Campylobacter concisus

General Information

Campylobacter concisus is a fascinating microorganism that has garnered significant interest in the scientific community due to its potential role in human health and disease. This bacterium is part of the Campylobacter genus, which is well-known for its association with gastrointestinal infections. However, C. concisus stands out due to its unique characteristics and implications in various medical conditions. One of the most intriguing aspects of C. concisus is its association with inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis. Research has suggested that this bacterium may play a role in the pathogenesis of these chronic conditions, making it a subject of intense study. The exact mechanisms by which C. concisus contributes to IBD are still under investigation, but its presence in the gut microbiota of affected individuals highlights its potential importance. Another notable feature of C. concisus is its ability to colonize the oral cavity. Unlike many other Campylobacter species that primarily inhabit the gastrointestinal tract, C. concisus can be found in the human oral microbiome. This dual habitat capability raises interesting questions about its transmission routes and ecological adaptability. From a genetic perspective, C. concisus exhibits considerable genomic diversity. This diversity is reflected in the presence of multiple strains with varying pathogenic potentials. Some strains are more virulent and have been linked to severe clinical outcomes, while others appear to be relatively benign. Understanding the genetic factors that contribute to this variability is crucial for developing targeted therapeutic strategies. In addition to its medical relevance, C. concisus is also of interest due to its unique metabolic capabilities. It can utilize a range of substrates for growth, which may contribute to its ability to thrive in different environments within the human body. This metabolic flexibility is a key area of research, as it may provide insights into how C. concisus adapts to and persists in diverse niches. Overall, Campylobacter concisus is a microorganism of significant interest due to its potential role in human disease, its unique ecological niches, and its genetic and metabolic diversity. Continued research on this bacterium is essential for unraveling its complex interactions with the human host and for developing effective interventions to mitigate its impact on health.

Campylobacter concisus is a fascinating bacterium that belongs to the genus Campylobacter, which is primarily known for its role in gastrointestinal diseases. This organism is particularly interesting due to its association with human health, especially in the context of inflammatory bowel disease (IBD) and other gastrointestinal disorders. Research has indicated that C. concisus may play a role in the pathogenesis of these conditions, making it a valuable subject for studies aimed at understanding the complex interactions between gut microbiota and host health. One of the unique characteristics of C. concisus is its ability to thrive in the human oral cavity, where it can be found in the dental plaque of individuals. This suggests a potential link between oral health and gastrointestinal diseases, highlighting the importance of oral microbiota in overall health. The organism's presence in the oral cavity raises intriguing questions about its role in oral-systemic health connections. Additionally, C. concisus has been studied for its potential to produce virulence factors that may contribute to its pathogenicity. Understanding these mechanisms could provide insights into the development of targeted therapies or preventive measures against infections caused by this bacterium. Furthermore, its relatively lesser-known status compared to other Campylobacter species makes it a unique candidate for further exploration in microbiological research. In summary, Campylobacter concisus stands out not only for its potential implications in gastrointestinal diseases but also for its intriguing relationship with oral health. Its role in the microbiome and its possible contributions to disease processes make it a significant organism for ongoing research in microbiology and health sciences.

Taxonomy

Superkingdom: Bacteria

Phylum: Campylobacterota

Class: Epsilonproteobacteria

Order: Campylobacterales

Family: Campylobacteraceae

Genus: Campylobacter

Species: Campylobacter concisus

NCBI ID

199

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCF/001/298/465/GCF_001298465.1_ASM129846v1

