Prevotella oris

General Information

Prevotella oris is a fascinating microorganism primarily due to its role in the human oral microbiome. This bacterium is part of the Prevotella genus, which is known for its diverse metabolic capabilities and its involvement in various human health conditions. One of the most interesting aspects of P. oris is its association with periodontal diseases. It is frequently found in dental plaque and has been implicated in the progression of periodontitis, an inflammatory disease affecting the tissues surrounding the teeth. P. oris is also notable for its ability to degrade complex carbohydrates, which is a common trait among Prevotella species. This metabolic versatility allows it to thrive in the nutrient-rich environment of the oral cavity. The bacterium's ability to break down glycoproteins and mucins contributes to its persistence and colonization in the mouth, making it a key player in the oral microbial community. From a research perspective, P. oris is valuable for studying the interactions between oral bacteria and the host immune system. Its role in modulating immune responses and contributing to inflammation makes it a target for understanding the mechanisms underlying oral and systemic diseases. Additionally, P. oris has been studied for its potential links to other conditions, such as cardiovascular diseases, due to the systemic effects of oral pathogens. In summary, Prevotella oris is a microorganism of significant interest due to its involvement in oral health and disease, its metabolic capabilities, and its potential impact on systemic health. Its study provides insights into the complex interactions within the oral microbiome and the broader implications for human health.

Prevotella oris is a fascinating member of the genus Prevotella, which is known for its role in the human oral microbiome. This anaerobic bacterium is primarily found in the oral cavity and is associated with various periodontal diseases. One of the most interesting aspects of Prevotella oris is its ability to metabolize a wide range of carbohydrates, which allows it to thrive in the complex environment of the mouth where nutrient availability can vary significantly. Unique Metabolic Capabilities: Prevotella oris exhibits unique metabolic pathways that enable it to utilize different substrates, including amino acids and carbohydrates, which can contribute to its survival in the competitive oral ecosystem. This metabolic versatility is particularly valuable for researchers studying microbial interactions and community dynamics in the oral microbiome. Role in Oral Health and Disease: The presence of Prevotella oris has been linked to both health and disease states in the oral cavity. Its abundance can increase in individuals with periodontal disease, making it a potential biomarker for oral health assessments. Understanding its role in disease progression can provide insights into the mechanisms of periodontal disease and inform therapeutic strategies. Research Implications: The study of Prevotella oris can shed light on the complex interactions between oral bacteria and their host, including immune responses and the impact of diet on oral health. Furthermore, its potential involvement in systemic diseases, such as cardiovascular disease and diabetes, highlights its importance in broader health contexts. In summary, Prevotella oris is a significant organism within the oral microbiome, with unique metabolic capabilities and implications for oral health and disease, making it a valuable subject for ongoing research in microbiology and health sciences.

Taxonomy

Superkingdom: Bacteria

Phylum: Bacteroidota

Class: Bacteroidia

Order: Bacteroidales

Family: Prevotellaceae

Genus: Segatella

Species: Segatella oris

NCBI ID

28135

Genome Info

FTP Path:
ftp.ncbi.nlm.nih.gov/genomes/all/GCA/900/637/655/GCA_900637655.1_52295_B01

File for sequence-based predictions:
GCA_900637655.1_52295_B01_genomic.fasta

Descriptions

Clinical Implications and Relevance

Source: gpt-4o-mini-2024-07-18

The microorganism Prevotella oris is a member of the genus Prevotella, which is known for its role in the human oral and gastrointestinal microbiota. It has been associated with various clinical implications, particularly in the context of oral health and periodontal disease. Prevotella oris is often found in the oral cavity and can contribute to the development of gingivitis and periodontitis, conditions characterized by inflammation and infection of the gums. These diseases can lead to tooth loss and have been linked to systemic conditions such as cardiovascular disease and diabetes. In addition to its role in oral diseases, Prevotella oris has been implicated in aspiration pneumonia and other respiratory infections, particularly in individuals with compromised immune systems or those who have difficulty swallowing. The organism's ability to form biofilms enhances its pathogenicity, making it more resistant to both host defenses and antimicrobial treatments. Regarding antimicrobial resistance, there is evidence that some strains of Prevotella oris exhibit resistance to commonly used antibiotics, which complicates treatment options for infections associated with this organism. This resistance is often attributed to the organism's genetic adaptability and its ability to acquire resistance genes from other bacteria. Furthermore, Prevotella oris has been studied for its potential role in probiotic therapies, as certain strains within the Prevotella genus may have beneficial effects on gut health and immune modulation. However, the clinical applications of Prevotella oris as a probiotic are still under investigation and require further research to establish efficacy and safety. Overall, Prevotella oris is significant in the context of oral health, respiratory infections, and antimicrobial resistance, highlighting the need for continued research and awareness of its clinical implications.

