burkholderia ambifaria underscore the importance of monitoring and addressing its role in respiratory diseases, particularly in vulnerable populations.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Burkholderia ambifaria is a versatile bacterium commonly found in a variety of habitats and environments, particularly in soil and water ecosystems. This microorganism thrives in nutrient-rich environments, often associated with decaying organic matter, where it plays a crucial role in the decomposition process. Its ability to degrade a wide range of organic compounds makes it an important player in nutrient cycling within these biomes. Soil ecosystems are one of the primary habitats for Burkholderia ambifaria. Here, it interacts with plant roots, contributing to plant health through mechanisms such as nitrogen fixation and the production of growth-promoting substances. This symbiotic relationship enhances nutrient availability for plants, thereby supporting overall ecosystem productivity. In addition to soil, Burkholderia ambifaria is also found in aquatic environments, including freshwater and marine systems. In these habitats, it can be involved in the breakdown of pollutants, showcasing its potential for bioremediation. Its presence in these environments indicates a role in maintaining water quality and supporting microbial diversity. Furthermore, Burkholderia ambifaria exhibits notable adaptability to various environmental stresses, such as changes in temperature and pH, which allows it to thrive in diverse ecological niches. This adaptability not only aids in its survival but also enhances its interactions with other microorganisms, contributing to the overall resilience of the ecosystems it inhabits. Overall, Burkholderia ambifaria is a key organism in both terrestrial and aquatic biomes, playing significant roles in nutrient cycling, plant health, and environmental remediation.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Burkholderia ambifaria has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where Burkholderia ambifaria is utilized for its ability to produce a range of enzymes that can be harnessed in biocatalysis and bioprocessing. These enzymes are particularly valuable in the food industry for processes such as fermentation, where they can enhance flavor profiles and improve the efficiency of production. In the realm of waste management, Burkholderia ambifaria has demonstrated capabilities in biodegradation, particularly in the breakdown of complex organic pollutants. This makes it a candidate for use in bioremediation efforts, where it can help clean up contaminated environments, such as oil spills or heavy metal-laden sites. Furthermore, the organism has been explored for its potential in biofuel production. Its metabolic pathways can be engineered to optimize the conversion of biomass into biofuels, making it a valuable asset in the pursuit of sustainable energy solutions. In pharmaceutical development, Burkholderia ambifaria has been studied for its production of secondary metabolites that may have therapeutic properties. This includes the synthesis of compounds that could be used in the development of new antibiotics or other medicinal products. Overall, Burkholderia ambifaria represents a versatile microorganism with applications spanning across biotechnology, waste management, biofuel production, and pharmaceutical development, showcasing its importance in modern industrial processes.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-pro-1.5	anthropic/claude-3-haiku:beta	anthropic/claude-3.5-sonnet	meta-llama/llama-3-70b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	google/gemini-pro	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	google/gemma-7b-it	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openchat/openchat-7b	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	aerobic ✓	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	true	true	true	true	true	true	false	false	true	true	true	true	false	false	true	true	true	true	true	true	true	true	false	false	false	false	true	true	false	false
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	gamma	N/A	beta ✗	N/A	N/A	N/A	N/A	N/A	N/A	gamma ✓	gamma ✓	alpha ✗	alpha ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓

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