Corynebacterium kroppenstedtii

General Information

Corynebacterium kroppenstedtii is a fascinating microorganism that has garnered attention due to its unique characteristics and potential implications in human health. This bacterium is part of the genus Corynebacterium, which includes several species known for their diverse roles in both environmental and clinical settings. One of the most intriguing aspects of C. kroppenstedtii is its association with certain types of breast infections, particularly granulomatous mastitis. This condition is a chronic inflammatory disease of the breast, and the presence of C. kroppenstedtii has been frequently noted in affected tissues. The exact mechanism by which this bacterium contributes to the disease is still under investigation, making it a subject of significant research interest. Another noteworthy feature of C. kroppenstedtii is its lipid-rich cell wall. Unlike many other Corynebacterium species, C. kroppenstedtii lacks mycolic acids, which are long-chain fatty acids typically found in the cell walls of related bacteria. Instead, it has a high content of other lipids, which may play a role in its pathogenicity and interaction with host tissues. From a biotechnological perspective, C. kroppenstedtii is valuable for studying the metabolic pathways involved in lipid synthesis and degradation. Understanding these pathways can provide insights into the development of new antibiotics and treatments for infections caused by lipid-rich bacteria. In summary, Corynebacterium kroppenstedtii stands out due to its association with granulomatous mastitis, its unique lipid-rich cell wall, and its potential as a model organism for studying lipid metabolism. These characteristics make it a valuable subject for ongoing research in microbiology and infectious diseases.

Corynebacterium kroppenstedtii is a fascinating species within the genus Corynebacterium, notable for its unique biochemical properties and ecological significance. This organism is primarily recognized for its role in the human microbiome, particularly in the context of skin and mucosal surfaces. Its ability to thrive in diverse environments makes it an interesting subject for research into microbial ecology and host interactions. One of the most intriguing aspects of C. kroppenstedtii is its potential involvement in human health. Studies have suggested that it may play a role in maintaining skin homeostasis and could be linked to various dermatological conditions. This connection to human health underscores its value in clinical microbiology and the study of skin microbiota. Additionally, C. kroppenstedtii has been explored for its metabolic capabilities, particularly in the degradation of complex organic compounds. This characteristic positions it as a potential candidate for biotechnological applications, such as bioremediation or the production of valuable metabolites. The organism's metabolic versatility highlights its potential utility in environmental microbiology and industrial processes. Overall, Corynebacterium kroppenstedtii stands out due to its dual significance in both human health and environmental applications, making it a valuable organism for ongoing research in microbiology and biotechnology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Mycobacteriales

Family: Corynebacteriaceae

Genus: Corynebacterium

Species: Corynebacterium kroppenstedtii

NCBI ID

161879

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/016/889/365/GCA_016889365.1_ASM1688936v1

File for sequence-based predictions:
GCA_016889365.1_ASM1688936v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Corynebacterium kroppenstedtii is a member of the genus Corynebacterium, which includes several species known for their clinical significance. This particular species has been associated with various infections, particularly in immunocompromised patients. It is known to be a part of the normal flora of the human skin and mucous membranes, but it can become pathogenic under certain conditions. Clinical implications of Corynebacterium kroppenstedtii include its potential role in causing skin infections, respiratory infections, and soft tissue infections. One of the notable aspects of Corynebacterium kroppenstedtii is its antimicrobial resistance. It has shown resistance to multiple antibiotics, which complicates treatment options for infections caused by this organism. The mechanisms of resistance may involve the production of beta-lactamases and other enzymatic modifications that render common antibiotics ineffective. In terms of immune evasion, Corynebacterium kroppenstedtii can produce various virulence factors that help it survive in the host environment, including the ability to form biofilms, which protect it from both the host immune response and antibiotic treatment. While there is limited information on specific outbreaks directly linked to Corynebacterium kroppenstedtii, its presence in clinical specimens has been noted, raising concerns about its role in nosocomial infections. Further research is needed to fully understand its pathogenic potential and the implications for public health. Overall, Corynebacterium kroppenstedtii represents a significant concern in clinical microbiology, particularly regarding its role in opportunistic infections and antibiotic resistance.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Corynebacterium kroppenstedtii is a bacterium commonly associated with the human microbiome, particularly in the skin and mucosal surfaces of the respiratory tract. This organism thrives in environments that are rich in nutrients and moisture, making it well-suited for colonization in these areas. Its presence is often linked to the maintenance of a balanced microbial community, playing a crucial role in preventing the overgrowth of pathogenic bacteria through competitive exclusion and the production of antimicrobial substances. In the skin biome, Corynebacterium kroppenstedtii contributes to the overall health of the skin by participating in the microbial diversity that is essential for skin barrier function. It can be found in areas with higher moisture levels, such as the axillary region and interdigital spaces, where it interacts with other skin flora to maintain homeostasis. In the respiratory tract, this bacterium is part of the normal flora, where it may help in the modulation of immune responses and the prevention of respiratory infections. Its ability to adapt to varying oxygen levels allows it to thrive in both aerobic and anaerobic conditions, showcasing its environmental adaptability. Overall, Corynebacterium kroppenstedtii exemplifies the importance of microbial communities in maintaining health and preventing disease, highlighting its role in symbiotic relationships with its human host and other microorganisms.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Corynebacterium kroppenstedtii has shown significant potential in various industrial applications. One of the most notable areas is in biotechnology, where it is utilized for the production of amino acids, particularly L-lysine, which is essential in animal feed and human nutrition. This process involves fermentation, where the organism converts carbohydrates into amino acids, making it a valuable asset in the food and feed industries. In the realm of waste management, Corynebacterium kroppenstedtii has been studied for its ability to degrade certain pollutants, contributing to biodegradation processes. This capability can be harnessed in the treatment of wastewater, where the microorganism can help break down organic matter and reduce the environmental impact of waste. Furthermore, there is potential for Corynebacterium kroppenstedtii in pharmaceutical development. Its metabolic pathways can be explored for the production of various bioactive compounds, which may lead to the discovery of new drugs or therapeutic agents. The organism's enzymatic activity can be particularly useful in the synthesis of complex molecules. Overall, Corynebacterium kroppenstedtii represents a versatile microorganism with applications spanning biotechnology, waste management, and pharmaceutical development, showcasing its importance in sustainable industrial practices.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	openai/gpt-3.5-turbo-0125	anthropic/claude-3-haiku:beta	google/gemini-flash-1.5	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro-1.5	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	mistralai/mistral-7b-instruct	google/gemini-pro	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-70b-instruct:nitro	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	facultatively anaerobic ✗	N/A	N/A	facultatively anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	aerotolerant ✗	aerotolerant ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	FALSE	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Host association	TRUE	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Hemolysis	N/A	N/A	alpha	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

Back to Search