Habitat and Ecological Niches

Source: gpt-4o-mini-2024-07-18

Prevotella oris is a species of bacteria commonly found in the oral cavity of humans and other mammals. This microorganism thrives in the unique environment of the oral microbiome, which is characterized by a diverse community of microorganisms that coexist in a complex ecosystem. The oral cavity provides a rich source of nutrients, including carbohydrates and proteins, which are essential for the growth and metabolism of Prevotella oris. In this biome, Prevotella oris plays a critical role in the breakdown of complex carbohydrates and contributes to the overall health of the oral microbiome. It is involved in the fermentation processes that produce short-chain fatty acids, which can have beneficial effects on oral health and may help in maintaining a balanced microbial community. Additionally, Prevotella oris is known to engage in symbiotic relationships with other microorganisms in the oral cavity. It can interact with other bacteria, such as Streptococcus and Fusobacterium, facilitating a cooperative environment that enhances nutrient availability and promotes microbial diversity. This interaction is essential for preventing the overgrowth of pathogenic species that can lead to oral diseases. Furthermore, Prevotella oris exhibits remarkable environmental adaptation capabilities, allowing it to thrive in the fluctuating conditions of the oral environment, such as changes in pH, oxygen levels, and the presence of antimicrobial substances. Its ability to adapt to these conditions underscores its importance in maintaining the ecological balance within the oral microbiome and highlights its potential implications for oral health and disease.

Industrial Application

Source: gpt-4o-mini-2024-07-18

The microorganism Prevotella oris has shown potential in various industrial applications, particularly in the fields of biotechnology and waste management. This organism is part of the human oral microbiome and has been studied for its role in fermentation processes, which can be harnessed for the production of bioactive compounds. In biotechnology, Prevotella oris can be utilized in the development of probiotics, contributing to gut health and enhancing the efficacy of functional foods. Its ability to ferment carbohydrates can lead to the production of short-chain fatty acids, which are beneficial for metabolic health. In the realm of waste management, Prevotella oris has been implicated in the biodegradation of organic waste, particularly in anaerobic digestion systems. This process not only helps in reducing waste volume but also aids in the production of biogas, a renewable energy source. Furthermore, the enzymatic activities of Prevotella oris can be explored for pharmaceutical development, particularly in the synthesis of bioactive molecules that may have therapeutic properties. The organism's metabolic pathways can be investigated for the production of enzymes that are useful in various industrial processes, including enzyme production for biocatalysis. Overall, Prevotella oris presents a promising avenue for innovation in biofuel production, pharmaceuticals, and environmental sustainability, making it a valuable microorganism in modern industrial applications.

Phenotypes and Predictions

The table shows the phenotypes and predictions. Cell colors indicate the class of the value. When literature-based data is available, a checkmark (✓) indicates a correct prediction, while an ✗ indicates an incorrect prediction.

Literature-based phenotypes: 9

LLM predicted phenotypes: 4

Phenotype	High-quality annotation	openai/gpt-3.5-turbo-0125	openai/gpt-3.5-turbo-0125	google/gemini-pro-1.5	google/gemini-flash-1.5	meta-llama/llama-3-70b-instruct:nitro	google/palm-2-chat-bison-32k	perplexity/llama-3-sonar-small-32k-chat	openchat/openchat-7b	mistralai/mixtral-8x7b-instruct:nitro	mistralai/mistral-7b-instruct	openai/gpt-4o	openai/gpt-4o	anthropic/claude-3.5-sonnet	anthropic/claude-3.5-sonnet	openai/gpt-4	openai/gpt-4	anthropic/claude-3-haiku:beta	anthropic/claude-3-haiku:beta	microsoft/wizardlm-2-8x22b	microsoft/wizardlm-2-8x22b	meta-llama/llama-3-8b-instruct:nitro	meta-llama/llama-3-8b-instruct:nitro	google/gemma-7b-it	google/gemma-7b-it	microsoft/phi-3-mini-128k-instruct	microsoft/phi-3-mini-128k-instruct	google/gemini-pro	google/gemini-pro
Motility	N/A	true	true	false	false	false	true	true	false	true	true	false	false	false	false	false	false	false	false	false	false	true	true	true	true	false	false	true	true
Gram staining	gram stain negative	N/A	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓	N/A	gram stain negative ✓
Aerophilicity	anaerobic	facultatively anaerobic ✗	facultatively anaerobic ✗	anaerobic ✓	N/A	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	anaerobic ✓	N/A	N/A	anaerobic ✓	anaerobic ✓	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Extreme environment tolerance	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	true ✗	true ✗	false ✓	false ✓	false ✓	false ✓
Biofilm formation	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	false	false	true	true
Animal pathogenicity	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓
Biosafety level	biosafety level 1	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗	biosafety level 2 ✗
Health association	N/A	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true	true
Host association	TRUE	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	true ✓	false ✗	false ✗	true ✓	true ✓	true ✓	true ✓
Plant pathogenicity	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Spore formation	FALSE	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓	false ✓
Hemolysis	N/A	beta	beta	N/A	gamma	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	alpha	alpha	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cell shape	bacillus	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓	bacillus ✓	bacillus ✓	coccus ✗	coccus ✗	bacillus ✓	bacillus ✓

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