Streptomyces inhibens

General Information

Streptomyces inhibens is a fascinating microorganism belonging to the genus Streptomyces, which is renowned for its prolific production of secondary metabolites. One of the most intriguing aspects of S. inhibens is its ability to produce a wide array of bioactive compounds, including antibiotics, antifungals, and antitumor agents. This makes it a valuable subject of study in pharmaceutical research and biotechnology. Streptomyces species are well-known for their complex life cycle and filamentous growth, which resembles that of fungi. This characteristic allows them to thrive in diverse environments, particularly in soil, where they play a crucial role in decomposing organic matter and contributing to the nutrient cycle. The production of secondary metabolites by S. inhibens is of particular interest because these compounds have significant therapeutic potential. For instance, many antibiotics currently in use, such as streptomycin and tetracycline, were originally derived from Streptomyces species. The ability of S. inhibens to inhibit the growth of other microorganisms suggests that it could be a source of novel antimicrobial agents, which are urgently needed in the face of rising antibiotic resistance. Moreover, the genetic and metabolic pathways involved in the synthesis of these bioactive compounds are complex and highly regulated, providing a rich area for genetic and biochemical research. Understanding these pathways can lead to the development of new strategies for enhancing the production of valuable metabolites or engineering new compounds with improved efficacy and reduced side effects. In summary, Streptomyces inhibens is a microorganism of significant interest due to its remarkable capacity to produce a diverse range of bioactive compounds, its role in the environment, and its potential applications in medicine and biotechnology. Its study not only advances our understanding of microbial ecology and metabolism but also holds promise for the discovery and development of new therapeutic agents.

Streptomyces inhibens is a fascinating actinobacterium known for its remarkable ability to produce a diverse array of bioactive compounds, including antibiotics and antifungal agents. This organism is part of the larger genus Streptomyces, which is renowned for its role in natural product biosynthesis. One of the most interesting aspects of S. inhibens is its capacity to synthesize unique secondary metabolites that have potential applications in medicine and agriculture. Notably, S. inhibens has been studied for its production of the antibiotic inhibensmycin, which exhibits activity against various pathogenic bacteria. This makes it a valuable organism in the search for new antimicrobial agents, especially in the face of rising antibiotic resistance. The genetic and biochemical pathways involved in the synthesis of these compounds are of great interest to researchers, as they can provide insights into the mechanisms of natural product formation and lead to the discovery of novel drugs. Additionally, S. inhibens is known for its ability to thrive in diverse environments, which contributes to its ecological significance. It plays a crucial role in soil health and nutrient cycling, making it an important organism in agricultural research. The study of S. inhibens can also enhance our understanding of microbial interactions in soil ecosystems, particularly how it competes with other microorganisms and contributes to the overall microbial diversity. In summary, Streptomyces inhibens stands out due to its antibiotic production capabilities, ecological importance, and the potential for biotechnological applications. Its unique metabolic pathways and the compounds it produces make it a subject of ongoing research, with implications for both health and environmental sustainability.

Taxonomy

Superkingdom: Bacteria

Phylum: Actinomycetota

Class: Actinomycetes

Order: Kitasatosporales

Family: Streptomycetaceae

Genus: Streptomyces

Species: Streptomyces inhibens

NCBI ID

2293571

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/022/221/585/GCA_022221585.1_ASM2222158v1

