Rothia aeria

General Information

Rothia aeria is a fascinating microorganism that belongs to the genus Rothia. This bacterium is particularly interesting due to its unique habitat and potential applications in biotechnology and medicine. Originally isolated from the air, Rothia aeria has adapted to thrive in various environments, including the human oral cavity. This adaptability makes it a subject of interest for researchers studying microbial ecology and the dynamics of microbial communities in different environments. One of the most compelling aspects of Rothia aeria is its role in the human microbiome. It is part of the normal flora of the mouth and has been implicated in both health and disease. For instance, it has been found in dental plaque and is thought to play a role in oral health by competing with pathogenic bacteria. This competitive interaction can be crucial for maintaining a balanced microbial community, which is essential for preventing oral diseases such as caries and periodontitis. From a biotechnological perspective, Rothia aeria is noteworthy for its enzymatic capabilities. It produces various enzymes that can degrade complex carbohydrates, which has potential applications in industrial processes. These enzymes could be harnessed for the production of biofuels, bioplastics, and other valuable biochemicals, making Rothia aeria a promising candidate for sustainable biotechnological innovations. Moreover, Rothia aeria has been studied for its antimicrobial properties. Some strains produce substances that inhibit the growth of other bacteria, which could be developed into new antimicrobial agents. This is particularly important in the context of rising antibiotic resistance, as new antimicrobial compounds are urgently needed. In summary, Rothia aeria is a microorganism of significant interest due to its ecological role, biotechnological potential, and contribution to human health. Its ability to adapt to different environments, produce valuable enzymes, and exhibit antimicrobial properties makes it a valuable subject for ongoing research and potential applications in various fields.

Rothia aeria is a fascinating member of the genus Rothia, which is known for its unique ecological niche and potential implications in human health. This microorganism is primarily isolated from the respiratory tract, particularly in individuals with respiratory conditions, making it an interesting subject for research into its role in pulmonary health and disease. Its ability to thrive in the human microbiome suggests a complex interaction with host immune responses, which could provide insights into microbial ecology and host-pathogen interactions. One of the most notable characteristics of Rothia aeria is its metabolic versatility. It has been shown to utilize a variety of carbohydrates, which allows it to adapt to different environments within the human body. This adaptability raises questions about its potential contributions to both health and disease states, particularly in the context of dysbiosis, where the balance of microbial communities is disrupted. Furthermore, Rothia aeria has garnered attention for its potential role in bioactive compound production. Some strains within the Rothia genus are known to produce antimicrobial substances, which could be valuable in the development of new therapeutic agents. This aspect of Rothia aeria makes it a candidate for further investigation in the search for novel antibiotics, especially in an era of increasing antibiotic resistance. In summary, Rothia aeria stands out due to its ecological significance in the human microbiome, its metabolic flexibility, and its potential for biotechnological applications. Continued research into this organism could unveil important insights into microbial interactions and lead to innovative approaches in treating respiratory diseases and combating antibiotic resistance.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Micrococcales

Family: Micrococcaceae

Genus: Rothia

Species: Rothia aeria

NCBI ID

172042

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/900/637/985/GCA_900637985.1_54949_H01

File for sequence-based predictions:
GCA_900637985.1_54949_H01_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Rothia aeria is a member of the normal flora of the human oral cavity and respiratory tract. While it is generally considered a commensal organism, it has been associated with certain clinical implications, particularly in immunocompromised patients. Infections caused by Rothia aeria are rare but can occur, leading to conditions such as bacteremia and endocarditis. Its role in these infections highlights the potential for opportunistic pathogenicity, especially in individuals with underlying health issues or those undergoing invasive procedures. One of the notable aspects of Rothia aeria is its potential for antimicrobial resistance. Reports have indicated that this organism may exhibit resistance to commonly used antibiotics, which complicates treatment options in cases of infection. This resistance underscores the importance of careful antibiotic stewardship and the need for susceptibility testing in clinical settings. In terms of immune evasion, Rothia aeria may possess mechanisms that allow it to persist in the human body without triggering a robust immune response, which can contribute to its opportunistic nature. Understanding these mechanisms is crucial for developing strategies to manage infections associated with this organism. While Rothia aeria is not commonly targeted in therapeutic applications, its presence in the oral microbiome suggests potential roles in maintaining oral health. Further research may elucidate its contributions to oral ecology and its interactions with other microbial communities, which could have implications for the development of probiotics or other therapeutic interventions aimed at restoring or maintaining a healthy microbiome.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Rothia aeria is a bacterium commonly associated with the human oral cavity and upper respiratory tract. This microorganism thrives in environments that are rich in organic matter and moisture, making it well-suited for the microbial communities found in these regions. Its presence is often linked to the oral microbiome, where it plays a significant role in maintaining the balance of microbial populations. In the oral cavity, Rothia aeria contributes to the breakdown of food particles and the production of metabolites that can influence the health of the host. It is known to engage in symbiotic relationships with other bacteria, helping to prevent the overgrowth of pathogenic species. This interaction is crucial for maintaining oral health and preventing conditions such as dental caries and periodontal disease. Additionally, Rothia aeria can be found in the nasopharyngeal region, where it may play a role in the immune response and the overall health of the respiratory system. Its ability to adapt to varying oxygen levels and nutrient availability allows it to thrive in these diverse environments. Overall, Rothia aeria is an important member of the microbial community, contributing to the ecological balance within the human microbiome.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Rothia aeria has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is known for its ability to thrive in diverse environments, which makes it a candidate for biodegradation processes. For instance, Rothia aeria can contribute to the breakdown of complex organic compounds, thereby aiding in the treatment of waste materials and reducing environmental pollution. In the realm of biofuel production, Rothia aeria may play a role in the fermentation of biomass, converting organic materials into bioethanol or other biofuels. This process involves fermentation, where the microorganism metabolizes sugars and starches, producing alcohol as a byproduct. Such applications are crucial for developing sustainable energy sources and reducing reliance on fossil fuels. Moreover, Rothia aeria has been studied for its potential in pharmaceutical development. Its unique metabolic pathways may lead to the discovery of novel compounds with antimicrobial properties, which can be harnessed in drug formulation. The enzymatic activities of Rothia aeria could also be explored for the production of specific enzymes used in various industrial processes, enhancing efficiency and reducing costs. Overall, the versatility of Rothia aeria in biodegradation, fermentation, and enzyme production highlights its significance in advancing sustainable practices across multiple industries.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	mistralai/mistral-7b-instruct	perplexity/llama-3-sonar-small-32k-chat	meta-llama/llama-3-70b-instruct:nitro	openchat/openchat-7b	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro
Motility	N/A	false	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	true	true	true	true	true	true	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain variable ✗	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain positive ✓	N/A	gram stain negative ✗	N/A	gram stain negative ✗	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	N/A	aerotolerant ✗	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	false	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	N/A	false	true	true	true	false	true	true	false	true	false	false	true	true	false	false	true	true	true	true	false	false	false	false	false	false	false	false
Biosafety level	biosafety level 2	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗	biosafety level 1 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Host association	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	N/A	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	coccus	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	coccus ✓	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	coccus ✓	coccus ✓	coccus ✓	coccus ✓

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