Streptomyces chartreusis

General Information

Streptomyces chartreusis is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most notable characteristics of S. chartreusis is its ability to produce a wide array of antibiotics, making it a valuable organism in the field of pharmaceutical research. Among the antibiotics it produces, chartreusin is particularly significant due to its potent antitumor properties. This compound has been the subject of extensive research for its potential applications in cancer therapy. Streptomyces chartreusis also exhibits a complex life cycle that includes the formation of mycelium and spores, which is typical of the Streptomyces genus. This life cycle is not only interesting from a biological standpoint but also important for the industrial production of its secondary metabolites. The organism's ability to thrive in various environments and its adaptability make it a robust candidate for biotechnological applications. Another intriguing aspect of S. chartreusis is its genetic makeup. The genome of S. chartreusis has been sequenced, revealing a wealth of biosynthetic gene clusters that are responsible for the production of its diverse secondary metabolites. This genetic information is invaluable for researchers aiming to discover new drugs and understand the biosynthetic pathways involved in antibiotic production. In summary, Streptomyces chartreusis is a microorganism of great interest due to its antibiotic production capabilities, complex life cycle, and rich genetic potential. Its contributions to medicine and biotechnology underscore its importance as a subject of ongoing scientific investigation.

Streptomyces chartreusis is a fascinating actinobacterium known for its remarkable ability to produce a variety of bioactive compounds, particularly the antibiotic chartreusin. This compound has garnered significant interest due to its effectiveness against a range of pathogenic bacteria and its potential applications in medical research and pharmaceuticals. The unique biosynthetic pathways utilized by S. chartreusis for the production of these secondary metabolites make it a valuable organism for biotechnological studies. One of the most intriguing aspects of S. chartreusis is its complex life cycle, which includes the formation of aerial hyphae and spores. This developmental process is not only essential for its reproduction but also plays a critical role in the organism's ability to adapt to various environmental conditions. The genetic and molecular mechanisms underlying these developmental stages are of great interest to researchers studying microbial differentiation and adaptation. Additionally, S. chartreusis has been shown to exhibit a diverse range of enzymatic activities, including the ability to degrade complex organic materials. This characteristic positions it as a potential candidate for bioremediation efforts, particularly in the breakdown of pollutants in soil and water. The exploration of its enzymatic capabilities could lead to innovative solutions for environmental challenges. Overall, Streptomyces chartreusis stands out not only for its antibiotic production but also for its ecological versatility and potential applications in biotechnology, making it a subject of ongoing research and interest in the fields of microbiology and pharmacology.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces chartreusis

NCBI ID

1969

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/008/704/715/GCF_008704715.1_ASM870471v1

File for sequence-based predictions:
GCF_008704715.1_ASM870471v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces chartreusis is a notable member of the genus Streptomyces, which is well-known for its role in the production of antibiotics. This species is particularly recognized for its ability to produce chartreusin, an antibiotic with significant activity against various bacterial pathogens. The clinical implications of Streptomyces chartreusis are multifaceted: 1. Antimicrobial Production: The primary clinical relevance of Streptomyces chartreusis lies in its production of chartreusin, which has been shown to exhibit potent activity against a range of Gram-positive and Gram-negative bacteria. This makes it a valuable organism in the field of antibiotic discovery and development. 2. Pathogenicity: While Streptomyces chartreusis is not typically associated with human disease, its close relatives within the Streptomyces genus can be opportunistic pathogens, particularly in immunocompromised individuals. Understanding the pathogenic potential of related species can provide insights into the risks associated with antibiotic production. 3. Antimicrobial Resistance: The emergence of antimicrobial resistance is a significant concern in modern medicine. While Streptomyces chartreusis itself is not known for resistance mechanisms, the study of its antibiotic production can inform strategies to combat resistant strains of bacteria, particularly those that are resistant to conventional antibiotics. 4. Medical Applications: Beyond its role in antibiotic production, there is potential for Streptomyces chartreusis to be explored in the development of novel therapeutics. Its metabolites may have applications in treating infections or could serve as a basis for new drug formulations. 5. Immune Evasion Strategies: Although Streptomyces chartreusis is not a human pathogen, understanding the immune evasion strategies of related Streptomyces species can provide insights into how these organisms survive in various environments, including those that may be hostile due to the presence of the human immune system. In summary, Streptomyces chartreusis holds significant promise in the field of antimicrobial research and development, with its antibiotic production capabilities being a key area of interest for addressing the challenges posed by antimicrobial resistance and the need for new therapeutic agents.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces chartreusis is a species of bacterium that thrives primarily in soil ecosystems and is particularly abundant in terrestrial biomes such as tropical rainforests and temperate forests. This microorganism is known for its ability to produce a variety of bioactive compounds, including antibiotics, which play a crucial role in its ecological niche. These compounds help inhibit the growth of competing microorganisms, allowing S. chartreusis to establish itself in nutrient-rich environments where organic matter is abundant. In addition to its role as a producer of antibiotics, Streptomyces chartreusis is involved in decomposition processes, breaking down complex organic materials and contributing to nutrient cycling within the soil. This activity not only enriches the soil but also supports plant growth, making it an essential player in the soil food web. Furthermore, S. chartreusis exhibits notable interactions with other organisms, including symbiotic relationships with plants. It can enhance plant health by promoting growth and providing resistance against pathogens through its antibiotic production. This symbiosis underscores the importance of Streptomyces species in maintaining the health of ecosystems and their resilience against environmental stressors. Overall, Streptomyces chartreusis is a vital component of soil biomes, contributing to both ecological balance and the health of terrestrial environments through its unique adaptations and interactions.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces chartreusis is renowned for its significant contributions to various industrial applications, particularly in the fields of biotechnology and pharmaceutical development. This actinobacterium is primarily recognized for its ability to produce a range of bioactive compounds, including antibiotics such as chartreusin, which has been shown to exhibit potent antibacterial properties. This makes Streptomyces chartreusis a valuable organism in the fermentation processes used for the production of pharmaceuticals. In addition to its role in antibiotic production, Streptomyces chartreusis is also involved in biodegradation processes, where it can break down complex organic materials, making it useful in waste management applications. The organism's enzymatic activity allows it to degrade various pollutants, contributing to the bioremediation of contaminated environments. Furthermore, the potential of Streptomyces chartreusis in biofuel production is being explored, particularly in the context of converting biomass into fermentable sugars through enzymatic activity. This could lead to more sustainable methods of producing biofuels, aligning with the growing demand for renewable energy sources. Overall, Streptomyces chartreusis exemplifies the versatility of microorganisms in industrial applications, showcasing its importance in fermentation, biodegradation, and enzyme production, thereby contributing to advancements in biotechnology and environmental sustainability.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/gemini-pro	meta-llama/llama-3-8b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	google/gemma-7b-it	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	google/palm-2-chat-bison-32k	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct
Motility	N/A	false	false	false	false	false	true	true	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false	false
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	true ✗	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	false	true	true	true	true	true	true	false	true	false	false	true	true	true	true	false	false	true	true	false	false	true	true	false	false	false	false
Host association	FALSE	true ✗	true ✗	true ✗	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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