Saccharopolyspora erythraea

General Information

Saccharopolyspora erythraea is a fascinating microorganism primarily known for its role in the production of the antibiotic erythromycin. This actinobacterium is of significant interest in the field of biotechnology and pharmaceuticals due to its ability to synthesize this clinically important macrolide antibiotic. Erythromycin is widely used to treat a variety of bacterial infections, making S. erythraea a valuable organism for medical research and drug development. One of the unique aspects of S. erythraea is its complex secondary metabolism, which allows it to produce a range of bioactive compounds. This metabolic versatility is not only crucial for antibiotic production but also offers potential for the discovery of new drugs and therapeutic agents. Researchers are particularly interested in the genetic and enzymatic pathways involved in erythromycin biosynthesis, as understanding these pathways can lead to improved yields and the development of novel antibiotics. Moreover, S. erythraea has a distinctive filamentous morphology, which is characteristic of many actinobacteria. This morphology is associated with its ability to form mycelium-like structures, contributing to its efficiency in producing secondary metabolites. The organism's genome has been sequenced, providing valuable insights into its genetic makeup and the regulatory mechanisms governing its metabolic processes. In summary, Saccharopolyspora erythraea is a microorganism of great interest due to its antibiotic production capabilities, metabolic diversity, and genetic potential. Its contributions to medicine and biotechnology underscore its importance as a subject of ongoing research and development.

Saccharopolyspora erythraea is a notable actinobacterium primarily recognized for its role in the production of the antibiotic erythromycin. This organism is particularly interesting due to its ability to synthesize complex polyketides, which are crucial for the development of various pharmaceutical compounds. Erythromycin, derived from S. erythraea, is widely used to treat bacterial infections, making this microorganism invaluable in the field of medicine. One of the unique aspects of S. erythraea is its genetic and metabolic pathways that allow for the biosynthesis of erythromycin. Researchers have extensively studied these pathways to enhance antibiotic production and to explore the potential for developing new antibiotics, especially in the face of rising antibiotic resistance. The genome of S. erythraea has been sequenced, providing insights into its metabolic capabilities and the regulation of antibiotic biosynthesis, which is a significant area of interest in microbial genetics and biotechnology. Additionally, S. erythraea serves as a model organism for studying the ecology of soil-dwelling actinobacteria, contributing to our understanding of microbial diversity and the role of these organisms in natural antibiotic production. Its ability to thrive in various environments also makes it a subject of interest in studies related to environmental microbiology and bioremediation. In summary, Saccharopolyspora erythraea stands out not only for its antibiotic production but also for its contributions to research in microbial genetics, ecology, and biotechnology, making it a key player in the ongoing search for new therapeutic agents.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Pseudonocardiales

Family: Pseudonocardiaceae

Genus: Saccharopolyspora

Species: Saccharopolyspora erythraea

NCBI ID

1836

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/016/859/185/GCA_016859185.1_ASM1685918v1

File for sequence-based predictions:
GCA_016859185.1_ASM1685918v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Saccharopolyspora erythraea is primarily known for its role in the production of the antibiotic erythromycin, which is crucial in treating various bacterial infections. This actinobacterium is significant in the field of antimicrobial therapy, particularly for patients allergic to penicillin. Its ability to produce erythromycin makes it a valuable resource in combating Gram-positive bacterial infections and some Gram-negative infections as well. In terms of pathogenicity, Saccharopolyspora erythraea itself is not typically associated with human disease; however, its antibiotic production has implications for antimicrobial resistance. The widespread use of erythromycin has led to the emergence of resistant strains of bacteria, which poses a challenge in clinical settings. Understanding the mechanisms of resistance is crucial for developing new therapeutic strategies. Moreover, the organism has potential applications in probiotics and biotechnology, as its metabolic pathways can be harnessed for the production of other bioactive compounds. Research into its genetic makeup may lead to advancements in vaccine development or novel therapeutics. Overall, while Saccharopolyspora erythraea is not a direct pathogen, its contributions to medicine through antibiotic production and the implications of its use in treating infections underscore its importance in human health and disease management.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Saccharopolyspora erythraea is a filamentous bacterium primarily found in soil and decaying organic matter, particularly in tropical and subtropical regions. This microorganism thrives in nutrient-rich environments where it plays a crucial role in the decomposition of organic materials, contributing to nutrient cycling within the ecosystem. Its ability to produce a variety of secondary metabolites, including the antibiotic erythromycin, highlights its significance in microbial interactions and antibiotic production within its habitat. In addition to its role in decomposition, Saccharopolyspora erythraea is often associated with symbiotic relationships with plants, where it can enhance soil fertility and promote plant growth through the breakdown of complex organic compounds. This interaction underscores its importance in maintaining soil health and supporting biodiversity in its native environments. Overall, Saccharopolyspora erythraea exemplifies the intricate connections within terrestrial biomes, showcasing how microorganisms contribute to ecological balance and sustainability.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Saccharopolyspora erythraea is renowned for its significant contributions to pharmaceutical development, particularly in the production of the antibiotic erythromycin. This organism is utilized in the fermentation process, where it synthesizes erythromycin through a series of enzymatic reactions. The ability of Saccharopolyspora erythraea to produce this compound has made it a cornerstone in the pharmaceutical industry, providing an essential treatment for various bacterial infections. In addition to its role in pharmaceuticals, Saccharopolyspora erythraea has potential applications in biotechnology. Its metabolic pathways can be harnessed for the production of other bioactive compounds, which may lead to the development of new drugs or therapeutic agents. The organism's ability to produce secondary metabolites through fermentation processes is of particular interest in the field of natural product chemistry. Furthermore, there is ongoing research into the use of Saccharopolyspora erythraea in waste management. Its enzymatic capabilities may allow it to degrade complex organic materials, contributing to biodegradation processes that can help in the treatment of waste and the recycling of nutrients in industrial settings. Overall, Saccharopolyspora erythraea exemplifies the intersection of biotechnology, pharmaceutical development, and environmental management, showcasing its versatility and importance in various industrial applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	google/gemini-flash-1.5	google/gemini-flash-1.5	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	N/A	false	false	false	false	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerotolerant ✗	aerotolerant ✗	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	false	true	false	true	true	true	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	true	true	false	false	false	false
Host association	FALSE	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	N/A	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Hemolysis	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	gamma	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	N/A	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus	bacillus

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