File for sequence-based predictions:
GCF_001298465.1_ASM129846v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The bacterium Campylobacter concisus is a member of the Campylobacter genus, which is primarily known for its role in gastrointestinal infections. While C. concisus is less commonly associated with disease compared to other Campylobacter species, it has been implicated in various clinical conditions, particularly in relation to gastrointestinal disorders. Clinical studies have suggested a potential association between C. concisus and conditions such as inflammatory bowel disease (IBD) and periodontal disease, indicating its relevance in chronic inflammatory processes. In terms of pathogenicity, C. concisus exhibits several virulence factors that may contribute to its ability to colonize and persist in the human gut. These include the production of adhesins and toxins, which can disrupt normal gut function and contribute to inflammation. Moreover, there is growing concern regarding antimicrobial resistance among Campylobacter species, including C. concisus. Resistance to commonly used antibiotics can complicate treatment options for infections, making it crucial to monitor resistance patterns in clinical isolates. Interestingly, C. concisus has also been studied for its potential role as a probiotic. Some research suggests that certain strains may have beneficial effects on gut health, although more studies are needed to fully understand its implications in human health and disease prevention. Overall, while C. concisus is not the most notorious pathogen within its genus, its associations with various diseases and potential for immune evasion strategies warrant further investigation to clarify its role in human health and disease.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Campylobacter concisus is a bacterium commonly associated with the human gastrointestinal tract, particularly in the context of gastrointestinal diseases. This microorganism thrives in the anaerobic environments of the intestines, where it plays a significant role in the complex microbial community. Its presence is often linked to conditions such as inflammatory bowel disease and periodontal disease, indicating its potential impact on human health and disease dynamics. In terms of ecological niches, C. concisus is typically found in the mucosal surfaces of the gut, where it interacts with other microbial species. This interaction can lead to symbiotic relationships or competition for resources, influencing the overall microbial balance within the gut microbiome. The bacterium's ability to adapt to the low-oxygen environments of the intestines is crucial for its survival and proliferation. Furthermore, C. concisus has been studied for its role in biofilm formation, which can enhance its persistence in the gut and contribute to its pathogenic potential. Its interactions with host immune responses also highlight its importance in the context of host-microbe interactions, making it a significant organism in understanding gut health and disease. Overall, the biomes associated with Campylobacter concisus are primarily linked to the human gut microbiome, where it occupies a niche that can have both beneficial and detrimental effects on human health.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Campylobacter concisus has garnered attention for its potential applications in various industrial sectors, particularly in biotechnology and pharmaceutical development. This organism is known for its role in the human gut microbiome, which has implications for health and disease management. Its ability to interact with the host immune system may lead to the development of novel probiotics that can enhance gut health and prevent gastrointestinal diseases. In the realm of biotechnology, Campylobacter concisus is being studied for its enzymatic activities, which could be harnessed for enzyme production that may have applications in food processing or biocatalysis. The unique metabolic pathways of this bacterium could be explored for the development of specific enzymes that facilitate various biochemical reactions. While Campylobacter concisus is primarily recognized for its pathogenic potential, its role in waste treatment processes is also being investigated. The organism's ability to degrade certain organic compounds could be utilized in biodegradation processes, contributing to waste management strategies aimed at reducing environmental pollution. Overall, while the industrial applications of Campylobacter concisus are still under research, its potential in biotechnology, waste management, and pharmaceutical development highlights the importance of understanding this microorganism's capabilities and interactions within various biomes.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 10

LLM predicted phenotypes: 3

Phenotype	High-quality annotation	google/palm-2-chat-bison-32k	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3-haiku:beta	mistralai/mistral-7b-instruct	meta-llama/llama-3-8b-instruct:nitro	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	microsoft/phi-3-mini-128k-instruct	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemma-7b-it	google/gemma-7b-it	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	google/gemini-pro	google/gemini-pro	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b
Motility	N/A	true	true	true	true	true	true	true	false	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Gram staining	gram stain negative	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	aerobic	aerotolerant ✗	N/A	aerotolerant ✗	N/A	aerotolerant ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	anaerobic ✗	anaerobic ✗	anaerobic ✗	anaerobic ✗	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	TRUE	false ✗	false ✗	false ✗	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	true ✓	true ✓	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗	false ✗
Biofilm formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Biosafety level	biosafety level 2	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 1 ✗	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓	biosafety level 2 ✓
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	N/A	gamma	N/A	gamma	N/A	N/A	N/A	N/A	N/A	beta	beta	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	spirillum	bacillus ✗	spirillum ✓	spirillum ✓	bacillus ✗	coccus ✗	spirillum ✓	bacillus ✗	coccus ✗	spirillum ✓	spirillum ✓	spirillum ✓	bacillus ✗	bacillus ✗	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	spirillum ✓	bacillus ✗	bacillus ✗	spirillum ✓	spirillum ✓

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