File for sequence-based predictions:
GCA_022221585.1_ASM2222158v1_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The organism Streptomyces inhibens is a member of the genus Streptomyces, which is known for its significant role in the production of antibiotics and other bioactive compounds. This microorganism has been studied for its potential in antimicrobial resistance due to its ability to produce various secondary metabolites that can inhibit the growth of pathogenic bacteria. Its relevance in human health is primarily linked to its use in the development of novel therapeutics, particularly in the fight against multidrug-resistant infections. In addition to its therapeutic applications, Streptomyces inhibens may also play a role in probiotic formulations, contributing to gut health and potentially modulating the immune response in humans. The organism's interaction with the human microbiome is an area of ongoing research, as it may help in maintaining a balanced microbial community, which is crucial for overall health. However, the pathogenicity of Streptomyces inhibens is not well-documented, and it is not typically associated with human infections. Its primary clinical implications lie in its beneficial properties rather than disease associations. Further studies are needed to fully understand its mechanisms of action, including any immune evasion strategies it may possess, and its potential role in future medical applications such as vaccines or therapeutics.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Streptomyces inhibens is a species of actinobacteria commonly found in various terrestrial environments, particularly in soil and decaying organic matter. This microorganism thrives in nutrient-rich substrates, where it plays a crucial role in the decomposition process, contributing to nutrient cycling within the ecosystem. Its ability to produce a wide array of bioactive compounds makes it significant in the soil microbiome, where it interacts with other microorganisms and plants, often exhibiting antibiotic properties that can inhibit the growth of competing bacteria. In addition to its role in decomposition, Streptomyces inhibens is known for its symbiotic relationships with plants, where it can enhance plant growth through the production of growth-promoting substances. This interaction is particularly notable in agricultural biomes, where it can help in the biocontrol of plant pathogens, thus promoting healthier crop yields. The adaptability of Streptomyces inhibens to various environmental conditions—such as varying pH levels, moisture content, and temperature—allows it to thrive in diverse habitats, from temperate forests to arid regions. Its presence in these biomes underscores its importance in maintaining ecological balance and promoting biodiversity.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Streptomyces inhibens is known for its significant contributions to various industrial applications, particularly in the fields of biotechnology, pharmaceutical development, and agriculture. This actinobacterium is renowned for its ability to produce a wide range of bioactive compounds, including antibiotics, which are crucial in the fight against bacterial infections. The production of these compounds typically involves fermentation, where Streptomyces inhibens is cultivated under specific conditions to maximize yield. In the realm of biotechnology, Streptomyces inhibens is utilized for its enzymatic activities, particularly in the production of enzymes that can be applied in various industrial processes, such as biodegradation of complex organic materials. This capability makes it valuable in waste management, where it can help in the breakdown of pollutants and organic waste, contributing to more sustainable waste treatment solutions. Moreover, the pharmaceutical industry benefits from Streptomyces inhibens through its role in the discovery and production of novel antibiotics and other therapeutic agents. The organism's ability to synthesize secondary metabolites is harnessed in drug development, leading to the creation of new medications that can combat resistant strains of bacteria. In summary, Streptomyces inhibens plays a pivotal role in biofuel production as well, where its metabolic pathways can be exploited to convert biomass into biofuels through fermentation processes. This versatility highlights the importance of Streptomyces inhibens in advancing industrial applications across multiple sectors.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	anthropic/claude-3.5-sonnet	google/palm-2-chat-bison-32k	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	anthropic/claude-3-haiku:beta	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	google/gemini-pro	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	openai/gpt-4o	openai/gpt-4o	google/gemini-pro-1.5	google/gemini-pro-1.5	openai/gpt-4	openai/gpt-4	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	mistralai/mistral-7b-instruct
Motility	N/A	false	false	false	false	false	true	false	false	false	false	false	false	true	true	false	false	false	false	false	false	true	true	false	false	false	false	true	true
Gram staining	gram stain positive	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain positive ✓	N/A	gram stain variable ✗	N/A	gram stain positive ✓	N/A	gram stain variable ✗
Aerophilicity	aerobic	aerobic ✓	aerobic ✓	N/A	aerobic ✓	N/A	N/A	N/A	N/A	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	aerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	true ✗	false ✓	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗	true ✗
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Animal pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Biosafety level	biosafety level 1	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 3 ✗	biosafety level 3 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓	biosafety level 1 ✓
Health association	N/A	true	true	false	false	true	true	true	true	false	false	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true	false	false
Host association	FALSE	true ✗	false ✓	true ✗	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓
Hemolysis	N/A	N/A	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	tail	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗	bacillus ✗

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