Prevotella micans

General Information

Prevotella micans is a fascinating microorganism belonging to the genus Prevotella, which is known for its significant role in the human oral and gut microbiomes. One of the key characteristics of Prevotella micans is its ability to degrade complex carbohydrates, which makes it an important player in the digestion process. This species is particularly interesting due to its involvement in the breakdown of dietary fibers, contributing to the production of short-chain fatty acids (SCFAs) like acetate, propionate, and butyrate. These SCFAs are crucial for maintaining gut health and have been linked to various beneficial effects, including anti-inflammatory properties and energy provision for colonocytes. Another noteworthy aspect of Prevotella micans is its potential role in human health and disease. While members of the Prevotella genus are generally considered commensal organisms, some species have been associated with conditions such as periodontitis, bacterial vaginosis, and even systemic diseases like rheumatoid arthritis. The presence and abundance of Prevotella micans in the microbiome can thus provide valuable insights into the balance between health and disease states. From a research perspective, Prevotella micans is valuable for studying the interactions between diet, microbiome composition, and host health. Its ability to thrive on plant-based diets rich in fibers makes it a subject of interest in nutritional studies and the development of dietary interventions aimed at promoting gut health. Additionally, understanding the metabolic pathways and genetic mechanisms employed by Prevotella micans can lead to the discovery of novel enzymes and bioactive compounds with potential applications in biotechnology and medicine. In summary, Prevotella micans stands out due to its role in carbohydrate metabolism, impact on human health, and potential for biotechnological applications. Its study not only enhances our understanding of the complex interactions within the microbiome but also opens up avenues for therapeutic and industrial innovations.

Prevotella micans is a member of the genus Prevotella, which is known for its role in the human microbiome, particularly in the oral cavity and gastrointestinal tract. This species is particularly interesting due to its association with various human health conditions, including periodontal disease and other inflammatory processes. Its ability to metabolize a wide range of carbohydrates makes it a significant player in the fermentation processes occurring in the gut, contributing to the overall balance of the microbiota. One of the unique aspects of Prevotella micans is its potential involvement in the modulation of immune responses. Research has indicated that certain strains of Prevotella can influence the host's immune system, which may have implications for understanding autoimmune diseases and allergies. Furthermore, the presence of Prevotella micans in the oral microbiome has been linked to dental health, making it a valuable organism for studies focused on oral hygiene and the prevention of dental diseases. In addition, Prevotella micans has been studied for its metabolic capabilities, particularly in the context of its interactions with other microbial species. This can provide insights into microbial community dynamics and the role of specific bacteria in health and disease. Overall, the study of Prevotella micans offers valuable perspectives on microbial ecology, human health, and the intricate relationships within the microbiome.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacteroidota

Class: Bacteroidia

Order: Bacteroidales

Family: Prevotellaceae

Genus: Prevotella

Species: Prevotella micans

NCBI ID

189723

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/937/921/785/GCA_937921785.1_ERR589641_bin.81_CONCOCT_v1.1_MAG

File for sequence-based predictions:
GCA_937921785.1_ERR589641_bin.81_CONCOCT_v1.1_MAG_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Prevotella micans is part of the normal flora of the human oral cavity and gastrointestinal tract, but it has been associated with various clinical implications. Clinical relevance of Prevotella micans includes its potential role in periodontal disease, where it may contribute to the inflammatory processes that lead to tissue destruction. This organism is also implicated in soft tissue infections and has been isolated from abscesses in various body sites, indicating its pathogenic potential under certain conditions. In terms of immune evasion, Prevotella micans can produce enzymes that degrade host tissues and modulate the immune response, allowing it to persist in inflammatory environments. Its ability to form biofilms enhances its survival and resistance to antimicrobial agents, making infections difficult to treat. Antimicrobial resistance is a significant concern, as strains of Prevotella species, including micans, have shown resistance to commonly used antibiotics, complicating treatment options. While Prevotella micans is not typically used in medical applications like probiotics or vaccines, understanding its role in dysbiosis and disease states is crucial for developing targeted therapies. Further research is needed to fully elucidate its mechanisms of pathogenicity and potential therapeutic interventions.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Prevotella micans is a species of bacteria commonly found in the human oral cavity and gastrointestinal tract. This microorganism thrives in environments that are rich in organic matter and are often associated with the presence of other microbial communities. Its ecological niche is primarily within the anaerobic environments of the mouth and intestines, where it plays a significant role in the breakdown of complex carbohydrates and proteins, contributing to the overall health of the microbiome. In the oral biome, Prevotella micans is involved in the fermentation of dietary fibers and carbohydrates, producing short-chain fatty acids that are beneficial for the host. This bacterium can also interact with other species, forming complex biofilms that are essential for maintaining oral health. However, an imbalance in its population can lead to dental issues, highlighting its dual role as both a beneficial and potentially pathogenic organism. In the gastrointestinal tract, Prevotella micans contributes to the digestion of food and the synthesis of essential nutrients. It is known to engage in symbiotic relationships with other gut microbiota, enhancing nutrient absorption and supporting the immune system. The presence of Prevotella micans is often associated with a diet high in plant-based foods, indicating its adaptation to environments rich in dietary fibers. Overall, Prevotella micans exemplifies the intricate relationships within microbial communities, showcasing its importance in both the oral and gastrointestinal biomes and its role in maintaining the balance of the host's microbiome.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Prevotella micans has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is part of the gut microbiota and plays a significant role in the fermentation of carbohydrates, which can be harnessed for the production of bioactive compounds. In the realm of biofuel production, Prevotella micans can contribute to the breakdown of complex polysaccharides into simpler sugars, which are then fermented to produce bioethanol. This process is crucial for developing sustainable energy sources and reducing reliance on fossil fuels. Moreover, Prevotella micans has been studied for its ability to participate in biodegradation processes, particularly in the breakdown of organic waste materials. This capability is essential for waste management strategies, as it aids in the conversion of waste into less harmful substances, thereby promoting environmental sustainability. In the pharmaceutical industry, the metabolic byproducts of Prevotella micans may have implications for drug development, particularly in the synthesis of compounds that can influence human health. The organism's enzymatic activity can be explored for the production of specific metabolites that have therapeutic potential. Overall, Prevotella micans demonstrates a multifaceted role in various industries, particularly through its involvement in fermentation, biodegradation, and potential pharmaceutical development.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 8

LLM predicted phenotypes: 5

Phenotype	High-quality annotation	google/gemini-flash-1.5	anthropic/claude-3-haiku:beta	meta-llama/llama-3-70b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/palm-2-chat-bison-32k	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	google/gemini-pro	google/gemini-pro
Motility	N/A	false	true	false	true	true	true	true	false	true	true	true	false	false	false	false	false	false	false	false	false	false	true	true	false	false	true	true
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	anaerobic	N/A	N/A	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	facultatively anaerobic ✗	facultatively anaerobic ✗	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	aerotolerant ✗	aerotolerant ✗	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biofilm formation	FALSE	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Animal pathogenicity	FALSE	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	true ✗	true ✗
Biosafety level	N/A	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 2	biosafety level 1	biosafety level 1	biosafety level 2	biosafety level 2
Health association	N/A	true	true	true	true	true	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	N/A	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Hemolysis	N/A	gamma	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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